Disease Animal Models for Cancer Research

Complications and comorbidities associated with antineoplastic chemotherapy: Rethinking drug design and delivery for anticancer therapy

“…Obviously, complementary to clinical research, it is pragmatically impossible to ask for perfect animal models for complication/comorbidity studies. However, several principles should be taken into careful consideration for the design of animal models in the field of chemotherapy-induced complications 377 , 379 . First, the models must be grounded by a clear definition of human disease or condition being modeled which is a prerequisite for any useful animal model.…”