Disease duration and arcuate fasciculus abnormalities correlate with psychoticism in patients with epilepsy

Mao, Lingyan; Ding, Jing; Peng, Weifeng; Ma, Yu; Zhang, Yuhao; Chen, Caizhong; Cheng, Wei; Wang, He; Fan, Wei; Wang, Xin

doi:10.1016/j.seizure.2011.07.002

Cited by 8 publications

(11 citation statements)

References 37 publications

(51 reference statements)

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“…Full text was screened in 71 cases and reference lists were inspected to detect additional studies not identified with the initial search. Forty-two studies met the inclusion criteria for the meta-analysis (Ahmadi et al, 2009, Andrade et al, 2014, Arfanakis et al, 2002, Braakman et al, 2014, Campos et al, 2015, Concha et al, 2005, Concha et al, 2007, Concha et al, 2009, Deppe et al, 2008, Diao et al, 2015, Diehl et al, 2008, Duning et al, 2010, Gao et al, 2012, Govindan et al, 2008, Gross et al, 2006, Holt et al, 2011, Hutchinson et al, 2010, Keller et al, 2011, Keller et al, 2012, Kemmotsu et al, 2011, Kemmotsu et al, 2014, Kim et al, 2011, Knake et al, 2009, Kori et al, 2013, Labate et al, 2015, Lee et al, 2013, Lee et al, 2014, Li et al, 2010, Liacu et al, 2012, Lin et al, 2008, Liu et al, 2011, Mao et al, 2011, McDonald et al, 2008, Meng et al, 2010a, Nilsson et al, 2008, Powell et al, 2007, Pustina et al, 2015, Rodrigo et al, 2007, Scanlon et al, 2013, Vulliemoz et al, 2011, Wang et al, 2010, Xiao et al, 2014). The total number of people with epilepsy and controls was 1027 and 1122, respectively.…”

Section: Resultsmentioning

confidence: 99%

White matter abnormalities at a regional and voxel level in focal and generalized epilepsy: A systematic review and meta-analysis

Slinger

Sinke

Braun

et al. 2016

NeuroImage: Clinical

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ObjectiveSince the introduction of diffusion tensor imaging, white matter abnormalities in epilepsy have been studied extensively. However, the affected areas reported, the extent of abnormalities and the association with relevant clinical parameters are highly variable. We aimed to obtain a more consistent estimate of white matter abnormalities and their association with clinical parameters in different epilepsy types.MethodsWe systematically searched for differences in white matter fractional anisotropy and mean diffusivity, at regional and voxel level, between people with epilepsy and healthy controls. Meta-analyses were used to quantify the directionality and extent of these differences. Correlations between white matter differences and age of epilepsy onset, duration of epilepsy and sex were assessed with meta-regressions.ResultsForty-two studies, with 1027 people with epilepsy and 1122 controls, were included with regional data. Sixteen voxel-based studies were also included. People with temporal or frontal lobe epilepsy had significantly decreased fractional anisotropy (Δ –0.021, 95% confidence interval –0.026 to –0.016) and increased mean diffusivity (Δ0.026 × 10–3 mm2/s, 0.012 to 0.039) in the commissural, association and projection white matter fibers. White matter was much less affected in generalized epilepsy. White matter changes in people with focal epilepsy correlated with age at onset, epilepsy duration and sex.SignificanceThis study provides a better estimation of white matter changes in different epilepsies. Effects are particularly found in people with focal epilepsy. Correlations with the duration of focal epilepsy support the hypothesis that these changes are, at least partly, a consequence of seizures and may warrant early surgery. Future studies need to guarantee adequate group sizes, as white matter differences in epilepsy are small.

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Section: Resultsmentioning

confidence: 99%

White matter abnormalities at a regional and voxel level in focal and generalized epilepsy: A systematic review and meta-analysis

Slinger

Sinke

Braun

et al. 2016

NeuroImage: Clinical

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“…In all studies the temporal onset of seizures was confirmed by seizure recordings. We excluded several other DTI studies in people with epilepsy (Thivard et al., 2005; Powell et al., 2007; Focke et al., 2008; Yogarajah et al., 2008; Schoene‐Bake et al., 2009; Bhardwaj et al., 2010; Liacu et al., 2010; Liao et al., 2010; Riley et al., 2010; Afzali et al., 2011; Holt et al., 2011; Mao et al., 2011), because of heterogeneity in the patient group, postoperative instead of preoperative DTI, or different processing of white matter (e.g., voxel‐based analysis).…”

