Disease Control in Cutaneous Leishmaniasis Is Independent of IL-22

Abstract

Abecasis GR, Cherny SS, Cookson WO et al. (2002) Merlin-rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 30:97-101 Bapat B, Xia L, Madlensky L et al. (1996) The genetic basis of Muir-Torre syndrome includes the hMLH1 locus. Am J Hum Genet 59:736-9 Chakrabarty KH, Perks AG (1996) Ferguson-Smith syndrome: the importance of long term follow-up. Br J Plast Surg 49:497-8 Cribier B, Asch P, Grosshans E (1999) Differentiating squamous cell carcinoma from keratoacanthoma using histopathological criteria. Is it possible? A study of 296 cases. Dermatology 199:208-12 Feldman RJ, Maize JC (2007) Multiple keratoacanthomas in a young woman: report of a case emphasizing medical management and a review of the spectrum of multiple keratoacanthomas. Int J Dermatol 46:77-9 Giglia-Mari G, Sarasin A (2003) TP53 mutations in human skin cancers. Hum Mutat 21: 217-28 Goudie DR, D'Alessandro M, Merriman B et al. (2011) Multiple self-healing squamous epithelioma is caused by a disease-specific spectrum of mutations in TGFBR1. Nat Genet 43:365-9 Grzybowski (1950) A case of peculiar generalised epithelial tumors of the skin. Br J Dermatol 63:310-3 Kruse R, Rutten A, Lamberti C et al. (1998) Muir-Torre phenotype has a frequency of DNA mismatch-repair-gene mutations similar to that in hereditary nonpolyposis colorectal cancer families defined by the Amsterdam criteria. Am J Hum Genet 63:63-70 Muir E, Bell A, Barlow K (1967) Multiple primary carcinomata of the colon, duodenum, and larynx associated with keratoacanthomata of the face.

IL‐17A/F in Leishmania major‐resistant C57BL/6 mice

“…Supernatants were assessed for the amounts of IFNγ and IL‐4 (controls, data not shown), IL‐17A, IL‐17F, IL‐17E and IL‐22 (Figure A). As described before, higher levels of IFNγ and IL‐22 were found in LN cells from C57BL/6 mice, whereas IL‐4 and IL‐17A were predominantly released from BALB/c cells . Interestingly, levels of secreted IL‐17F were comparable from C57BL/6 to BALB/c LN cells.…”

Genetic variation in Interleukin-32 influence the immune response against New World Leishmania species and susceptibility to American Tegumentary Leishmaniasis

“…In addition, IL-22 presents proinflammatory and anti-inflammatory properties, promoting wound healing/repair by activationg epithelial cells and fibroblasts [64,65]. In L. major-or L. braziliensis-infected mice the production of IL-22 decreases the lesion size without any effect on parasite load, indicating that IL-22 is more associated with the control of inflammation and wound healing than with parasite control in cutaneous leishmaniasis [23,66]. The role of IL-17 in ATL has been studied.…”

Pro- and anti-inflammatory cytokines in cutaneous leishmaniasis: a review

“…139 However, conflicting results have been reported indicating an independence of IL-22 in host resistance of C57BL/6 mice to L. major. 140 Overall, although there are a few studies about the role of IL-22 in leishmaniasis, it seems that this cytokine has a protective role against Leishmania infection.…”