Disease control in patients with ankylosing spondylitis in real clinical practice in Spain: Results of the MIDAS study

Miguel, Eugenio de; Fernández‐Carballido, Cristina; Gratacós, Jordi; Pablos, José L.; Juanola, Xavier; Ariza, Rafael Ariza; Terradas-Montana, Pau; Sanabra, Cristina; Sastré, C.

doi:10.1016/j.reuma.2022.01.004

Cited by 1 publication

(4 citation statements)

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“…Two different cohorts were included: 313 patients with AS and 313 patients with psoriatic arthritis. The inclusion and exclusion criteria, study design, study procedures and main results have already been published ( 10 ). The main objective of the MIDAS study was to evaluate the percentage of patients with controlled disease activity.…”

Section: Methodsmentioning

confidence: 99%

“…In the MIDAS study, a BASDAI score < 4 was considered low disease activity and a BASDAI score ≤ 2 as disease remission ( 11 ). Disease control was defined as reaching at least a BASDAI of low disease activity ( 10 ). Disease activity was also measured through the Ankylosing Spondylitis Disease Activity Score index using C-reactive protein (ASDAS-CRP), and the percentage of patients with an ASDAS-CRP score < 2.1 (low disease activity) and < 1.3 (inactive disease) was calculated.…”

Section: Methodsmentioning

confidence: 99%

“…Thus, the study was performed according to the guidelines on observational post-authorization studies for medicinal products for human use (Order SAS/3470/2009) of the Spanish Agency of Medicines and Medical Devices (AEMPS). The Ethical and Clinical Research Committee of the 12 de Octubre Hospital approved the study protocol, informed consent forms, and patient information (approval number 18/437) ( 10 ).…”

Section: Methodsmentioning

confidence: 99%

“…The level of significance was set as a two-tailed p < 0.05. Data were analyzed with Statistical Analysis System Enterprise Guide 7.15 ( 10 ).…”

Section: Methodsmentioning

confidence: 99%

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Disease activity indexes might not capture the same disease aspects in males and females with ankylosing spondylitis: A real-world nationwide analysis

Fernández‐Carballido¹,

Jovaní

Catalán

et al. 2022

Front. Med.

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BackgroundTo evaluate gender differences in disease activity and health status (HS) in patients with radiographic axial spondyloarthritis (r-axSpA)/ankylosing spondylitis (AS).MethodsAncillary analysis of the MIDAS study, an observational, non-interventional, cross-sectional and retrospective multicenter nationwide study to assess disease activity and its relationship with HS in clinical practice. Adult patients with AS diagnosis, fulfilling ASAS and modified New York criteria, treated for ≥3 months upon study inclusion according to clinical practice were included. The primary outcome was “disease control” assessed by the percentage of patients in remission and low disease activity (BASDAI and ASDAS-CRP scores). HS was evaluated using the ASAS health index (ASAS-HI). Patients' responses and characteristics were analyzed by gender.ResultsWe analyzed 313 patients with AS, 237 (75.7%) males and 76 (24.3%) females. A total of 202 (64.5%) patients had adequate disease control (BASDAI < 4); 69.2% of males [mean (SD) BASDAI 2.9 (2.1)] and 50.0% of females [mean (SD) BASDAI 3.8 (2.4); p = 0.01]. According to ASDAS-CRP, 57.5% of patients were adequately controlled (ASDAS-ID +ASDAS-LDA); 138 (58.2%) males and 42 (55.3%) females. The mean (SD) ASDAS-CRP was 1.9 (1.1); being 1.9 (1.0) in males and 2.0 (1.1) in females. Overall, the impact of AS on HS was low to moderate [mean (SD) ASAS-HI 5.8 (4.4)]; being 5.5 (4.4) for males and 6.8 (4.2) for females (p = 0.02).ConclusionThis study showed a higher proportion of females with AS and active disease using the BASDAI definition. When using the ASDAS-CRP definition these differences by gender were less pronounced. The impact of disease activity on HS appears to be higher in females than males.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…The level of significance was set as a two-tailed p < 0.05. Data were analyzed with Statistical Analysis System Enterprise Guide 7.15 ( 10 ).…”

Section: Methodsmentioning

confidence: 99%

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