Diseases of the oral mucous membranes

Camisa, Charles; Rindler, Joan M.

doi:10.1016/s1040-0486(05)80005-5

Cited by 7 publications

(5 citation statements)

References 363 publications

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“…The 14.2% (3/21) of patients with exclusively oral lesion found in our study is comparable to 16.5% from Iran [ 80 ], but in contrast to 86% found in Northern Greece [ 44 ]. Exclusively oral lesions tend to be a marker for less virulent disease and a better prognosis [ 81 ]. It is uncommon to clinically identify vesicles or bullae in the oral mucosa due to continuous mechanical forces that characterize the normal activity of the mouth.…”

Section: Discussionmentioning

confidence: 99%

Clinical and histological characterization of oral pemphigus lesions in patients with skin diseases: a cross sectional study from Sudan

et al. 2013

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BackgroundPemphigus is a rare group of life-threatening mucocutaneous autoimmune blistering diseases. Frequently, oral lesions precede the cutaneous ones. This study aimed to describe clinical and histological features of oral pemphigus lesions in patients with skin disease has been canceled aged 18 years and above, attending outpatient’s facility of Khartoum Teaching Hospital - Dermatology Clinic, Sudan. In addition, the study aimed to assess the diagnostic significance of routine histolopathology along with immunohistochemical (IHC) examination of formalin-fixed, paraffin-embedded biopsy specimens in patients with oral pemphigus.MethodsA cross-sectional hospital-based study was conducted from October 2008 to January 2009. A total of 588 patients with confirmed skin has been canceled disease diagnosis completed an oral examination and a personal interview. Clinical evaluations supported with histopathology were the methods of diagnosis. IHC was used to confirm the diagnosis. Location, size, and pain of oral lesions were used to measure the oral disease activity.ResultsTwenty-one patients were diagnosed with pemphigus vulgaris (PV), 19 of them (mean age: 43.0; range: 20–72 yrs) presented with oral manifestations. Pemphigus foliaceus was diagnosed in one patient. In PV, female: male ratio was 1.1:1.0. Buccal mucosa was the most commonly affected site. Exclusive oral lesions were detected in 14.2% (3/21). In patients who experienced both skin and oral lesion during their life time, 50.0% (9/18) had oral mucosa as the initial site of involvement, 33.3% (6/18) had skin as the primary site, and simultaneous involvement of both skin and oral mucosa was reported by 5.5% (1/18). Two patients did not provide information regarding the initial site of involvement. Oral lesion activity score was higher in those who reported to live outside Khartoum state, were outdoor workers, had lower education and belonged to Central and Western tribes compared with their counterparts. Histologically, all tissues except one had suprabasal cleft and acantholytic cells. IHC revealed IgG and C3 intercellularly in the epithelium.ConclusionsPV was the predominating subtype of pemphigus in this study. The majority of patients with PV presented with oral lesions. Clinical and histological pictures of oral PV are in good agreement with the literature. IHC confirmed all diagnoses of PV.

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Section: Discussionmentioning

confidence: 99%

Clinical and histological characterization of oral pemphigus lesions in patients with skin diseases: a cross sectional study from Sudan

et al. 2013

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“…Intralesional injections of triamcinolone (10 mg/cc) may be quite beneficial for slow‐healing, atrophic–erosive OLP (47, 48). However, the injections can be extremely effective in inducing the healing of lesions, but they have a very localized effect such as mucosal atrophy (1, 49).…”

Section: Discussionmentioning

confidence: 99%

Clinical evaluation in treatment of oral lichen planus with topical fluocinolone acetonide: a 2‐year follow‐up

Thongprasom

Luengvisut

Wongwatanakij

et al. 2003

J Oral Pathology Medicine

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“…However, candidiasis can be controlled or prevented by using anti-fungal therapy (eg, miconazole gel alone or in combination with nystatin suspension) in topical corticosteroids (15,29,31,46). Even though the intralesional injection of corticosteroids can induce the healing of the longstanding lesions and improve the symptoms, it can have a localized side-effect such as mucosal atrophy (1,53). However, the side-effects can be due to the absorption of topical steroid from oral mucosa mainly by direct absorption or by ingestion following incorrect use of the preparations.…”

Section: Side-effects Of Steroidsmentioning

confidence: 99%

Steriods in the treatment of lichen planus: a review

2008

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Steroids have been found to be effective in treating symptomatic oral lichen planus (OLP) by reducing pain and inflammation. In fact, systemic corticosteroids should be reserved for acute exacerbation, and multiple or widespread lesions. They may be indicated in patients whose condition is unresponsive to topical steroids. However, various potent topical steroids have been reported to be effective in the treatment of symptomatic OLP. They can be used as the first line drugs in the treatment of OLP with no serious side-effects. During the therapy, candidiasis was commonly found and in addition, bad taste, nausea, dry mouth, sore throat and swollen mouth may occur as minor side-effects from some topical steroids. Because OLP is a chronic disorder that requires long-term treatment, topical steroids are recommended for the treatment OLP because of minimal side-effects and the cost benefit. This manuscript reviews the use of steroids, especially its topical application, in the treatment of

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Diseases of the oral mucous membranes

Cited by 7 publications

References 363 publications

Clinical and histological characterization of oral pemphigus lesions in patients with skin diseases: a cross sectional study from Sudan

Clinical and histological characterization of oral pemphigus lesions in patients with skin diseases: a cross sectional study from Sudan

Clinical evaluation in treatment of oral lichen planus with topical fluocinolone acetonide: a 2‐year follow‐up

Steriods in the treatment of lichen planus: a review

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