Disease control, survival, and functional outcome after multimodal treatment for advanced‐stage tongue base cancer

Malone, James P.; Stephens, Julie; Grecula, J.C.; Rhoades, Chris A.; Ghaheri, Bobak A.; Schuller, David E.

doi:10.1002/hed.20012

Cited by 45 publications

(30 citation statements)

References 31 publications

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“…2 Unfortunately, advances in surgery, radiotherapy, and chemotherapy have offered limited progress in terms of overall patient survival as regional failure and distant tumor recurrences continue to account for the disconcerting mortality rates over the last 2 decades. 3,4 The single greatest determinant of long-term patient survival remains early lesion detection and effective treatment. Presently, noninvasive imaging methods are unable to characterize the tissue microstructures in the epithelium and subepithelial layers.…”

Section: Arch Otolaryngol Head Neck Surg 2006;132:1074-1081mentioning

confidence: 99%

In Vivo Optical Coherence Tomography of the Human Oral Cavity and Oropharynx

Ridgway¹,

Armstrong²,

Guo³

et al. 2006

Arch Otolaryngol Head Neck Surg

110

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Section: Arch Otolaryngol Head Neck Surg 2006;132:1074-1081mentioning

confidence: 99%

In Vivo Optical Coherence Tomography of the Human Oral Cavity and Oropharynx

Ridgway¹,

Armstrong²,

Guo³

et al. 2006

Arch Otolaryngol Head Neck Surg

110

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“…Despite concerted efforts to improve treatments, 5 year survival rates for patients with advanced stage oral squamous cell carcinoma (oral SCC) remain among the lowest of solid cancers. Furthermore, even for those persons who are cured, morbidity remains high due to loss of tissues that are critical for esthetics and function (2). Another significant concern for persons diagnosed with oral SCC is the potential for tumor recurrence or the development of a second primary cancer (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Formulation and In-Vitro and In-Vivo Evaluation of a Mucoadhesive Gel Containing Freeze Dried Black Raspberries: Implications for Oral Cancer Chemoprevention

et al. 2007

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Purpose-The purpose of these studies was to formulate mucoadhesive gels containing freeze dried black raspberries (FBR) and to determine optimum parameters for a subset of FBR bioactive compounds including anthocyanin stability, absorption and penetration in-vitro and in-vivo.Materials and Methods-Berry gels were prepared having FBR at 5% and 10% w/w and final pHs ranging from 3.5 to 7.5. A HPLC assay was developed to quantify and determine the stability of the anthocyanins in the gels. A single time-point study was performed to determine anthocyanin uptake when the gels were applied to oral mucosa. Penetration of anthocyanins into human oral tissue explants was determined as a function of gel pH and FBR content. A HPLC-mass spectroscopy assay was utilized to quantify the anthocyanin levels in human oral tissue explants, saliva, and blood.Results-The stability of anthocyanins in the gel was directly related to gel pH and storage temperature. Maximum stability of anthocyanins was found at lower pH (pH 3.5) and storage temperature (4°C). Anthocyanins contained in mucoadhesive berry gel formulations were readily absorbed into human oral mucosa tissue as evidenced by detectable blood levels within 5 min after gel application. There was a trend for greater penetration of anthocyanins into tissue explants for berry gels with a final pH of 6.5 versus pH 3.5.Conclusions-Formulation and characterization of a novel gel formulation for local delivery of chemopreventive compounds to human oral mucosal tissues has been described. The results show anthocyanin stability was dependent upon gel pH and storage temperature and also demonstrate that the gel composition is well-suited for absorption and penetration into the target oral mucosal tissue site.

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“…10 In the case of resectable OSCC, the use of adjuvant chemotherapy is controversial: Some institutions propose the use of neoadjuvant chemoradiation, whereas others follow the surgery and/or radiotherapy alone concept. 11,12 Established chemotherapy regimens contain a combination of 5-fluorouracil (5-FU) with platinum-containing drugs, such as cisplatin and carboplatin. During past years, various strategies combining chemotherapy with radiotherapy were tested for their capability to improve treatment outcome.…”

mentioning

confidence: 99%

STAT1 activation in squamous cell cancer of the oral cavity

Laimer¹,

Spizzo²,

Obrist³

et al. 2007

Cancer

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Thermal degradation of poly(dimethylsilylene) homopolymer (PDMS) and poly(tetramethyldisilylene‐co‐styrene) copolymer (PTMDSS) was investigated by pyrolysis‐gas chromatography and thermogravimetry (TG). PDMS decomposes by depolymerization, producing linear and cyclic oligomeric products, whereas PTMDSS decomposes by random degradation along the chain resulting in each monomeric product and various other combination products. The homopolymer was found to be much less stable than the copolymer. The decomposition mechanisms leading to the formation of various products are shown. The kinetic parameters of thermal degradation were evaluated by different integral methods using TG data. The activation energies of decomposition (E) for the homopolymer and the copolymer are found to be 122 and 181 kJ/mol, respectively, and the corresponding values of order of reaction are 1 and 1.5. The observed difference in the thermal stability and the values of the kinetic parameters for decomposition of these polymers are explained in relation with the mechanism of decomposition. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci, 2006

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Disease control, survival, and functional outcome after multimodal treatment for advanced‐stage tongue base cancer

Abstract: Although functional outcome may be decreased by certain surgical interventions and advanced T stage, the high rate of locoregional and distant disease control and excellent 2-year disease-specific survival supports an aggressive treatment regimen for advanced tongue base cancer.

Cited by 45 publications

References 31 publications

In Vivo Optical Coherence Tomography of the Human Oral Cavity and Oropharynx

In Vivo Optical Coherence Tomography of the Human Oral Cavity and Oropharynx

Formulation and In-Vitro and In-Vivo Evaluation of a Mucoadhesive Gel Containing Freeze Dried Black Raspberries: Implications for Oral Cancer Chemoprevention

STAT1 activation in squamous cell cancer of the oral cavity

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