Section: Resultsmentioning

confidence: 99%

A meta‐analysis of white matter changes in temporal lobe epilepsy as studied with diffusion tensor imaging

et al. 2012

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SUMMARYPurpose: Diffusion tensor imaging (DTI) is used increasingly to study white matter integrity in people with temporal lobe epilepsy (TLE). Most studies report fractional anisotropy (FA) decrease and mean diffusivity (MD) increase in multiple white matter regions. The disturbance of white matter integrity varies across studies and between regions. We aimed to obtain a more consistent estimate of white matter diffusion characteristics and relate these to the distance from the seizure focus. Methods: Studies comparing diffusion characteristics of people with epilepsy with those of healthy controls were systematically reviewed and quantified using random and mixed effects meta analysis. In addition to the overall metaanalysis, pooled FA and MD differences were determined per hemisphere and white matter category separately. Key Findings: We included 13 cross-sectional studies. The pooled FA difference for all white matter was )0.026 (95% confidence interval [CI] )0.033 to )0.019) and MD difference was 0.028 · 10 )3 mm 2 /s (95% CI 0.015-0.04). FA was reduced significantly in people with TLE compared with healthy controls in both ipsilateral (mean difference )0.03) and contralateral white matter ()0.02). MD was significantly increased ipsilaterally and contralaterally. MD differed significantly between white matter connected to the affected temporal lobe and remote white matter. Significance: The meta-analysis provides a better estimation of the true diffusion characteristics. White matter structural integrity in TLE is disturbed more severely in the ipsilateral than in the contralateral hemisphere, and tracts closely connected with the affected temporal lobe are most disturbed. The exact underlying mechanisms remain to be elucidated.

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“… Sundram et al (2012) reported that antisocial personality disorder ( n = 30: 15 cases, 15 controls)—which in turn is linked to low agreeableness and low conscientiousness ( Lynam and Widiger, 2001 )—was negatively associated with FA in several regions, including the genu of the corpus callosum and the right uncinate fasciculus. Finally, Mao et al (2011) reported that psychoticism measured using the Eysenck Personality Questionnaire—which is noted to be a combination of agreeableness and conscientiousness (e.g. McCrae and Costa, 1985 )—was related to FA in the arcuate fasciculus ( r = −0.29, −0.36: L/R hemisphere, respectively) in a sample of patients with epilepsy ( n = 65); no significant correlations with neuroticism or extraversion were observed.…”

Section: Introductionmentioning

confidence: 98%

Trait conscientiousness and the personality meta-trait stability are associated with regional white matter microstructure

Lewis

Cox

Booth

et al. 2016

Social Cognitive and Affective Neuroscience

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Establishing the neural bases of individual differences in personality has been an enduring topic of interest. However, while a growing literature has sought to characterize grey matter correlates of personality traits, little attention to date has been focused on regional white matter correlates of personality, especially for the personality traits agreeableness, conscientiousness and openness. To rectify this gap in knowledge we used a large sample (n > 550) of older adults who provided data on both personality (International Personality Item Pool) and white matter tract-specific fractional anisotropy (FA) from diffusion tensor MRI. Results indicated that conscientiousness was associated with greater FA in the left uncinate fasciculus (β = 0.17, P < 0.001). We also examined links between FA and the personality meta-trait ‘stability’, which is defined as the common variance underlying agreeableness, conscientiousness, and neuroticism/emotional stability. We observed an association between left uncinate fasciculus FA and stability (β = 0.27, P < 0.001), which fully accounted for the link between left uncinate fasciculus FA and conscientiousness. In sum, these results provide novel evidence for links between regional white matter microstructure and key traits of human personality, specifically conscientiousness and the meta-trait, stability. Future research is recommended to replicate and address the causal directions of these associations.

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Disease duration and arcuate fasciculus abnormalities correlate with psychoticism in patients with epilepsy

Abstract: Long disease duration and impairment of arcuate fasciculus integrity may predispose the development of psychoticism in patients with epilepsy. Our results provide important insights into the pathophysiological mechanisms underlying personality change in epilepsy.

Cited by 8 publications

References 37 publications

White matter abnormalities at a regional and voxel level in focal and generalized epilepsy: A systematic review and meta-analysis

White matter abnormalities at a regional and voxel level in focal and generalized epilepsy: A systematic review and meta-analysis

A meta‐analysis of white matter changes in temporal lobe epilepsy as studied with diffusion tensor imaging

Trait conscientiousness and the personality meta-trait stability are associated with regional white matter microstructure

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