Disease burden in individuals with symptomatic undiagnosed asthma or COPD

AL-Habeeb, F.F.; Whitmore, G. À.; Vandemheen, Katherine L.; FitzGerald, J. Mark; Bergeron, C.; Lemière, Catherine; Boulet, Louis‐Philippe; Field, Stephen K.; Penz, Erika; McIvor, R. Andrew; Gupta, Samir; Mayers, Irvin; Bhutani, Mohit; Hernández, Paul; Lougheed, Diane; Licskai, Christopher; Azher, Tanweer; Côté, Andréanne; Ainslie, Martha; Fraser, Ian; Mahdavian, Masoud; Aaron, Shawn D.

doi:10.1016/j.rmed.2022.106917

Cited by 5 publications

(2 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 12 Moreover, individuals with undiagnosed COPD had worse health-related quality of life compared to those without airflow obstruction. 15 Furthermore, compared to early diagnosis, late detection of COPD is related to higher exacerbation rate and increased comorbidities (such as cardiovascular disease, depression, osteoporosis and diabetes) and costs. 16 , 17 Overall, undiagnosed COPD imposes a substantial burden on both patients and the healthcare system as it results in a worsened quality of life for patients, increased likelihood of comorbidities and poor prognoses, and strains on healthcare resources.…”

Section: Key Points Of Copd Early Detectionmentioning

confidence: 99%

Current Progress of COPD Early Detection: Key Points and Novel Strategies

Lin¹,

Cheng²,

Chen³

et al. 2023

COPD

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide, with approximately 70% to 80% of adults with COPD being undiagnosed. Patients with undiagnosed COPD are at increased risk of poor outcomes and a worsened quality of life, making early detection a crucial strategy to mitigate the impact of COPD and reduce the burden on healthcare systems. In the past decade, increased interest has been focused on the development of effective strategies and instrument for COPD early detection. However, identifying undiagnosed cases of COPD is still challenging. Both screening and case-finding approaches have been adopted to identify undiagnosed COPD, with case-finding being recommended by the 2023 Global Initiative for Chronic Obstructive Lung Disease (GOLD) guideline and the updated United States Preventive Services Task Force (USPTF) recommendation. Nonetheless, the approaches, criteria, and instruments used for early detection of COPD are varied. However, advances in the taxonomy and risk factors of COPD are continuously being investigated. It is important to continuously assess the current state of knowledge on COPD early detection, given the challenges associated with identifying undiagnosed COPD. This review aims to highlight recent advances in early detection of COPD. To discuss the current challenge and opportunity in COPD early detection, providing an overview of existing literature on COPD case-finding strategies, including the approaches, criteria for subjects, and instruments. The review also summarizes the current progress in COPD case-findings and proposes a COPD case-finding flowchart as an efficient method for identifying at risk COPD patients.

show abstract

Section: Key Points Of Copd Early Detectionmentioning

confidence: 99%

Current Progress of COPD Early Detection: Key Points and Novel Strategies

Lin¹,

Cheng²,

Chen³

et al. 2023

COPD

View full text Add to dashboard Cite

show abstract

“…However, the generalizability of these studies is limited due to being conducted in single centres, with small sample sizes, and lack of a comprehensive symptom burden assessment which includes non-respiratory symptoms that are common among patients with COPD or lung cancer such as pain, fatigue, and poor mental health ( 5 - 10 ). Furthermore, little attention has been given to undiagnosed COPD, which can also be symptomatic ( 11 , 12 ). Undiagnosed COPD is very common among individuals at risk for ( 13 , 14 ) or with lung cancer ( 15 , 16 ).…”

Section: Introductionmentioning

confidence: 99%

Impact of chronic obstructive pulmonary disease on lung cancer symptom burden: a population-based study in Ontario, Canada

Butler,

Louie,

Sutradhar

et al. 2023

Transl Lung Cancer Res

View full text Add to dashboard Cite

Background Chronic obstructive pulmonary disease (COPD) and lung cancer commonly coexist and have significant symptom overlap. We sought to compare the symptom burden of lung cancer patients with COPD to those without COPD. Methods We conducted a retrospective, cross-sectional study of stage I–IV lung cancer patients in Ontario, Canada, who completed the Edmonton Symptom Assessment Scale (ESAS) within 90 days of diagnosis. COPD was ascertained using a validated algorithm and patients were grouped as: no COPD, previously diagnosed COPD (at least 90 days prior to lung cancer diagnosis), and newly diagnosed COPD (within 90 days of lung cancer diagnosis). The association between COPD status and any moderate to severe symptom (ESAS ≥4) and the number of moderate to severe symptoms was determined using multivariable modified Poisson regression analyses. Multivariable linear regression analysis was used to compare total symptom distress scores. Analyses were stratified by limited (I/II) and advanced stage (III/IV). Results Among 38,898 lung cancer patients, 53% had COPD (previously diagnosed 43%, newly diagnosed 10%). Collectively, those with previously diagnosed COPD had the most severe symptom burden. Across all stages, both COPD groups had a significantly higher risk of experiencing any (relative risk: 1.04 to 1.18) and multiple moderate to severe symptoms (RR 1.05 to 1.24), in addition to higher total symptom distress scores (P<0.0001). Differences in symptom burden between groups were most pronounced among early-stage patients. Conclusions Lung cancer patients with underlying COPD have worse symptom burden, indicating a need for interventions that effectively alleviate symptoms.

show abstract