Disease burden and productivity cost of chronic rhinosinusitis patients referred to a tertiary centre in Australia

Liu, Timothy; Cooper, Thomas J.; Earnshaw, James; Cervin, Anders

doi:10.21037/ajo.2018.01.03

Cited by 8 publications

(3 citation statements)

References 31 publications

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“…For a population facing significant obstacles, loss of daily functioning attributable to CRS symptoms may further complicate their ability to overcome socioeconomic barriers. 21 Determinants of quality of life is undoubtedly complex. However, we saw a moderate negative correlation between SNOT-22 and EQ-VAS scores (Figure 1), which suggests that severity of CRS symptoms may be an important factor in a homeless individual's perception of their overall health state.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Chronic Sinonasal Disease Symptoms in an Urban Homeless Population

Itamura

Hur

Ference

et al. 2020

Am J Rhinol�Allergy

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Background The urban homeless population has increased exposure to risk factors associated with chronic rhinosinusitis (CRS). However, a gap in knowledge of the prevalence of sinonasal symptoms in these demographic limits complete understanding of CRS epidemiology. There is a need to elucidate sinonasal disease burden in this vulnerable patient population to bring awareness to any existing disparities. Objective To assess the prevalence, severity, and associated factors of CRS clinical symptoms and health-care barriers in an urban homeless population. Methods Homeless adults completed a sociodemographic questionnaire and the 22-item Sinonasal Outcome Test (SNOT-22) and EuroQol-5 Dimension-3 Level-Visual Analog Scale surveys. Responses were categorized by potential CRS symptoms defined as reporting at least 2 CRS cardinal symptoms. Risk factors associated with potential CRS symptoms were analyzed with multivariate regression models. Results Fifty-six (16%) out of 341 total subjects reported potential CRS symptoms. Those with potential CRS symptoms had a higher median SNOT-22 score (53 vs 22, P < .001) than those without. Logistic regression models identified history of smoking (odds ratio [OR], 6.54; 95% confidence interval [CI], 2.04–21.04) and duration of homelessness over 3 months (OR, 3.46; CI, 1.51–7.94) as factors associated with potential CRS symptoms. Duration of homelessness over 3 months was associated with higher SNOT-22 scores (standardized beta coefficient [β], 0.48; CI, 0.39–0.57). Among those reporting 2 or more CRS cardinal symptoms, 18% had ever been seen by any physician for their symptoms. Conclusions Our study estimates a high prevalence of potential CRS symptoms in the urban homeless population. Longer duration of homelessness was associated with potential CRS symptoms and poor CRS-specific quality of life scores. Disparities in access to care emphasize the need for increased preventive efforts designed for this unique patient group.

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Section: Discussionmentioning

confidence: 99%

Characterization of Chronic Sinonasal Disease Symptoms in an Urban Homeless Population

Itamura

Hur

Ference

et al. 2020

Am J Rhinol�Allergy

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“…In Australia, chronic rhinosinusitis has been estimated to cost an overall annual productivity of AUD $10 893.84 per patient. 2 In the USA, the overall direct healthcare cost related to chronic rhinosinusitis is estimated to range between US $10 and $13 billion per year, and the indirect cost related to loss of work productivity is estimated to be more than US $20 billion. 3 There are an array of different medical therapies for chronic rhinosinusitis.…”

Section: Introductionmentioning

confidence: 99%

A systematic review and meta-analysis of the role of doxycycline in chronic rhinosinusitis

Chan¹,

Khalid

Ooi

2022

J. Laryngol. Otol.

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Objective The objective of this systematic review and meta-analysis was to evaluate the role of doxycycline in the management of chronic rhinosinusitis. Method This was a systematic review using Ovid Medline, Cinahl, Scopus and Cochrane and was limited to meta-analyses, systematic reviews and randomised, clinical trials. A combination of the following search terms was used: ‘sinusitis’, ‘nasal polyps’, ‘doxycycline’ and ‘tetracycline’. Raw means and standard deviations were extracted from the included studies. The meta-analysis was performed using mean differences of pre- versus post-doxycycline treatment. Results A total of 279 studies were screened, of which 5 studies met the criteria (all randomised, controlled trials published between 2010 and 2021). The interventions, endpoints and measured outcomes varied across all studies. Meta-analysis performed on pre- versus post-doxycycline treatment for Sino-Nasal Outcome Test-22, nasal polyp scores and symptom scores did not yield statistically significant results. Conclusion This review identified a small number of high-quality studies on the use of doxycycline in chronic rhinosinusitis. There does not seem to be convincing evidence for the routine use of doxycycline in patients with chronic rhinosinusitis. Further research may try to identify certain phenotypes of chronic rhinosinusitis that may better respond to doxycycline.

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“…Sinonasal symptoms occur frequently and may arise from conditions such as rhinosinusitis, septal deviation, and allergic rhinitis 1‐4 . Chronic rhinosinusitis (CRS) alone affects 2.1% to 11.6% of adults, 1,2 with a significant associated economic and societal burden and cost 5‐7 . Nasal obstruction is also highly prevalent and negatively impacts health status, 3 as does allergic rhinitis, which affects 1 in 6 Americans at a cost of 2 to 4 billion dollars per annum 8 .…”

mentioning

confidence: 99%

The Impact of Sinonasal Symptoms in Relation to Potentially Life‐Threatening Comorbidities

Zhou

Prince

Maxfield

et al. 2023

Otolaryngol.--head neck surg.

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ObjectiveWhile general health may be influenced by sinonasal symptoms, their effects may be overshadowed by comorbid states which may be more serious. To assess the validity of this postulate, we measured the extent to which sinonasal symptoms and concurrent conditions influenced general health.Study DesignObservational outcomes study.SettingAcademic medical center, community care sites.MethodsAdults with sinonasal symptoms completed the 22‐item Sinonasal Outcome Test, along with the Patient‐Reported Outcomes Measurement Information System global health short form. Comorbidities were categorized with the Deyo modification of the Charlson comorbidity index. Multivariate regression analyses were utilized to determine the relative impact of sinonasal symptoms and concurrent comorbid conditions on general health.ResultsData from 219 consecutive patients demonstrated that sinonasal symptoms were associated with significantly diminished general physical (β = −1.431, p < .001), mental (β = −1.000, p < .001), overall (β = −1.026, p < .001), and social health (β = −0.872, p = .003), regardless of the presence of potentially life‐threatening comorbid conditions. Comorbid conditions included cardiovascular disease, chronic obstructive pulmonary disease, connective tissue disease, peptic ulcer, diabetes mellitus, and hepatic disease. The effect of sinonasal symptoms was neither subsumed nor overshadowed by the effects of comorbid states. Nasal, ear, sleep, and psychological domain scores were also associated with general physical, mental, and global health while adjusting for the impact of comorbidities.ConclusionSinonasal symptoms have a substantial effect on general health which is not subsumed by the presence of potentially life‐threatening concurrent comorbidities. These data may help support the importance of funding and resource allocation for conditions causing sinonasal symptoms.

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Disease burden and productivity cost of chronic rhinosinusitis patients referred to a tertiary centre in Australia

Cited by 8 publications

References 31 publications

Characterization of Chronic Sinonasal Disease Symptoms in an Urban Homeless Population

Characterization of Chronic Sinonasal Disease Symptoms in an Urban Homeless Population

A systematic review and meta-analysis of the role of doxycycline in chronic rhinosinusitis

The Impact of Sinonasal Symptoms in Relation to Potentially Life‐Threatening Comorbidities

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