Disease Severity and Quality of Life in Patients With Idiopathic Pulmonary Fibrosis

investigators, Ipf-Pro Registry

doi:10.1016/j.chest.2019.11.042

Cited by 24 publications

(6 citation statements)

References 33 publications

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“…Overall, our study population has better HRQL scores than existing local or overseas cohorts ( 14 , 24 ). The most likely explanation is the milder disease severity in our patient population, as evidenced by the higher FVC and DLCO %pred values compared with other studies, with almost two-thirds of our patients being GAP Stage I ( 25 ). Consistent with other studies, IPF patients have the poorest HRQL scores in terms of EQ5D-3L utility value, K-BILD total, ‘psychological’, ‘breathlessness and activities domain’ compared to CTD-ILD and other ILD patients ( 26 , 27 ).…”

Section: Discussionmentioning

confidence: 42%

“…Our study showed that the DLCO %pred, but not FVC %pred, is a significant predictor of poor K-BILD total, ‘psychological’ and ‘breathlessness and activities’ domains in ILD patients. Indeed, a lower baseline DLCO %pred is associated not only with poorer HRQL ( 25 , 34 ) but also with future HRQL deterioration ( 16 , 41 ). Even though the degree of reduction in DLCO usually mirrors the corresponding drop in FVC, a severe reduction in DLCO may represent the presence of pulmonary hypertension on top of lung parenchymal destruction from ILD, and pulmonary hypertension has been shown to decrease the quality of life in IPF patients ( 42 ).…”

Section: Discussionmentioning

confidence: 99%

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Health-related quality of life in a multiracial Asian interstitial lung disease cohort

Phua¹,

Tan²,

Phua³

et al. 2022

J Thorac Dis

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Background: Understanding health-related quality of life (HRQL) in patients with interstitial lung disease (ILD) provides insight into disease burden and treatment effects on patients' well-being. We examined HRQL in a multiracial Asian ILD cohort using the King's brief ILD (K-BILD) and EuroQol 5-dimension-3-level (EQ5D-3L) questionnaires and their associations with several clinical variables.Methods: This was a single-centre cross-sectional study of ILD patients in a university-affiliated tertiary public hospital in Singapore. All patients completed two self-administered HRQL questionnaires upon study entry, and their clinical information was retrieved from electronic medical records.Results: Ninety-nine patients (56% male, 75% Chinese) were included. The median (interquartile range) age was 63 (54-72) years. The most common ILD diagnosis was connective tissue disease-related ILD (n=51, 52%), followed by idiopathic pulmonary fibrosis (n=27, 27%). The mean (standard deviation) scores for the EQ5D-3L utility value, EQ5D Visual Analogue Scale (VAS) and K-BILD total were 0.806 (0.284), 75.1 (12.8) and 63.9 (14.3), respectively. A moderate correlation was found between the EQ5D-3L and K-BILD total and domain scores. The HRQL scores also correlate moderately with the modified Medical Research Council dyspnoea scale (mMRC) scores. There was a weak-to-moderate correlation between HRQL and FVC, DLCO and Charlson comorbidity index. Multiple linear regression showed a significant association of K-BILD total (beta coefficient 0.244, 95% CI: 0.075-0.414; P=0.005), K-BILD 'breathlessness and activities' (beta coefficient 0.448, 95% CI: 0.192-0.703; P=0.001), and the 'psychological' domain (beta coefficient 0.256, 95% CI: 0.024-0.488; P=0.031) with DLCO %pred after adjustment for age, sex, BMI, race, smoking history, comorbidities, FVC %pred and ILD diagnosis. Non-Chinese race was a predictor of better K-BILD

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Section: Discussionmentioning

confidence: 42%

Section: Discussionmentioning

confidence: 99%

Health-related quality of life in a multiracial Asian interstitial lung disease cohort

Phua¹,

Tan²,

Phua³

et al. 2022

J Thorac Dis

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“…Research suggests that measuring frailty might give insight into the physical constitution of patients suffering from lung diseases (40). We chose supplemental oxygen use at rest since this is a parameter that most patients are well aware of and it is one objective marker for disease severity used also in other studies (41,42). Additionally, patients included in this study were recruited during psychosocial evaluation before listing for transplantation.…”

