Disease progression and comorbidities in lipedema patients: A 10‐year retrospective analysis

Ghods, Mojtaba; Georgiou, Iakovos; Schmidt, Jeremias; Kruppa, Philipp

doi:10.1111/dth.14534

Cited by 23 publications

(51 citation statements)

References 38 publications

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“…The skin appears fresh, pale blue, soft, and treatable; Stemmer's sign is negative [7][8][9][10]. Several types and stages are used to characterize lipedema [7,8], and in this enigmatic disease of the peripheral adipose tissue [10,11], patients display several comorbidities, including migraine [12]. The common thread of nonsurgical management of lipedema should be to limit possible inflammatory states.…”

Section: Introductionmentioning

confidence: 99%

Management of Lipedema with Ketogenic Diet: 22-Month Follow-Up

Cannataro

Michelini

Ricolfi

et al. 2021

Life

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Lipedema is a pathology of adipose tissue, still of unclear etiology and challenging to diagnose. For these reasons, a therapeutic approach is also complex and sometimes controversial. The inflammation state present in lipedema can be limited by controlling the glycemic peaks. Specifically, the ketogenic diet (KD) seems to have the right conditions to be effective. Herein, we reported a subject diagnosed with lipedema who, with only KD nutritional intervention, achieved a significant weight loss (−41 Kg), with a net decrease in body circumferences, and also reporting an improvement in pain, and therefore in the overall quality of life. She refused other types of intervention and kept KD for two years. This case could represent the first step to organize a KD nutritional protocol specifically applied to lipedema.

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Section: Introductionmentioning

confidence: 99%

Management of Lipedema with Ketogenic Diet: 22-Month Follow-Up

Cannataro

Michelini

Ricolfi

et al. 2021

Life

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“…There was a relatively large difference in the prevalence of hypothyroidism in patients with lipoedema (27.5%) compared to the prevalence of this disease among the general population (0.5–2%). The relationship between the above diseases is not fully explained, but it can be assumed that hormonal disorders have a significant influence on lipoedema [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…The research was conducted using PRISMA methodotogy (Figure 1) The review was conducted according to the PRISMA method and it distinguished 10 papers, which are presented in Table 1. Qualitative research • Subjective self-evaluation of the impact of lipoedema on health [28] Case study • Lipoedema and eating disorders [29] Pilot study • The connection between pain and psychological stress in people with lipoedema [20] Other study • Lipoedema comorbidities [30] • Left atrial and ventricular abnormalities in people with lipoedema [31] 3. Results…”

Section: Methodsmentioning

confidence: 99%

“…Four studies reported on the presence of comorbidities and all indicated the presence of hypothyroidism among their cohorts [23,24,26,30]. Overall, the largest proportion of patients included in these studies were obese (28%), and 27.5%, 22.7%, and 19.2% were affected by hypothyroidism, depression, and allergies respectively.…”

Section: Lipoedema Associated Comorbiditiesmentioning

confidence: 99%

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Lipoedema as a Social Problem. A Scoping Review

Czerwińska

Ostrowska

Hansdorfer-Korzon

2021

IJERPH

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(1) Background: Lipoedema is a disease characterized by excessive bilateral and symmetrical accumulation of subcutaneous tissue in the lower extremities. It is a poorly understood condition, and low awareness of its existence often leads to incorrect diagnosis Initially, lipoedema was considered to be completely independent of lifestyle Currently, however, more and more cases of the coexistence of lipoedema and obesity are described in the literature as additionally affecting the severity of the disease The aim of the review is to present lipoedema as a social problem. (2) Methods: Materials on lipoedema in the social context were selected from 2018–2021. The PRISMA-Scr checklist was used in the review. (3) Results: Research has shown that more than 3/4 of patients with lipoedema are also overweight or obese. Patients with lipoedema have many comorbidities, and their presence negatively affects the quality of life. The quality of life in patients with lipoedema is lower than in healthy patients. (4) Conclusions: The number of studies available on lipoedema is low. Obesity is common in patients with lipoedema. Mental disorders increase the level of experienced pain. Lipoedema significantly reduces quality of life. A healthy lifestyle in patients with lipoedema could be helpful for prevention of complications and disability.

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“…A symmetric accumulation of painful adipose tissue, especially in the limbs, is characteristic and leads to a disproportionate tissue distribution [ 1 , 2 , 10 ]. While the legs are almost always affected, the arms are more often affected in higher stages [ 4 , 11 , 12 ]. Pain in the adipose tissue is one of the most common symptoms, which causes a lot of limitation in everyday and professional life [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Characteristics and Patient Reported Outcome Measures in Lipedema Patients—Establishing a Baseline for Treatment Evaluation in a High-Volume Center

Hamatschek

Knors

Klietz

et al. 2022

JCM

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Lipedema patients suffer not only from visual stigma but also reduction in their quality of life through pain and performance loss in daily life. In clinical practice, it is still difficult to reliably diagnose the disease. This study aims to provide further insights into the characteristics of lipedema patients of all stages and provide a baseline prior to surgery for a surgical treatment evaluation by means of patient-reported outcome measures. Methods: Patients completed a lipedema-specific questionnaire containing 50 items, the World Health Organization Quality of Life BREF (WHOQOL-BREF) and the Patient Health Questionnaire 9 (PHQ-9). The data were analyzed using SPSS statistics 27. Patients who had already received liposuction were excluded. Results: Five hundred and eleven patients were included, of whom 337 completed the PHQ9 and 333 completed the WHOQOL-BREF questionnaires. The general characteristics of lipedema patients, especially the daily symptoms, are described. Previous observations, such as the frequent occurrence of hypothyroidism and the low rate of type 2 diabetes, were confirmed. Over 49% suffer from severe impairments in their jobs, whereby the disease shows a familial accumulation. The results of the WHOQOL-BREF and the PHQ-9 suggest a high level of mental stress. Discussion: As surgical intervention in lipedema patients is gaining traction, its effects should be well-documented. Therefore, a comprehensive baseline needs to be established prior to surgical treatment. The psychological components are just as important as the inclusion of daily impairments.

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Disease progression and comorbidities in lipedema patients: A 10‐year retrospective analysis

Cited by 23 publications

References 38 publications

Management of Lipedema with Ketogenic Diet: 22-Month Follow-Up

Management of Lipedema with Ketogenic Diet: 22-Month Follow-Up

Lipoedema as a Social Problem. A Scoping Review

Characteristics and Patient Reported Outcome Measures in Lipedema Patients—Establishing a Baseline for Treatment Evaluation in a High-Volume Center

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