Disease disclosure, treatment adherence, and behavioural profile in a cohort of vertically acquired HIV-infected adolescents. NeuroCoRISpeS study

Medín, Gabriela; García-Navarro, Cristina; Gómez, Marisa Navarro; Mellado, María José; Jiménez, Santiago; Muñoz‐Fernández, María Ángeles; Conejo, Pablo Rojo; Saavedra, Jesús; Hortelano, M. García López; Guillén, Sara; González-Tomé, María Isabel

doi:10.1080/09540121.2015.1071768

Cited by 21 publications

(22 citation statements)

References 32 publications

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“…The increased psychosocial problems in HIV-infected adolescents were consistent with a previous study which revealed that HIV-infected adolescents had scored a risk of emotional and behavioral problems, identified from the SDQ as 24.5% [11]. Stigmatization and discrimination may be one of the factors that these adolescents have experienced so that these could affect peer relationship and Prosocial behaviors [14,27].…”

Section: Discussionsupporting

confidence: 78%

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Evaluation of Psychosocial Adjustment and Self-Esteem in Perinatally HIV-Infected Adolescents

Louthrenoo¹

2018

BJSTR

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Section: Discussionsupporting

confidence: 78%

“…In a cohort study, emotional and behavioral problems were found in 24.5% of HIV-infected adolescents [11]. Similarly, the prevalence of mental health problems was reported to be 29% in a study of children with perinatal HIV infection [12].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Psychosocial Adjustment and Self-Esteem in Perinatally HIV-Infected Adolescents

Louthrenoo¹

2018

BJSTR

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“…It is common that perinatally HIV-infected youth started to be sexually active while still under the care of paediatric health services. [ 22 , 23 ] When analysed, perinatally HIV-infected youth have not always had an adequate knowledge about their disease. [ 23 ] Unprotected sexual intercourse may be not so uncommon, leading to unintended pregnancies.…”

Section: Discussionmentioning

confidence: 99%

“…[ 22 , 23 ] When analysed, perinatally HIV-infected youth have not always had an adequate knowledge about their disease. [ 23 ] Unprotected sexual intercourse may be not so uncommon, leading to unintended pregnancies. [ 23 , 24 ] The discussions with HIV-infected adolescents may not focus only on the prevention of sexually transmitted infections but also on family planning.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy outcomes in perinatally HIV-infected young women in Madrid, Spain: 2000-2015

et al. 2017

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BackgroundAn increasing number of perinatally HIV-infected women (PHIV) are reaching adulthood and becoming pregnant. Most PHIV women have been exposed to a high number of antiretroviral regimens, and they may have difficulties to achieve viral suppression. Psychosocial problems are not uncommon and could be an important barrier for treatment adherence. The effects of chronic HIV infection and long-term exposure to antiretroviral treatment of PHIV women cause concerns on the developing fetus. The aims of this study were to describe the prevention of mother-to-child transmission strategies in PHIV women and the infant outcomes in the Madrid Cohort of HIV-infected mother-infant pairs.MethodsAll PHIV pregnant women registered in the Cohort that gave birth from 2000 to 2015 were included in the study.ResultsTwenty-eight pregnancies in twenty-two perinatally infected women were registered. Most women were Caucasian and heavily treatment-experienced. Nine cases (32.1%) were at high risk of HIV mother-to-child transmission. Maternal HIV-1 viral load was detectable close to delivery in four women (14.3%). The management of these cases was described, and the treatment strategies were discussed. None of the newborns acquired HIV infection. Eight infants (28.6%) were small for gestational age.ConclusionsThis study included a large series of pregnancies among PHIV women attended according to a youth-centered care model. The challenges in the management of this population by health-care providers were described. Specific strategies to minimize perinatal transmission risks should be addressed in future collaborative studies.

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“…This work is included in a prospective and ongoing cohort study (NeuroCoRISpe) to analyze the psychosocial, neurocognitive, and neuroimaging profile of vertically HIV-infected children. [26][27][28] This manuscript focuses on the cross-sectional assessment of their SQ.…”

Section: Participants and Proceduresmentioning

confidence: 99%

Sleep Profile and Self-Reported Neuropsychiatric Symptoms in Vertically HIV-Infected Adolescents on cART

González-Tomé

García-Navarro

Ruiz-Saez

et al. 2018

J Pediatr Infect Dis

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Background Sleep quality (SQ) data in human immunodeficiency virus (HIV) pediatric population are scarce. Our main objective was to assess SQ in our cohort and to determine the impact of antiretroviral therapy (ART) on sleep in a cohort of HIV-infected adolescents on cART. Materials and Methods The SQ was assessed through the Pittsburgh Sleep Quality Index (PSQI). Neuropsychiatric symptoms (NS) were recorded using an auto-administered questionnaire. To determine the antiretroviral (ARV) impact of efavirenz (EFV) on SQ, patients on EFV versus protease inhibitors-based regimens were compared. Results Forty-six patients were evaluated (median age: 16 years, interquartile range [IQR]: 10.8, 17)). Age at the start of ART: 1.3 years (0.4, 5.2); 23.9% showed acquired immunodeficiency syndrome (AIDS) category. Median CD4 at baseline was 656 (550, 808) cells/mm3; 91.3% had viral load <50 copies/mL. Median time on cART was 11.3 years (7.5, 15.2). Fifty-two percent of the patients were on EFV-based regimen. No differences were found in clinical and immunovirological variables although patients on EFV were older and were exposed for a longer time to ARV. Poor SQ was found in 26.1% of patients. Most frequent complaints were: sleep disturbances (76.1%), sleep latency (63%), and daytime dysfunction (54.3%). Similarly, there were no significant differences in NS between both treatment groups according to patients' reports but were significantly more common in bad sleepers. Patients on EFV-based regimen were more likely to repeat one or more school grades after the adjustment for age at evaluation and nadir CD4 percentage (odds ratio [OR]: 14.421, confidence interval [CI] 95%: 1.207–172.249, p = 0.035). Conclusions Sleep complaints and NS are common among our cohort of HIV adolescents on long-term cART and interestingly, not only in those who were receiving EFV.

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Disease disclosure, treatment adherence, and behavioural profile in a cohort of vertically acquired HIV-infected adolescents. NeuroCoRISpeS study

Cited by 21 publications

References 32 publications

Evaluation of Psychosocial Adjustment and Self-Esteem in Perinatally HIV-Infected Adolescents

Evaluation of Psychosocial Adjustment and Self-Esteem in Perinatally HIV-Infected Adolescents

Pregnancy outcomes in perinatally HIV-infected young women in Madrid, Spain: 2000-2015

Sleep Profile and Self-Reported Neuropsychiatric Symptoms in Vertically HIV-Infected Adolescents on cART

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