Disease concomitance in psoriasis

Henseler, Tilo; Christophers, Enno

doi:10.1016/0190-9622(95)91336-x

Cited by 634 publications

(589 citation statements)

References 22 publications

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“…39,40 Psoriasis was first associated with obesity in several large, epidemiologic studies from Europe. 33,41,42 Recently, a database from the UK has shown the BMI to be elevated in psoriasis patients. In severe psoriasis the BMI is higher than in mild psoriasis.…”

Section: Obesitymentioning

confidence: 99%

“…66 One series from Germany suggests that the rate of cutaneous infection in psoriatics is diminished when compared to a control population. 42 This may not be the case for infections of the respiratory tract. A large population based study in Sweden suggests that both males and females with psoriasis are at increased risk for pneumonia and systemic viral infections.…”

Section: Infectionmentioning

confidence: 99%

See 1 more Smart Citation

National Psoriasis Foundation clinical consensus on psoriasis comorbidities and recommendations for screening

Kimball

Gladman

Gelfand

et al. 2008

Journal of the American Academy of Dermatology

377

318

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Section: Obesitymentioning

confidence: 99%

Section: Infectionmentioning

confidence: 99%

National Psoriasis Foundation clinical consensus on psoriasis comorbidities and recommendations for screening

Kimball

Gladman

Gelfand

et al. 2008

Journal of the American Academy of Dermatology

377

318

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“…The strong expression of AMPs in psoriasis skin has been classically linked to the inability of a psoriatic plaque to be infected [20]. Recently, this AMP overexpression was also linked to the aberrant activation of pDC to produce IFN and the pathogenesis of psoriasis [21].…”

mentioning

confidence: 99%

“…Cathelicidins are a family of alpha-helical peptides containing LL37 as the only human member [14,15], β-defensins a family of beta-sheet peptides containing human beta-defensin (hBD)1, hBD2 [16], and hBD3 [17], and S100 proteins containing S100A7 (psoriasin) that is abundantly expressed in psoriatic skin [18,19]. Other AMPs overexpressed in psoriatic skin include RNase7, elafin, lysozyme, and neutrophil gelatinase associated lipocalin [10].The strong expression of AMPs in psoriasis skin has been classically linked to the inability of a psoriatic plaque to be infected [20]. Recently, this AMP overexpression was also linked to the aberrant activation of pDC to produce IFN and the pathogenesis of psoriasis [21].…”

mentioning

confidence: 99%

Cationic antimicrobial peptides in psoriatic skin cooperate to break innate tolerance to self‐DNA

et al. 2014

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Psoriasis is a T-cell-mediated skin autoimmune disease characterized by the aberrant activation of dermal dendritic cells (DCs) and the sustained epidermal expression of antimicrobial peptides. We have previously identified a link between these two events by showing that the cathelicidin antimicrobial peptide LL37 has the ability to trigger selfnucleic acid mediated activation of plasmacytoid DCs (pDCs) in psoriatic skin. Whether other cationic antimicrobial peptides exert similar activities is unknown. By analyzing heparin-binding HPLC fractions of psoriatic scales, we found that human beta-defensin (hBD)2, hBD3, and lysozyme are additional triggers of pDC activation in psoriatic skin lesions. Like LL37, hBD2, hBD3, and lysozyme are able to condense self-DNA into particles that are endocytosed by pDCs, leading to activation of TLR9. In contrast, other antimicrobial peptides expressed in psoriatic skin including elafin, hBD1, and psoriasin (S100A7) did not show similar activities. hBD2, hBD3, and lysozyme were detected in psoriatic skin lesions in the vicinity of pDCs and found to cooperate with LL37 to induce high levels of IFN production by pDCs, suggesting their concerted role in the pathogenesis of psoriasis.Keywords: Antimicrobial peptides r Plasmacytoid DC r Psoriasis r Skin r Toll-like receptor Additional supporting information may be found in the online version of this article at the publisher's web-site IntroductionPsoriasis is a common T-cell-mediated inflammatory disease of the skin, which, in its most prevalent form, is characterized by the appearance of scaly erythematous plaques that may cover large Correspondence: Dr. Michel Gilliet e-mail: Michel.gilliet@chuv.ch areas of the patient's body [1][2][3]. A key feature of psoriasis is the abnormal activation of dendritic cell (DC) subsets in the dermal compartment leading to the downstream T-cell-mediated autoimmune cascade [4]. A role for plasmacytoid DCs (pDCs) producing type I IFNs appears to be central in this process. pDC-derived * These authors contributed equally to this work.www.eji-journal.eu 204Roberto Lande et al. Eur. J. Immunol. 2015. 45: 203-213 IFNs activate conventional DCs that stimulate autoimmune T cells to migrate into the epidermis [5]. Here, these T cells produce Th17 cytokines 7], which directly initiate keratinocyte proliferation and an abnormal epidermal differentiation pattern [8,9]. Another key feature of psoriasis is the excessive production of antimicrobial peptides (AMPs) and proteins by keratinocytes [10][11][12]. These AMPs are best known for their role in killing pathogenic microorganisms such as Gram-positive and Gramnegative bacteria, protozoa, fungi, as well as some viruses [13]. The antimicrobial activity of AMPs has been ascribed to their unique cationic and amphiphatic structure, which allows interaction with and disruption of microbial membranes containing a high degree of negative charges. Three major antimicrobial peptide classes found in psoriatic skin are the cathelicidin, β-defensins, or S100 proteins. ...

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“…Obese patients were placed on an energy-restricted diet (high omega-3, low omega-6) and it was found that the Psoriasis Area and Severity Index (PASI) decreased by more than 50% after six months [41]. Studies suggest that a vegetarian diet may improve psoriasis [42][43][44][45].…”

Section: Psoriasismentioning

confidence: 99%

The Role of Nutrition in Dermatology

Sivamani¹

2017

Austin J Dermatolog

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EditorialNutrition plays a significant role in the overall health of humans. Skin health can be affected in a positive or negative way by the foods we consume [1][2][3]. With the growth in research of how diet and nutrition impact skin conditions, our understanding of nutritional influences in dermatology has grown as well. We explore the relationship between nutrition and common skin disorders, such as acne and atopic dermatitis. Acne

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Disease concomitance in psoriasis

Cited by 634 publications

References 22 publications

National Psoriasis Foundation clinical consensus on psoriasis comorbidities and recommendations for screening

National Psoriasis Foundation clinical consensus on psoriasis comorbidities and recommendations for screening

Cationic antimicrobial peptides in psoriatic skin cooperate to break innate tolerance to self‐DNA

The Role of Nutrition in Dermatology

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