Disease burden and patient needs and benefits in anogenital psoriasis: developmental specificities for person‐centred healthcare of emerging adults and adults

Silva, Neuza; Stülpnagel, Celina von; Langenbruch, Anna; Danckworth, Alexandra; Augustin, Matthias; Sommer, Rachel

doi:10.1111/jdv.16076

Cited by 11 publications

(6 citation statements)

References 41 publications

(55 reference statements)

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Section: Resultsmentioning

confidence: 99%

“…The broad spectrum of patients' treatment needs goes beyond skin clearance and includes different goals such as reducing psychological, social or physical impact, impairments due to therapy and increasing confidence in therapy. [31][32][33][34][35][36] Although some clinical trials with modern biologic agents in psoriasis offer promising long-term efficacy, 37,38 can we be sure that the impact of skin clearance on patient well-being is similar to that predicted by PASI? Changes in PASI do not necessarily translate into improved patient QoL and well-being, 39 and the relationship between disease severity (PASI) and impact on QoL-DLQI is weak.…”

Section: Expert Consensusmentioning

confidence: 99%

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Implementing well‐being in the management of psoriasis: An expert recommendation

Sommer,

Mrowietz,

Gaarn Du Jardin

et al. 2023

Acad Dermatol Venereol

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Psoriasis causes detriment in a person's physical, mental and social health which impairs their quality of life (QoL). However, the current psoriasis management may not adequately address all relevant health domains.Since the goal of healthcare is to restore or maintain health, health outcomes should include all areas of the patient's overall health. Life‐satisfaction, QoL and patient wellbeing are essential to a comprehensive approach to the disease. With the inclusion of more people‐centred policies, care of patients with psoriasis should evolve toward a holistic and integrated assessment of the disease impact, including subjective measures of wellbeing in order to encompass all aspects of health.The main objective of this expert review is to give the concept of wellbeing a place as an entity within the holistic therapeutic approach for patients with psoriasis. Identifying and defining common goals beyond the skin with the patient and testing them throughout the course of treatment will benefit and enhance treatment success. We propose a series of recommendations for application in clinical practice, providing tangible clinical guidance for implementing wellbeing in the management of psoriasis. Among the recommendations are the need to initially listen to the patient, to know their level of empowerment or what they want to achieve, their preferences in decision making, the evaluation of not only the physical but also the emotional impact of the disease (wellbeing), the definition of the aspects that can generate a cumulative deterioration of the disease throughout life, and a continuous assessment of the patient's preferences with the opinion of the expert clinician and the integration of the knowledge of external clinical evidence.

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Section: Resultsmentioning

confidence: 99%

Section: Expert Consensusmentioning

confidence: 99%

Implementing well‐being in the management of psoriasis: An expert recommendation

Sommer,

Mrowietz,

Gaarn Du Jardin

et al. 2023

Acad Dermatol Venereol

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“…Psoriasis has been reported to be associated with increased hyperlipidemia, hypertension, coronary artery disease (CAD), diabetes (type II), and obesity [ 3 ] as well as the increased risks of stroke and myocardial infarction [ 4 , 5 ]. Moreover, psoriasis is associated with anxiety, isolation, and mental disorders (e.g., depression), and it reduces socialization for patients and prevents them from having close and intimate relationships [ 6 – 8 ].…”

Section: Introductionmentioning

confidence: 99%

Application of Genetic Algorithm-Based Support Vector Machine in Identification of Gene Expression Signatures for Psoriasis Classification: A Hybrid Model

Tapak

Afshar

Afrasiabi

et al. 2021

BioMed Research International

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Background. Psoriasis is a chronic autoimmune disease impairing significantly the quality of life of the patient. The diagnosis of the disease is done via a visual inspection of the lesional skin by dermatologists. Classification of psoriasis using gene expression is an important issue for the early and effective treatment of the disease. Therefore, gene expression data and selection of suitable gene signatures are effective sources of information. Methods. We aimed to develop a hybrid classifier for the diagnosis of psoriasis based on two machine learning models of the genetic algorithm and support vector machine (SVM). The method also conducts gene signature selection. A publically available gene expression dataset was used to test the model. Results. A number of 181 probe sets were selected among the original 54,675 probes using the hybrid model with a prediction accuracy of 100% over the test set. A number of 10 hub genes were identified using the protein-protein interaction network. Nine out of 10 identified genes were found in significant modules. Conclusions. The results showed that the genetic algorithm improved the SVM classifier performance significantly implying the ability of the proposed model in terms of detecting relevant gene expression signatures as the best features.

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“…Patients often have an impaired quality of life and reduced happiness [ 8 , 9 ]. Individuals with psoriasis tend to avoid or reduce physical activities and often withdraw themselves from social activities [ 10 , 11 ] and intimate contact [ 12 , 13 ]. These social impairments are broadly individual for each patient and associated with various comorbidities [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Always Online? Internet Addiction and Social Impairment in Psoriasis across Germany

Schielein

Tizek

Schuster

et al. 2020

JCM

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With the World Health Organization (WHO) demanding further investigation of the social impairment and psychosocial burden of psoriasis, a first study identified a high prevalence of Internet addiction. The aim of this study was to assess social impairment and estimate the occurrence of Internet addiction along with depression, cigarette smoking, and alcohol dependency in individuals with psoriasis recruited online in a people-centered care approach. A cross-sectional online survey was carried out across Germany between March 2019 and June 2019. The questionnaire contained information on social impairment, smoking habits, as well as validated questionnaires on Internet addiction, depression, and alcohol dependency. Overall, 460 individuals (62.4% female; mean age: 45.9 ± 13.7 years) with psoriasis were included. Of those, 406 (88.3%) stated to be at least rarely socially impaired. The positive screening rate for Internet addiction was 8.5%. Furthermore, 40.0% had positive screenings for depression, 17.1% for alcohol dependency, and 32.6% for daily smoking. Positive screenings for Internet addiction and alcohol dependency were substantially more frequent in individuals with psoriasis than in the German general population. In order to meet the demands of the WHO, Internet addiction could be considered as a potential comorbidity in psoriasis and a focus on people-centered care is advisable for further research.

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Disease burden and patient needs and benefits in anogenital psoriasis: developmental specificities for person‐centred healthcare of emerging adults and adults

Cited by 11 publications

References 41 publications

Implementing well‐being in the management of psoriasis: An expert recommendation

Implementing well‐being in the management of psoriasis: An expert recommendation

Application of Genetic Algorithm-Based Support Vector Machine in Identification of Gene Expression Signatures for Psoriasis Classification: A Hybrid Model

Always Online? Internet Addiction and Social Impairment in Psoriasis across Germany

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