Disease characteristics of psoriatic arthritis patients may differ according to age at psoriasis onset: cross-sectional data from the Psoriatic Arthritis-International Database

Abstract

ObjectiveTo explore the impact of early versus late-onset psoriasis (PsO) on the disease characteristics of psoriatic arthritis (PsA) in a large-multicentre cohort. MethodsThe data from a multicentre psoriatic arthritis database was analysed. Patients were grouped according to age at psoriasis onset (early onset; <40 years of age, late-onset; >40 years of age) and disease characteristics of the groups were compared by adjusting for BMI and PsA duration, where necessary. Results At the time of analyses, 1634 patients were recruited [62.8% females; early onset 1108 (67.8%); late-onset, 526 (32.2%)]. The late-onset group was more over-weight [66.8% vs. 86.8%, p<0.001; adjusted for age -aOR 1.55 (1.11-2.20; 95% CI)]. The early onset group had more scalp psoriasis at onset (56.7% vs. 43.0%, p<0.001), whereas extremity lesions were more common in the late-onset group (63.8% vs. 74.2%, p<0.001). Axial disease in males and psoriatic disease family history in females were significantly higher in the early onset group [38.0% vs. 25.4%; p=0.005; adjusted for PsA duration -aOR 1.76 (1.19-2.62; 95% CI) / 39.5% vs. 30.1%; p=0.003; OR 1.51 (1.15-1.99; 95% CI), respectively]. Psoriatic disease activity parameters, patient-physician reported outcomes and HAQ-DI scores were similar in both groups. Conclusion Clinical features of PsA may be affected by the age at onset of PsO. Different genetic backgrounds in early and late-onset PsO may be driving the differences in psoriasis and PsA phenotypes.

Relationship between onset of psoriasis and spondyloarthritis symptoms with clinical phenotype and diagnosis: data from REGISPONSER registry

“… 18 To our knowledge, there is no study with similar objectives to ours with psoriasis as a reference. Bilgin et al 19 observed differences in the phenotype of psoriasis without any important impact in terms of PsA in patients with an early onset (<40 years) and late onset (>50 years) of psoriasis.…”

Influence of age of onset of psoriasis on prevalence and clinical characteristics of psoriatic arthritis (according to the registry of patients with psoriasis)

“…У большей части (73%) пациентов с тяжелыми и средне-тяжелыми формами псориаза, включенных в регистр пациентов с псориазом РОДВК, отмечалось РНП, что согласуется с данными других авторов [1,2,5]. Как и в других исследованиях, пациенты с РНП были моложе и имели бóльшую продолжительность псориаза на момент включения в регистр [2,11,12].…”

“…Схожие результаты по возрасту установления диагноза псориаза (23,5±9,4 и 50,4±7,2 года соответственно) и ПсА (35,8±11,2 и 54,2±8,4 года соответственно) были получены E. Bilgin и соавт. [11].…”

“…Е. Biglin и соавт. [11] при обследовании 1 634 пациентов с ПсА обнаружили повышение частоты аксиального поражения как у мужчин, так и у женщин с РНП (статистически значимым оно было только у мужчин).…”

Dactylitis and Early Onset Psoriasis in Psoriatic Arthritis: Are they Markers of Disease Severity? A Clinical Study

“…A recent analysis in PsO patients confirmed that HLA alleles explain a larger heritability of EOP, moving towards a genetic profiling to predict the PsO risk of a more severe phenotype [ 5 ]. The PsO stratification age among PsA patients was also assessed, showing that it could play a role in the clinical and genetic features of PsA patients [ 6 , 7 ]. Furthermore, in PsA patients, LOP was described as an independent cardiovascular disease-associated factor [ 8 ].…”