Disease prevention strategies using vitamin D

Wimalawansa, Sunil J.

doi:10.25082/ahb.2019.02.005

Cited by 2 publications

(2 citation statements)

References 31 publications

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“…Having a strong immune system expedite the process of neutralizing and destroying COVID-19 and other infections. The key component that enhances the immune response is vitamin D [16], which also counters the pro-inflammatory cytokines and upregulates ACE-2 receptors. These actions initiate following binding of calcitriol to intracellular vitamin D receptors (VDRs) that promote the transcription of the ACE-2 gene, antimicrobial peptides, etc.…”

Section: The Mode Of Entry Of Covid-19 Into Human Cellsmentioning

confidence: 99%

Current Status and Prevention of COVID-19What Do We Know?

2020

AHS

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COVID-19 spread across the world, like a wildfire during the first half of the year 2020. It coincided with the flu season in countries located in northern and southern latitudes, during their respective winter periods. Whereas in the middle east, during its summertime people develop hypovitaminosis D, when people completely avoid the sun due to extreme heat. Consequently, people stay away from the hot sun and consequently, vitamin D concertation and the innate immunity reduce, increaseing the risks of acquiring respiratory viral infections. Thus, it is not necessary the low temperature and high humidity but the lack of exposure to ultraviolet (UV) B rays from the sunlight that reduces the population vitamin D concentration, which weakens the immunity, thereby increasing the risk of contracting COVID-19, and to develop associated complications and deaths. The effective public health modes for prevention of COVID-19 includes, wearing face masks properly covering nose and mouth, avoid crowd gatherings, especially in enclosed spaces, washing hands each time returned to office or home, and having a balance diet with adequate micronutrients, and these use of UVC lamps. At present there is no specific antiviral, or safe, effective, and affordable vaccine against COVID-19; it is unlikely such would materialize during the year 2020 or even beyond. At present, the only proven intervention that prevent COVID-19 and reduces its complications and deaths is vitamin D.

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Section: The Mode Of Entry Of Covid-19 Into Human Cellsmentioning

confidence: 99%

Current Status and Prevention of COVID-19What Do We Know?

2020

AHS

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“…The circulating concentration of vitD is tightly regulated and acts through a speci c receptor (VDR) to mediate its genomics actions. (4,10) The variability in vitamin D status and the severity of its de ciency are likely to be multifaceted, depending on various genetic, environmental and personal factors (11,12). Environmental factors, such as ethnicity, latitude, sun exposure and season, determine whether there is su cient UVB radiation to stimulate dermal vitD synthesis (13,14).…”

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confidence: 99%

Prediction algorithms using genetic and non genetic factors inducing vitamin D deficiency among healthy adults

AMMAR,

ABDERRAHMANE,

HENI

et al. 2024

Preprint

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Objective An alarming increase in vitamin D (vitD) deficiency even in sunny regions highlights the need for a better understanding of the mechanisms controlling vitD variability. We aimed to study potential variables involved in vitD deficiency among healthy Tunisian adults in order to establish two prediction algorithms: a composite algorithm (CA) that included genetic and non genetic factors and a simple one (SA) including only environmental non genetic factors. These algorithms could be used to predict vitD status and help identify individuals at high risk of vitD deficiency. Methods We screened six key genes (DBP, CYP2R1, CYP27B14, CYP24A1 and VDR) within the vitD metabolic pathway using 15 single nucleotide polymorphism (SNP) markers in across a cohort of 394 unrelated healthy individuals. After giving an informed consent, all participants were asked to complete a generalized questionnaire. Significant confounding factors that may influence the variability in serum 25(OH)D levels were used as covariates for association analyses. Statistical study was carried out with SPSS26.0. Results VitD deficiency correlated positively with albumin (r = 0.135, p = 0.007) and negatively with serum PTH (r = − 0.303, p < 0.001), age (r = − 0.198, P < 0.001), and BMI (r = − 0.143, p = 0.04). Multivariate logistic regression revealed that season, sun screen use, phototype, age, VDR- rs2228570 and CYP24A1- rs6013897 were significant predictors of hypovitaminosis D. Non genetic factors explained 15.6% of the variance in 25(OH)D concentrations while genetic polymorphisms (VDR- rs2228570 and CYP24A1- rs6013897) explained a lower variance of 12%. When combined together, genetic and non genetic factors contributed up to 27.6% in 25(OH)D concentrations variability. Conclusion 25(OH)D deficiency is highly prevalent among healthy adults in Tunisia. It is related to seasonal fluctuations, increasing age, darker skin tones, excessive sunscreen usage, and genetic polymorphisms in the VDR and CYP24A1 genes. The genetic markers could be used as tools in Mendelian randomization analyses of vitD, and they should well be considered when establishing a supplementation protocol in order to prevent 25(OH)D deficiency in the Tunisian population.

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Disease prevention strategies using vitamin D

Cited by 2 publications

References 31 publications

Current Status and Prevention of COVID-19What Do We Know?

Current Status and Prevention of COVID-19What Do We Know?

Prediction algorithms using genetic and non genetic factors inducing vitamin D deficiency among healthy adults

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