Disease‐Specific Survival with Spindle Cell Carcinoma of the Head and Neck

Bice, Tristan; Tran, Van Du T.; Merkley, Mark A.; Newlands, Shawn D.; Sloot, Paul G. van der; Wu, Shuang; Miller, Matthew C.

doi:10.1177/0194599815594360

Cited by 36 publications

(37 citation statements)

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“…This conclusion, however, may be confounded by the fact that TL is more often performed to remove larger malignant tumors, which carry higher risk. The associations found for other clinical features were consistent with the findings of previous studies, as low tumor differentiation, and higher T, N, and clinical stages all correlated with worse prognoses [15, 16]. …”

Section: Discussionsupporting

confidence: 90%

Association of genetic polymorphisms with laryngeal carcinoma prognosis in a Chinese population

et al. 2016

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We analyzed the effects of single-nucleotide polymorphisms (SNPs) on laryngeal carcinoma (LC) risk and overall survival (OS) in 170 Chinese male LC patients followed for 10 years. After assessment of clinical characteristics (age, laryngectomy, neck dissection, tumor differentiation, TNM status), the patients were genotyped for 24 SNPs associated with risk in multiple cancers. LC risk was assessed using log-rank test and Cox proportional hazard models. The median OS time was 48 months. By the follow-up deadline, OS was 41.2%. Kaplan-Meier analysis indicated 1-, 3-, and 5-year survival rates to be 84.7%, 57.2%, and 47.1%, respectively. Five LC clinicopathological characteristics, namely total laryngectomy (TL), low differentiation (LD), T3-T4, N1-N2, and clinical stage III-IV were associated with worse OS (HR: 2.35, p < 0.001; HR: 2.39, p = 0.02; HR: 2.17, p < 0.001; HR: 2.39, p < 0.001; and HR: 3.29, p < 0.001, respectively). Univariate cox regression analysis indicated that four SNPs were associated (p < 0.05) with LC OS in the codominant genetic model compared to patients with the homozygous wild-type genotype: rs10088262 G/A (HR = 1.57), rs1665650 A/G (HR = 0.65); rs3802842 C/C (HR = 2.18), and rs59336 T/A and T/T (HR = 0.61 and 2.61, respectively).

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Section: Discussionsupporting

confidence: 90%

Association of genetic polymorphisms with laryngeal carcinoma prognosis in a Chinese population

et al. 2016

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“…It has been widely investigated and recognized that SpCC has worse prognosis than SCC [15]. Intrinsic tumor properties and lack of standard treatment guidelines may be the possible explanations for the unfavorable prognosis.…”

Section: Discussionmentioning

confidence: 99%

Spindle cell carcinoma: the general demographics, basic clinico-pathologic characteristics, treatment, outcome and prognostic factors

et al. 2017

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BackgroundOwing to the rarity, the general demographics, basic clinico-pathologic features, management, outcome and prognostic factors of spindle cell carcinoma (SpCC) were unexplored.MethodsA SEER analysis was performed with 2336 cases (1973-2016).ResultsA peak incidence occurred at 70~80 years without any gender predominance and 83.13% occurred in white people. The respiratory system was mostly affected tumor site (35%). Significant overall survival (OS) and disease specific survival (DSS) were found differentiated in gender, age, marital status, primary tumor location, AJCC stage, T stage, N stage, M stage, pathologic grade and treatment modality. In the multivariate Cox model, the age > 69 years (Hazard ratio [HR] = 1.427 for OS, P = 0.01 and HR = 1.491 for DSS, P = 0.003; Reference [Ref] age ≤ 69 years), tumor location in respiratory system (HR = 1.550 for OS, P = 0.041 and HR = 1.561 for DSS, P = 0.04; Ref: digestive system), N2 stage (HR = 1.962 for OS, P = 0.006 and HR = 1.982 for DSS, P = 0.004; Ref: N0 stage) and AJCC stage IV (HR = 4.601 for OS, P = 0.000 and HR = 5.107 for DSS, P = 0.000; Ref: stage I) were independently associated with worse OS and DSS.ConclusionsSpCC mostly occurred in white people at 70~80 years old without predominance in any gender. The respiratory system was mostly affected site. The patient's age, primary tumor location, AJCC stage were independent prognostic indicators for both DSS and OS of SpCC.

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“…At the same time, there was no difference in the outcome for larynx or hypopharynx site. In his large study analysing 118 patients he identified in multivariate analysis only age, tumour size, and M (metastatic) stage as variables significantly affecting the survival with SpCC [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Spindle cell carcinoma of the head and neck region: treatment and outcomes of 15 patients

Iqbal

Paleri

Brown

et al. 2015

ecancer

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IntroductionSpindle cell carcinoma of the head and neck is a rare entity and the evidence of optimal management is lacking. The objective of our study was to report the treatment and outcomes of 15 patients treated in a single institution over a seven year period.Materials and MethodsA total of 15 patients (12 males and 3 females) with spindle cell carcinoma of the head and neck were treated between July 2007 to June 2014. In six patients the disease developed after previous radiotherapy. Of the 15 patients, five patients had their primary in the tongue, four in the paranasal sinuses, two in the hypopharynx, two in the vocal cords, and one each in the soft palate and the floor of mouth. Eleven patients were treated with radical intent (seven patients required surgery only and four were treated with combined modality). The remaining four patients were treated with palliative intent.ResultsAmong 11 patients treated with radical intent eight are alive or died of non-oncological causes. The disease recurred locally in three patients and they died of the disease (two patients with locally advanced disease in the tongue and one patient with T1N0 tumour in the hypopharynx). Median overall survival (OS) was 18 months.ConclusionSurgery or surgery combined with radiotherapy has a real impact on the natural cause of spindle cell carcinoma of the head and neck region. Even locally advanced tumours can be controlled with aggressive treatment. The worst outcome is seen with the tongue as the primary site because of a high local recurrence rate.

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Disease‐Specific Survival with Spindle Cell Carcinoma of the Head and Neck

Abstract: Spindle cell carcinoma carries a worse prognosis than SCC. Larger tumor size, older age, and metastatic disease portend worse survival with SpCC of the head and neck.

Cited by 36 publications

References 36 publications

Association of genetic polymorphisms with laryngeal carcinoma prognosis in a Chinese population

Association of genetic polymorphisms with laryngeal carcinoma prognosis in a Chinese population

Spindle cell carcinoma: the general demographics, basic clinico-pathologic characteristics, treatment, outcome and prognostic factors

Spindle cell carcinoma of the head and neck region: treatment and outcomes of 15 patients

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