Disease‐specific health‐related quality of life (HRQL) instruments for food allergy: protocol for a systematic review

Salvilla, Sarah A; Panesar, Sukhmeet S.; Patel, Shyamal; Rader, Tamara; Muraro, Antonella; Roberts, Graham; de-Blok, Bertine Flokstra; Dubois, Anthony; Sheikh, Aziz

doi:10.1186/2045-7022-3-15

Cited by 6 publications

(8 citation statements)

References 15 publications

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“…crd.york.ac.uk/prospero/) and has the reference number CRD42013003710. Detailed information on our methods, including the search strategy, study selection, quality assessment strategy, analysis, data synthesis, and reporting, has been reported in advance in our published protocol (11). We provide a brief synopsis of our methods below.…”

Section: Registration and Protocolmentioning

confidence: 99%

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Disease‐specific health‐related quality of life instruments for IgE‐mediated food allergy

Salvilla

Dubois

Blok

et al. 2014

Allergy

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This is one of seven interlinked systematic reviews undertaken on behalf of the European Academy of Allergy and Clinical Immunology as part of their Guidelines for Food Allergy and Anaphylaxis, which focuses on instruments developed for IgE-mediated food allergy. Disease-specific questionnaires are significantly more sensitive than generic ones in measuring the response to interventions or future treatments, as well as estimating the general burden of food allergy. The aim of this systematic review was therefore to identify which disease-specific, validated instruments can be employed to enable assessment of the impact of, and investigations and interventions for, IgE-mediated food allergy on health-related quality of life (HRQL). Using a sensitive search strategy, we searched seven electronic bibliographic databases to identify disease-specific quality of life (QOL) tools relating to IgE-mediated food allergy. From the 17 eligible studies, we identified seven disease-specific HRQL instruments, which were then subjected to detailed quality appraisal. This revealed that these instruments have undergone formal development and validation processes, and have robust psychometric properties, and therefore provide a robust means of establishing the impact of food allergy on QOL. Suitable instruments are now available for use in children, adolescents, parents/caregivers, and adults. Further work must continue to develop a clinical minimal important difference for food allergy and for making these instruments available in a wider range of European languages.The term 'food allergy' refers to the subgroup of foodtriggered reactions in which immunologic mechanisms have been implicated, whether immunoglobulin E (IgE)-mediated, non-IgE-mediated, or involving a combination of IgE-and non-IgE-mediated etiologies (1). This review focuses on food allergy that is likely to have an IgE-mediated etiology.Allergy 69 (2014) 834-844

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Section: Registration and Protocolmentioning

confidence: 99%

“…The main strengths of this work include the use of formal systematic review methods, including the development of a formal systematic review protocol, which was published in advance (11), and the involvement of a multidisciplinary group of experts from a range of European countries.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Disease‐specific health‐related quality of life instruments for IgE‐mediated food allergy

Salvilla

Dubois

Blok

et al. 2014

Allergy

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“…Although with adequate avoidance strategies, allergic reactions are infrequent, food allergy can result in considerable anxiety mainly due to their unpredictability. 8 Therefore, food allergy represents a considerable burden to individuals, families and society.…”

Section: Introductionmentioning

confidence: 99%

“…15 In practice, this is rarely achieved in many countries in the developed world. 8 Where breastfeeding is not prolonged, delaying the introduction of complementary foods means that there is less or even no overlap between breastfeeding and the introduction of solids and this may have a detrimental effect on allergy development. 11 Additionally, guidelines may be directed at particular population groups (eg high-risk infants) but are followed by all population groups.…”

Section: P Otential Impac T Of Altering the Ag E Of Introduction mentioning

confidence: 99%

Can dietary strategies in early life prevent childhood food allergy? A report from two iFAAM workshops

Roberts

Grimshaw

Beyer

et al. 2019

Clin Experimental Allergy

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Food allergy affects a small but significant number of children and adults. Food allergy is responsible for considerable morbidity and is the commonest cause of anaphylaxis in children. One of the aims of the European Union‐funded “Integrated Approaches to Food Allergen and Allergy Risk Management” (iFAAM) project was to improve our understanding of the best way to prevent the development of food allergy. Groups within the project worked on integrating the current prevention evidence base as well as generating new data to move our understanding forward. This paper from the iFAAM project is a unique addition to the literature on this topic as it not only outlines the recently published randomized controlled trials (as have previous reviews) but also summarizes two iFAAM‐associated project workshops. These workshops focused on how we may be able to use dietary strategies in early life to prevent the development of food allergy and summarized the range of opinions amongst experts in this controversial area.

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“…Many of these studies have employed questionnaires designed to illuminate some aspect of the experience of patients with food allergy using both qualitative and quantitative approaches. This guideline focuses on instruments designed to measure HRQL in a quantitative and disease-specific fashion and, in particular, draws upon a systematic review of existing instruments, one of seven interlinked evidence syntheses undertaken to provide a state-of-the-art synopsis of the current evidence base in this area (10). That review included a comprehensive search and quality assessment of instruments with special attention to the method of validation used.…”

Section: Scope and Purpose Of The Guidelinementioning

confidence: 99%

EAACI Food Allergy and Anaphylaxis Guidelines. Food allergy health‐related quality of life measures

Muraro

Dubois

DunnGalvin

et al. 2014

Allergy

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Instruments have been developed and validated for the measurement of healthrelated quality of life in patients with food allergy. This guideline has been prepared by the European Academy of Allergy and Clinical Immunology's (EAACI) Guidelines for Food Allergy and Anaphylaxis Group. It draws on a systematic review of the literature on quality of life instruments for food allergy and the Appraisal of Guidelines for Research & Evaluation (AGREE II) guideline development process. Guidance is provided on the use of such instruments in research, and the current limitations of their use in clinical practice are described. Gaps in current knowledge as well as areas of future interest are also discussed. This document is relevant to healthcare workers dealing with food-allergic patients, scientists engaging in food allergy research and policy makers involved in regulatory aspects concerning food allergy and safety.In recent decades, food allergy has emerged as a significant medical problem throughout Europe (1). As the medical morbidity and mortality associated with food allergy is limited to symptoms resulting from incidental ingestions of allergenic foods, conventional, symptom-based outcome measures fail to reflect the ongoing burden of this condition to patients' well-being. Although health-related quality of life (HRQL) (Box 1) is an important outcome measure for many diseases, it is of particular importance for food allergy because there are no alternatives of sufficient sensitivity for use in most clinical situations. The relevance of HRQL measurement in allergy research, clinical practice and regulatory processes has been emphasized previously (2).Allergy 69 (2014) 845-853

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Disease‐specific health‐related quality of life (HRQL) instruments for food allergy: protocol for a systematic review

Cited by 6 publications

References 15 publications

Disease‐specific health‐related quality of life instruments for IgE‐mediated food allergy

Disease‐specific health‐related quality of life instruments for IgE‐mediated food allergy

Can dietary strategies in early life prevent childhood food allergy? A report from two iFAAM workshops

EAACI Food Allergy and Anaphylaxis Guidelines. Food allergy health‐related quality of life measures

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