Disease-Associated Risk Variants in <i>ANRIL</i> Are Associated with Tumor-Infiltrating Lymphocyte Presence in Primary Melanomas in the Population-Based GEM Study

Davari, Danielle R.; Orlow, Irene; Kanetsky, Peter A.; Luo, Li; Edmiston, Sharon N.; Conway, Kathleen; Parrish, Eloise; Hao, Honglin; Busam, Klaus J.; Sharma, Ajay; Kricker, Anne; Cust, Anne E.; Anton‐Culver, Hoda; Gruber, Stephen B.; Gallagher, Richard P.; Zanetti, Roberto; Rosso, Stefano; Sacchetto, Lidia; Dwyer, Terence; Ollila, David W.; Begg, Colin B.; Berwick, Marianne; Thomas, Nancy E.

doi:10.1158/1055-9965.epi-21-0686

Cited by 2 publications

(2 citation statements)

References 58 publications

(69 reference statements)

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“…147,148 GWASs have reported that genetic variation at ANRIL is associated with an increased risk of melanoma. 149 In one study, Maccioni et al 150 reported select variants showing a statistically significant association with the risk of melanoma, including the rs3088440 (3′ UTR CDKN2A) and variant T-allele of the tagging rs2811710 variant. In another study, also on melanoma, upregulation of ANRIL correlated with downregulation of INK4A and INK4B indicating that ANRIL exerts a probable promelanomagenesis effect via regulation of the gene locus encoding for tumor suppressors INK4A and INK4B.…”

Section: Tert †mentioning

confidence: 99%

“…GWASs have reported that genetic variation at ANRIL is associated with an increased risk of melanoma 149 . In one study, Maccioni et al 150 reported select variants showing a statistically significant association with the risk of melanoma, including the rs3088440 (3′ UTR CDKN2A ) and variant T-allele of the tagging rs2811710 variant.…”

Section: Genes Located Around Chromosome 9p21mentioning

confidence: 99%

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Melanoma and Glioblastoma—Not a Serendipitous Association

Mahalingam

2023

Advances in Anatomic Pathology

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Recently, we came across a patient with malignant melanoma and primary glioblastoma. Given this, we parsed the literature to ascertain the relationship, if any, between these 2 malignancies. We begin with a brief overview of melanoma and glioma in isolation followed by a chronologic overview of case reports and epidemiologic studies documenting both neoplasms. This is followed by studies detailing genetic abnormalities common to both malignancies with a view to identifying unifying genetic targets for therapeutic strategies as well as to explore the possibility of a putative association and an inherited cancer susceptibility trait. From a scientific perspective, we believe we have provided evidence favoring an association between melanoma and glioma. Future studies that include documentation of additional cases, as well as a detailed molecular analyses, will lend credence to our hypothesis that the co-occurrence of these 2 conditions is likely not serendipitous.

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Section: Tert †mentioning

confidence: 99%

Section: Genes Located Around Chromosome 9p21mentioning

confidence: 99%

Melanoma and Glioblastoma—Not a Serendipitous Association

Mahalingam

2023

Advances in Anatomic Pathology

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The Long Non-Coding RNA ANRIL in Cancers

Sanchez,

Lhuillier,

Grosjean

et al. 2023

Cancers

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ANRIL (Antisense Noncoding RNA in the INK4 Locus), a long non-coding RNA encoded in the human chromosome 9p21 region, is a critical factor for regulating gene expression by interacting with multiple proteins and miRNAs. It has been found to play important roles in various cellular processes, including cell cycle control and proliferation. Dysregulation of ANRIL has been associated with several diseases like cancers and cardiovascular diseases, for instance. Understanding the oncogenic role of ANRIL and its potential as a diagnostic and prognostic biomarker in cancer is crucial. This review provides insights into the regulatory mechanisms and oncogenic significance of the 9p21 locus and ANRIL in cancer.

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Disease-Associated Risk Variants in ANRIL Are Associated with Tumor-Infiltrating Lymphocyte Presence in Primary Melanomas in the Population-Based GEM Study

Abstract: Disclosure of Potential Conflicts of Interest: K Busam has received minor royalties from editing a textbook with Elsevier. SB Gruber is the Co-Founder of Brogent International LLC.

Cited by 2 publications

References 58 publications

Melanoma and Glioblastoma—Not a Serendipitous Association

Melanoma and Glioblastoma—Not a Serendipitous Association

The Long Non-Coding RNA ANRIL in Cancers

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