Section: Discussionmentioning

confidence: 99%

Factor Analyses and Validity of the Transplant Evaluation Rating Scale (TERS) in a Large Sample of Lung Transplant Candidates

et al. 2020

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Objective: It is well known that the occurrence of mental disorders is more common in lung transplant candidates compared to the general population. After transplantation mental disorders may negatively affect quality of life, adherence to immunosuppressive medication, as well as overall survival. Therefore, the identification of patients at risk is of utmost importance and in Germany pre-transplant psychosocial evaluation of the patients is required. To ensure high quality and comparability of these assessments, the use of psychometrically sound instruments is recommended. We applied the Transplant Evaluation Rating Scale (TERS), a broadly used expert interview. Two research groups have detected a two-factor structure of the TERS in different transplant samples; however, with slightly different results. The present study investigated which of the models would fit best in our sample of lung transplant patients. Additionally, we assessed convergent and predictive validity of the best fitting model to evaluate its clinical usefulness.Methods: Between 2016 and 2019, 390 lung transplant candidates were evaluated and included in the study. The median age was 53 years and 54% were male. TERS interviews were conducted by trained medical doctors and psychologists. The participants completed questionnaires assessing quality of life and levels of depression and anxiety. Transplant-and disease-specific variables (lung disease, listing date, oxygen use) were taken from the patient charts. Confirmatory factor analysis was used to test the two proposed TERS-models in the present sample. Results:The two-factor structure of the TERS reported by Hoodin and Kalbfleisch fit our sample best, showing good psychometric properties. The factor "emotional sensitivity" was highly correlated with quality of life and measures of psychosocial health while the factor "defiance" correlated with obstructive lung disease and older age but not with

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“…The MCID on the SGRQ was defined as a mean four-point change in total score, as proposed by Jones PW et al [ 16 ] The SGRQ has been validated and commonly used in patients with IPF. [ 17 ]…”

Section: Methodsmentioning

confidence: 99%

The clinical efficacy of a mixture of ivy leaf extract and coptidis rhizome in patients with idiopathic pulmonary fibrosis

et al. 2023

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Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with poor prognosis and cough is the one of most common and major symptoms in IPF. The aim of this study was to evaluate the clinical efficacy of a Mixture of Ivy Leaf Extract and Coptidis rhizome (Synatura®) in patients with IPF. This was a prospective, open-label, single-center, and single-arm study in Korea from October 2019 to September 2020. IPF patients with chronic bronchitis were enrolled. Between baseline and eight weeks after use of Synatura®, clinical measures regarding cough and health-related quality of life, and the systemic inflammatory markers was prospectively collected. Thirty patients were enrolled. Median age was 73 years and 86.7% were men. The median gender-age-pulmonary function stage of IPF was 3. Baseline total score of Leicester cough questionnaire (LCQ) and St. George respiratory questionnaire (SGRQ) were 104.5 and 30.59 respectively. After eight weeks, there was no significant improvement in LCQ (16.8 [15.6–19.1] vs 17.5 [15.2–18.9], P = .772) and SGRQ (30.6 [19.4–37.8] vs 29.9 [19.6–41.8], P = .194) scores. Also, there was no significant difference of systemic inflammatory markers. In analysis of minimal clinically important differences (MCID), one third (33.3%) patients fulfilled the criteria of MCID (1.3) in LCQ scores and median differences was 14 (range: 10–18). In terms of SGRQ, 6 patients (20%) reached MCID (4.0) without significant predictive factors. In our study, use of Synatura® during 8 weeks improved cough-specific life quality in one third patients with IPF. Large-scale, randomized, double-blind, and placebo-controlled clinical trials are needed.

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Disease Severity and Quality of Life in Patients With Idiopathic Pulmonary Fibrosis

Cited by 24 publications

References 33 publications

Health-related quality of life in a multiracial Asian interstitial lung disease cohort

Health-related quality of life in a multiracial Asian interstitial lung disease cohort

Factor Analyses and Validity of the Transplant Evaluation Rating Scale (TERS) in a Large Sample of Lung Transplant Candidates

The clinical efficacy of a mixture of ivy leaf extract and coptidis rhizome in patients with idiopathic pulmonary fibrosis

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