Disease complexity in acute coronary syndrome is related to the patient's immunological status

Moro-García, Marco Antonio; Iglesias, Fernando López; Avanzas, Pablo; Echeverría, Ainara; López‐Larrea, Carlos; Morís, César; Alonso-Arias, Rebeca

doi:10.1016/j.ijcard.2015.04.063

Cited by 8 publications

(2 citation statements)

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“…Increased percentages of highly differentiated CD4 + T-cells were found in ACS patients compared to patients with nonobstructive coronary artery disease (CAD) and healthy controls. Furthermore, higher degree of CD4 + T-cell differentiation correlated with more diseased vessels, lower left ventricular ejection fraction, increased number of prior ACS events, and worse SYNTAX score, which is an angiographic grading tool to determine the complexity of the CAD [92]. Together, these studies suggest ACS is associated with aging of the adaptive immune system and this correlates with measurements of disease pathology.…”

Section: Cd4 + T-cellsmentioning

confidence: 82%

Adaptive Immune Responses in Human Atherosclerosis

Lee

Bartlett

Dwivedi

2020

IJMS

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Atherosclerosis is a chronic inflammatory disease that is initiated by the deposition and accumulation of low-density lipoproteins in the artery wall. In this review, we will discuss the role of T- and B-cells in human plaques at different stages of atherosclerosis and the utility of profiling circulating immune cells to monitor atherosclerosis progression. Evidence supports a proatherogenic role for intraplaque T helper type 1 (Th1) cells, CD4+CD28null T-cells, and natural killer T-cells, whereas Th2 cells and regulatory T-cells (Treg) have an atheroprotective role. Several studies indicate that intraplaque T-cells are activated upon recognition of endogenous antigens including heat shock protein 60 and oxidized low-density lipoprotein, but antigens derived from pathogens can also trigger T-cell proliferation and cytokine production. Future studies are needed to assess whether circulating cellular biomarkers can improve identification of vulnerable lesions so that effective intervention can be implemented before clinical manifestations are apparent.

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Section: Cd4 + T-cellsmentioning

confidence: 82%

Adaptive Immune Responses in Human Atherosclerosis

Lee

Bartlett

Dwivedi

2020

IJMS

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“…Moro-Garcia et al have shown that the patients who have acute coronary syndrome have higher immune response. 22 …”

Section: Introductionmentioning

confidence: 99%

Association of neutrophil/lymphocyte ratio with obstructive coronary artery disease and coronary artery calcium score detected by multislice computed tomography in type 2 diabetes mellitus patients

Aygün¹,

Efe²

2015

PPA

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ObjectiveThe aim of the present study was to investigate the association of neutrophil/lymphocyte ratio (NLR) with coronary artery calcium score (CACS) and obstructive coronary artery disease (CAD) detected by multislice computed tomography (MSCT) angiography in type 2 diabetes mellitus (T2DM) patients.MethodsTwo hundred and ninety-two T2DM patients, who were either asymptomatic or symptomatic (but noncharacteristic) for coronary artery disease (CAD) and underwent MSCT angiography in our clinic between May 2009 and June 2014, were enrolled. All patients were divided into two groups according to their mean NLR values. Patients with NLR ≤2.05 were assigned to Group 1 and patients with NLR >2.05 were assigned to Group 2. The association of NLR with CACS and obstructive CAD, which were detected by MSCT angiography, was investigated in T2DM patients.ResultsAccording to the Agatston scoring method, the mean CACS was 129.5±209.8 Au in Group 1 and 290.3±399.6 Au in Group 2 (P<0.001). Obstructive CAD was detected in 40 (26.8%) patients in Group 1 and in 56 (39.2%) patients in Group 2 (P<0.05, P<0.021).ConclusionThe rate of obstructive CAD was significantly higher in the T2DM patients with NLR >2.05 than that in the T2DM patients with NLR ≤2.05. In addition, the CACS was also significantly higher in the T2DM patients with NLR >2.05 than that in the T2DM patients with NLR ≤2.05.

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