Disease Control after Radiotherapy for Adult Craniopharyngioma: Clinical Outcomes from a Large Single-Institution Series

Rutenberg, M.S.; Holtzman, Adam L.; Indelicato, Daniel J.; Huh, Soon; Rao, Dinesh; Fiester, Peter; Morris, Christopher G.; Tavanaiepour, Daryoush; Amdur, Robert J.

doi:10.1007/s11060-022-03983-z

Cited by 8 publications

(3 citation statements)

References 31 publications

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“…28 Because all these complications can reduce patients' quality of life and subtotal resection followed by adjuvant radiation has comparable LC rates, this method has been proposed as the preferred treatment strategy by some groups. 6,7,25,[31][32][33][34][35][36][37] It should also be noted that recurrent tumors may occur even from small islets of CP cells which can persist even after GTR, thus necessitating irradiation. 38 Carpenter et al 39 published the first CP irradiation results in 1937 and concluded that pituitary stalk tumors can be radioresistant.…”

Section: Discussionmentioning

confidence: 99%

Frameless Hypofractionated Gamma Knife Radiosurgery for Residual or Recurrent Craniopharyngioma

Samancı

Essibayi²,

Askeroglu³

et al. 2023

Neurosurgery

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BACKGROUND:The management of craniopharyngiomas is challenging, usually requiring multidisciplinary care. Gamma Knife radiosurgery (GKRS) is an essential technique for residual/recurrent craniopharyngiomas. OBJECTIVE: To evaluate the efficacy of frameless hypofractionated GKRS (hfGKRS) for craniopharyngioma and factors which affect tumor control and complications. METHODS: This retrospective study involved 24 patients managed with hfGKRS. Clinical and radiological data, tumor characteristics, and procedural details were analyzed. RESULTS: There were 15 (62.5%) female patients. The median age was 38.5 years (range, 3-66 years). The mean tumor volume was 2.4 (1.93) cm 3 , with a mean solid volume of 1.6 (1.75) cm 3 . The median marginal dose was 20 Gy (range, 18-25 Gy) delivered in a median of 5 fractions (range, 3-5). During a median radiological follow-up of 23.5 months (range, 12-50 months), tumor progression was noted in 5 (20.8%) patients. The 2-year and 4-year progression-free survival were 81.8% and 61.4%, respectively. No deaths were identified at a median clinical follow-up of 31.3 months (range, 12-54 months). Visual deficits attributable to progression were noted in 3 (12.5%) patients with pre-GKRS visual field defects. An additional 4 (16.7%) patients with pre-GKRS visual deficit developed new minor visual field defects. Four (16.7%) patients showed improvement of vision after GKRS. There were no new-onset post-GKRS hormonal deficits. CONCLUSION: The management of craniopharyngioma requires a multidisciplinary approach, and irradiation represents effective treatment option for residual/recurrent tumors after surgery. To the best of our knowledge, this is the first study that addresses the efficacy of frameless hfGKRS in managing craniopharyngiomas over sufficient follow-up.

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Section: Discussionmentioning

confidence: 99%

Frameless Hypofractionated Gamma Knife Radiosurgery for Residual or Recurrent Craniopharyngioma

Samancı

Essibayi²,

Askeroglu³

et al. 2023

Neurosurgery

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“…As such, gross total resection of the tumor remains recommended when there is no infiltration of the hypothalamus, while it is recommended to perform a subtotal tumor resection followed by adjuvant radiotherapy when hypothalamic infiltration is confirmed [ 71 ]. Radiotherapy in adults with CPs results in an excellent control rate of 100% at the five-year follow-up, and 94% at the 10-year follow-up [ 72 ]. Visual deterioration and endocrine deficiencies following radiotherapy may occur in 10% to 20% of patients [ 72 ].…”

Section: Future Directions For the Care Of Craniopharyngiomasmentioning

confidence: 99%

“…Radiotherapy in adults with CPs results in an excellent control rate of 100% at the five-year follow-up, and 94% at the 10-year follow-up [ 72 ]. Visual deterioration and endocrine deficiencies following radiotherapy may occur in 10% to 20% of patients [ 72 ].…”

Section: Future Directions For the Care Of Craniopharyngiomasmentioning

confidence: 99%

The Challenging Management of Craniopharyngiomas in Adults: Time for a Reappraisal?

Cuny

Buchfelder

Dufour

et al. 2022

Cancers

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Craniopharyngiomas (CPs) are rare tumors of the skull base, developing near the pituitary gland and hypothalamus and responsible for severe hormonal deficiencies and an overall increase in mortality rate. While surgery and radiotherapy represent the recommended first-line therapies for CPs, a new paradigm for treatment is currently emerging, as a consequence of accumulated knowledge concerning the molecular mechanisms involved in tumor growth, paving the way for anticipated use of targeted therapies. Significant clinical and basic research conducted in the field of CPs will undoubtedly constitute a real step forward for a better understanding of the behavior of these tumors and prevent associated complications. In this review, our aim is to summarize the multiple steps in the management of CPs in adults and emphasize the most recent studies that will contribute to advancing the diagnostic and therapeutic algorithms.

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Base of the Skull and Orbit

Nieder,

Astner,

Boeckh-Behrens

et al. 2023

Target Volume Definition in Radiation Oncology

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Disease Control after Radiotherapy for Adult Craniopharyngioma: Clinical Outcomes from a Large Single-Institution Series

Cited by 8 publications

References 31 publications

Frameless Hypofractionated Gamma Knife Radiosurgery for Residual or Recurrent Craniopharyngioma

Frameless Hypofractionated Gamma Knife Radiosurgery for Residual or Recurrent Craniopharyngioma

The Challenging Management of Craniopharyngiomas in Adults: Time for a Reappraisal?

Base of the Skull and Orbit

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