Disease Mechanisms in psoriasis and psoriatic arthritis

Costello, Patrick; FitzGerald, Oliver

doi:10.1007/s11926-996-0013-7

Cited by 11 publications

(8 citation statements)

References 55 publications

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“…The lesions are infiltrated by inflammatory cells, but a marked increase in proliferation and turnover of keratinocytes distinguish psoriasis from other inflammatory skin diseases. The disease has a strong but complex genetic basis, with a concordance rate of 50%-70% among MZ twins (Farber et al 1974;Eastmond 1994;Costello and FitzGerald 2001). Several genetic loci have been suggested, but only a major histocompatability (MHC) locus on chromosome 6 has been independently reported by at least two groups as significant genomewide (Elder et al 2001).…”

Section: Introductionmentioning

confidence: 99%

A Susceptibility Gene for Psoriatic Arthritis Maps to Chromosome 16q: Evidence for Imprinting

Kárason

Guðjónsson

Upmanyu

et al. 2003

The American Journal of Human Genetics

166

109

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Several genetic loci have been reported for psoriasis, but none has been specifically linked to psoriatic arthritis (PsA), a condition that affects >10% of patients with psoriasis. A genetic component for PsA is suggested by segregation within families and high concordance among identical twins. We performed a linkage scan to map genes contributing to PsA. We identified 178 patients with PsA out of 906 patients who were included in our genetic study of psoriasis. Using a comprehensive genealogy database, we were able to connect 100 of these into 39 families. We genotyped the patients using a framework marker set of 1,000 microsatellite markers, with an average density of 3 cM, and performed multipoint, affected-only, allele-sharing linkage analysis using the Allegro program. On the basis of the initial results, we genotyped more markers for the most prominent loci. A linkage with a LOD score of 2.17 was observed on chromosome 16q. The linkage analysis, conditioned on paternal transmission to affected individuals, gave a LOD score of 4.19, whereas a LOD score of only 1.03 was observed when conditioned for maternal transmission. A suggestive locus on chromosome 16q has previously been implicated in psoriasis. Our data indicate that a gene at this locus may be involved in paternal transmission of PsA.

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Section: Introductionmentioning

confidence: 99%

A Susceptibility Gene for Psoriatic Arthritis Maps to Chromosome 16q: Evidence for Imprinting

Kárason

Guðjónsson

Upmanyu

et al. 2003

The American Journal of Human Genetics

166

109

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“…We propose a working hypothesis of how IL-20 may be involved in the disease process summarized in the Figure 2. Epidemiological studies have demonstrated an association between the increased morbidity of atherosclerosis and RA [69,70] and between the increased morbidity of RA and psoriasis [71][72][73][74]. Angiogenesis plays a crucial role in the pathogenesis of psoriasis and RA, and in the progression of atherosclerosis plaque.…”

Section: Discussionmentioning

confidence: 99%

IL-20: biological functions and clinical implications

Wei

Hsu

et al. 2006

J Biomed Sci

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“…The well‐documented familial aggregation and the high concordance rate in monozygotic and dizygotic twins provide strong evidence of the importance of genetic factors in PsA. Several recent reports have reviewed the linkage between PsA and specific HLAs, such as B13, B16 (B38/B39), B17 (B57), Cw6 and DR4 (8–11). In particular, HLA‐B27 has been related to spine involvement (12).…”

Section: Discussionmentioning

confidence: 99%

Psoriasis Arthropathy and HLA‐B51: Report of 5 Cases

Yamamoto

Yokozeki

Nishioka

2005

The Journal of Dermatology

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Psoriasis arthropathy (PsA) is a chronic inflammatory arthropathy characterized by the association of arthritis with psoriasis. Although the precise mechanisms of PsA still remain obscure, several genetic and environmental factors have been suggested to play important roles. HLA-B51 has been strongly associated with Behçet's disease; however, its association with PsA has not been documented. We describe herein five Japanese patients (4 males and 1 female) with PsA and positive for HLA-B51. The clinical forms defined by Moll and Wright revealed that the polyarticular pattern was noted in two cases, and oligoarticular, distal, and spondyloarthropathy patterns were noted in one case each. Positive rheumatoid factor was detected in one patient, and antinuclear antibody in two patients. The other HLA subclasses were A2 and A31 in 3 cases, respectively. HLA-B51 was detected in 5 out of 17 patients with PsA examined in our department; in contrast, HLA-B51 was not detected in 17 patients with psoriasis vulgaris. Our observations suggest that HLA-B51 may play a role in the pathogenesis of PsA in the Japanese population.

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Disease Mechanisms in psoriasis and psoriatic arthritis

Cited by 11 publications

References 55 publications

A Susceptibility Gene for Psoriatic Arthritis Maps to Chromosome 16q: Evidence for Imprinting

A Susceptibility Gene for Psoriatic Arthritis Maps to Chromosome 16q: Evidence for Imprinting

IL-20: biological functions and clinical implications

Psoriasis Arthropathy and HLA‐B51: Report of 5 Cases

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