Disease burden and economic impact of diagnosed non‐alcoholic steatohepatitis in five European countries in 2018: A cost‐of‐illness analysis

Schattenberg, Jörn M.; Lazarus, Jeffrey V.; Newsome, Philip N.; Serfaty, Lawrence; Aghemo, Alessio; Augustín, Salvador; Tsochatzis, Emmanuel; Lédinghen, Victor de; Bugianesi, Elisabetta; Romero–Gómez, Manuel; Bantel, Heike; Ryder, Stephen; Boursier, Jérôme; Leroy, Vincent; Crespo, Javier; Castéra, Laurent; Floros, Lefteris; Atella, Vincenzo; Mestre-Ferrandiz, J.; Elliott, Rachel; Kautz, Achim; Morgan, Alice; Hartmanis, Sally; Vasudevan, S.; Pezzullo, Lynne; Trylesinski, Aldo; Cure, S.; Higgins, Victoria; Ratziu, Vlad

doi:10.1111/liv.14825

Cited by 87 publications

(102 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The current evidence supports the notion that NAFLD is a multisystem disease, 3 with dramatic consequences not only from the clinical point of view but also from the economic point of view. 35 In this regard, recently, Schattenberg et al clearly documented a dramatic economic impact of nonalcoholic steatohepatitis (NASH) in adults living in five European countries, namely, France, Germany, Italy, Spain and the United Kingdom. 35 Hence, earlier diagnosis and care of NAFLD and its consequences may contribute to reduce future healthcare impact and costs.…”

Section: K E Y Me Ssag E Smentioning

confidence: 99%

“…35 In this regard, recently, Schattenberg et al clearly documented a dramatic economic impact of nonalcoholic steatohepatitis (NASH) in adults living in five European countries, namely, France, Germany, Italy, Spain and the United Kingdom. 35 Hence, earlier diagnosis and care of NAFLD and its consequences may contribute to reduce future healthcare impact and costs. In doing this, a 'liver-centric' approach to NAFLD is no longer sufficient.…”

Section: K E Y Me Ssag E Smentioning

confidence: 99%

See 1 more Smart Citation

A call to action for fatty liver disease

Mantovani

Valenti

2021

Liver International

View full text Add to dashboard Cite

Section: K E Y Me Ssag E Smentioning

confidence: 99%

Section: K E Y Me Ssag E Smentioning

confidence: 99%

A call to action for fatty liver disease

Mantovani

Valenti

2021

Liver International

View full text Add to dashboard Cite

“…The prevalence and the disease burden of non‐alcoholic fatty liver disease (NAFLD) is increasing globally 1 . The asymptomatic nature of the disease and the lack of approved pharmacotherapy has led to an under‐recognition of NAFLD, even in high‐risk patient populations 2 .…”

Section: Introductionmentioning

confidence: 99%

“…The prevalence and the disease burden of non‐alcoholic fatty liver disease (NAFLD) is increasing globally. 1 The asymptomatic nature of the disease and the lack of approved pharmacotherapy has led to an under‐recognition of NAFLD, even in high‐risk patient populations. 2 NAFLD constitutes a progressive disease spectrum encompassing non‐inflammatory steatosis (non‐alcoholic fatty liver, NAFL), hepatitis (non‐alcoholic steatohepatitis, NASH) and end‐stage liver disease with associated complications.…”

Section: Introductionmentioning

confidence: 99%

Impact of thyroid disorders on the incidence of non‐alcoholic fatty liver disease in Germany

Labenz

Kostev²,

Armandi

et al. 2021

UEG Journal

Self Cite

View full text Add to dashboard Cite

Background Studies investigating a potential association between hypothyroidism and non‐alcoholic fatty liver disease (NAFLD) showed conflicting results and large‐scale population‐based data from Germany on this topic are currently missing. Objective It was the aim of this analysis to investigate the impact of thyroid gland disorders on the prevalence of NAFLD in Germany. Methods In this case‐control study, using the German disease Analyzer database (IQVIA), NAFLD patients were matched to patients without NAFLD by age, sex, index year, treating physician, diabetes mellitus type II, and obesity. The main outcome of the study was an association between thyroid gland disorders (hypothyroidism, hyperthyroidism and autoimmune thyroiditis) and incident NAFLD and was evaluated using logistic regression analyses. Results 57,483 patients with NAFLD were matched to 57,483 patients without liver disease. Mean age of the cohort was 60.3 years (±14.1) and 52.3% were men. In regression analyses, hypothyroidism (OR 1.17, 95% CI 1.10 ‐ 1.24, p < 0.001) as well as autoimmune thyroiditis (OR 1.53, 95% CI 1.35–1.73, p < 0.001) were associated with a higher risk of NAFLD. In contrast, hyperthyroidism was associated with a lower risk of NAFLD (OR 0.85, 95% CI 0.77–0.94, p < 0.001). The effect of hypothyroidism on the prevalence of NAFLD remained significant across men (OR 1.31, 95% CI 1.15–1.48) as well as women (OR 1.12, 95% CI 1.05–1.21). Conclusion Hypothyroidism seems to be a risk factor for incident NAFLD.

show abstract

“…1 Non-alcoholic fatty liver disease (NAFLD) is a potentially serious liver condition that affects close to 1 in 4 adults globally, 2,3 causing substantial impairment to health-related quality of life 4 and significant healthcare costs and economic loss. 5 Despite the scale of the challenge, NAFLD remains largely unknown outside the field of hepatology and public health response have been weak and fragmented. 6…”

Section: Introductionmentioning

confidence: 99%

A Sustainable Development Goal framework to guide multisectoral action on NAFLD through a societal approach

Lazarus

Mark²,

Colombo

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent condition that requires a comprehensive and coordinated response across sectors and disciplines. In the absence of a multisectoral framework, we developed a NAFLD Sustainable Development Goals (SDG) framework to converge thinking about the design and delivery of NAFLD public health responses. A multidisciplinary group identified SDG targets and indicators for inclusion in the NAFLD SDG framework through a two stage process. Firstly, a core team of three researchers independently reviewed the 169 SDG targets and 231 unique indicators proposed by the Inter Agency and Expert Group on SDG to select a shortlist. Over two Delphi rounds, a multidisciplinary group of 12 experts selected which of the shortlisted targets and indicators to include in the NAFLD SDG framework. Respondents also provided written feedback on their selection. Targets and indicators with 75% or greater agreement were included in the final NAFLD SDG framework. The final framework comprises 16 targets, representing 9% of all SDG targets and 62% (16/26) of the shortlisted targets, and seven indicators, accounting for 50% (7/14) of the shortlisted indicators and 3% of all SDG indicators. The selected targets and indicators cover a broad range of factors, from health, food and nutrition to education, the economy and the built environment. Addressing the challenge of NAFLD will require reenvisioning the liver health landscape, with a greater focus on joined-up systems thinking and action. The NAFLD SDG framework can help guide this process, including by outlining the key stakeholders with whom the liver health community needs to engage.

show abstract

Disease burden and economic impact of diagnosed non‐alcoholic steatohepatitis in five European countries in 2018: A cost‐of‐illness analysis

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 87 publications

References 43 publications

A call to action for fatty liver disease

A call to action for fatty liver disease

Impact of thyroid disorders on the incidence of non‐alcoholic fatty liver disease in Germany

A Sustainable Development Goal framework to guide multisectoral action on NAFLD through a societal approach

Contact Info

Product

Resources

About