Disease‐Specific Cerebrospinal Fluid Investigations

Deisenhammer, Florian; Egg, R.; Giovannoni, Gavin; Hemmer, Bernhard; Petzold, Axel; Sellebjerg, Finn; Teunissen, C.E.; Tumani, Hayrettin

doi:10.1002/9781444346268.ch13

Cited by 2 publications

(3 citation statements)

References 236 publications

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“…Sampling CSF requires a needle to be advanced into the subarachnoid space (SAS) under aseptic conditions. In humans, the technique performed most frequently is a lumbar puncture, whereas in small animal medicine, the sample can be taken from the cerebellomedullary cistern (CMC) or via a lumbar puncture 4,5 . The placement of this needle is inherently invasive, so CSF sampling is subject to procedural complications.…”

Section: Introductionmentioning

confidence: 99%

“…In humans, the technique performed most frequently is a lumbar puncture, whereas in small animal medicine, the sample can be taken from the cerebellomedullary cistern (CMC) or via a lumbar puncture. 4,5 The placement of this needle is inherently invasive, so CSF sampling is subject to procedural complications. In humans, frequently reported complications following lumbar puncture include a headache and back pain, occurring in up to 40% and 17% of patients, respectively.…”

Section: Introductionmentioning

confidence: 99%

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Complications associated with cerebrospinal fluid collection in dogs

et al. 2023

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BackgroundThis study aimed to identify complications associated with cerebrospinal fluid (CSF) collection in dogs.MethodsThis was a prospective, observational multicentre study using data collected from 102 dogs undergoing CSF collection for the investigation of neurological disease. CSF was collected from the cerebellomedullary cistern (CMC), lumbar subarachnoid space (LSAS) or both sites. Pre‐, intra‐ and postprocedural data were collected. Descriptive statistics were performed to outline complications associated with CSF collection.ResultsCSF sampling was attempted on 108 occasions, and CSF was acquired on 100 occasions (92.6%). Collection from the CMC was more likely to be successful than that from the LSAS. No dogs exhibited neurologic deterioration following CSF collection. There was no significant difference between pre‐ and post‐CSF collection short‐form Glasgow composite measure pain scores in ambulatory dogs (p = 0.13).LimitationsThe scarcity of complications limited the ability to quantify the incidence of some potential complications reported elsewhere.ConclusionsOur results may be used to inform clinicians and owners that CSF sampling is associated with a low frequency of complications when performed by trained personnel.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Complications associated with cerebrospinal fluid collection in dogs

et al. 2023

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“…Although these fluids are easier to collect, they reflect systemic rather than cerebral changes 10 . Cerebrospinal fluid (CSF) could better reflect brain neurochemistry, 11,12 but its sampling is hampered by logistical and ethical issues.…”

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confidence: 99%

Cerebrospinal Fluid and Plasma Amine Profiles in Interictal Migraine

Onderwater

Dongen

Harms

et al. 2023

Annals of Neurology

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Objective Impaired amine metabolism has been associated with the etiology of migraine, that is, why patients continue to get migraine attacks. However, evidence from cerebrospinal fluid (CSF) is lacking. Here, we evaluated individual amine levels, global amine profiles, and amine pathways in CSF and plasma of interictal migraine patients and healthy controls. Methods CSF and plasma were sampled between 8:30 am and 1:00 pm, randomly and interchangeably over the time span to avoid any diurnal and seasonal influences, from healthy volunteers and interictal migraine patients, matched for age, sex, and sampling time. The study was approved by the local medical ethics committee. Individual amines (n = 31), global amine profiles, and specific amine pathways were analyzed using a validated ultraperformance liquid chromatography mass spectrometry platform. Results We analyzed n = 99 participants with migraine with aura, n = 98 with migraine without aura, and n = 96 healthy volunteers. Univariate analysis with Bonferroni correction indicated that CSF L‐arginine was reduced in migraine with aura (10.4%, p < 0.001) and without aura (5.0%, p = 0.03). False discovery rate‐corrected CSF L‐phenylalanine was also lower in migraine with aura (6.9%, p = 0.011) and without aura (8.1%, p = 0.001), p = 0.088 after Bonferroni correction. Multivariate analysis revealed that CSF global amine profiles were similar for both types of migraine (p = 0.64), but distinct from controls (p = 0.009). Global profile analyses were similar in plasma. The strongest associated pathways with migraine were related to L‐arginine metabolism. Interpretation L‐Arginine was decreased in the CSF (but not in plasma) of interictal patients with migraine with or without aura, and associated pathways were altered. This suggests that dysfunction of nitric oxide signaling is involved in susceptibility to getting migraine attacks. ANN NEUROL 2023;93:715–728

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Disease‐Specific Cerebrospinal Fluid Investigations

Cited by 2 publications

References 236 publications

Complications associated with cerebrospinal fluid collection in dogs

Complications associated with cerebrospinal fluid collection in dogs

Cerebrospinal Fluid and Plasma Amine Profiles in Interictal Migraine

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