QUITE recently two genuine cases of lipodystrophia progressiva in males have been published. J. Gerstmann's case [33] is that of a soldier, aged 32 years, who at the age of 10 years commenced to show symmetrical wasting of the subcutaneous fat in the face. Since then the fat-atrophy has gradually spread over the neck, upper extremities, and trunk, as far as the pelvic bones (the inguinal folds and the iliac crests). There is excessive amount of subcutaneous fat in the buttocks and lower extremities. The muscular development in the lean parts is very good. The man presents likewise signs suggestive of thyroidal disturbance, " facial irritability," alimentary glycosuria, and some nervous symptoms, which may, however, not be in any way related to the lipodystrophia. H. Gerhartz's case [34] is that of a man, aged 29 years, whose " lipodystrophia progressiva superior," as Gerhartz prefers to call it, commenced at the age of 6 years, after an accident on the ice in which the patient nearly lost his life. In this case, however, there is no excessive accumulation of subcutaneous fat in the buttocks and lower extremities. The patient shows various other abnormalities (" facial irritability," hyperidrosis, alimentary glycosuria, &c.), the connexion of which with the fat-atrophy is by no means clear. Lipodystrophia progressiva is a rare disease or morbid condition, which was at first supposed to be confined to the female sex. It is characterized by the progressive disappearance of the subcutaneous fat from the face and upper parts of the body. The term " lipodystrophia progressiva" was introduced by A. Simons (1911), and the appearance in his case as portrayed in his and E. Holliinder's illustrations (1910) may be accepted as altogether typical for the disease [1]. Though Simnons.was undoubtedly the first to use the term lipodystrophia (from the Greek words Xt'7ro, Sv9-, and 'pocr', signifying respectively fat, badly, and nourishment), a characteristic example of the disease was In this paper the reference numbers in brackets are to the Literature references at the end.