Disease and Economic Burden of Hospitalizations Attributable to Diabetes Mellitus and Its Complications: A Nationwide Study in Brazil

Rosa, Michelle Quarti Machado da; Rosa, Roger dos Santos; Correia, Marcelo; Araújo, Denizar Vianna; Bahia, Luciana; Toscano, Cristiana M.

doi:10.3390/ijerph15020294

Cited by 35 publications

(20 citation statements)

References 30 publications

(32 reference statements)

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“…2013). Second, consistent with a recent survey of diabetes hospitalizations in Brazil (Rosa et al. 2018), over half of the cases (54%) were hospital admissions due to unspecified diabetes, and another 6.4% were for other specified diabetes.…”

Section: Discussionsupporting

confidence: 82%

Association between Heat Exposure and Hospitalization for Diabetes in Brazil during 2000–2015: A Nationwide Case-Crossover Study

Zhao

Coelho

et al. 2019

Environ Health Perspect

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Background:Exposure to excessive heat, which will continue to increase with climate change, is associated with increased morbidity due to a range of noncommunicable diseases (NCDs). Whether this is true for diabetes is unknown.Objectives:We aimed to quantify the relationship between heat exposure and risk of hospitalization due to diabetes in Brazil.Methods:Data on hospitalizations and weather conditions were collected from 1,814 cities during the hot seasons from 2000 to 2015. A time-stratified case-crossover design was used to quantify the association between hospitalization for diabetes and heat exposure. Region-specific odds ratios (ORs) were used to calculate the attributable fractions (AFs).Results:A total of 553,351 hospitalizations associated with diabetes were recorded during 2000–2015. Every 5°C increase in daily mean temperature was associated with 6% [OR=1.06; 95% confidence interval (CI): 1.04, 1.07] increase in hospitalization due to diabetes with lag 0–3 d. The association was greatest (OR=1.18; 95% CI: 1.13, 1.23) in those ≥80y of age, but did not vary by sex, and was generally consistent by region and type of diabetes. Assuming a causal association, we estimated that 7.3% (95% CI: 3.5, 10.9) of all hospitalizations due to diabetes in the hot season could be attributed to heat exposure during the study period.Discussion:Short-term heat exposure may increase the burden of diabetes-related hospitalization, especially among the very elderly. As global temperatures continue to rise, this burden is likely to increase. https://doi.org/10.1289/EHP5688

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Section: Discussionsupporting

confidence: 82%

Association between Heat Exposure and Hospitalization for Diabetes in Brazil during 2000–2015: A Nationwide Case-Crossover Study

Zhao

Coelho

et al. 2019

Environ Health Perspect

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“…However, it mainly covers the public health system which accounts for about 70% of the total admissions and it is constantly changing (Medeiros et al, 2005; Melione and Jorge, 2008; Coelho et al, 2016; Machado et al, 2016a). Although it was created with an administrative purpose, it has been frequently used to monitor population health states and observational studies of adverse drug events (Martins et al, 2018) and health care costs (Quarti Machado Rosa et al, 2018).…”

Section: Databases Used In Health Outcomes/policy Research In Brazilmentioning

confidence: 99%

Administrative Data Linkage in Brazil: Potentials for Health Technology Assessment

et al. 2019

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Health technology assessment (HTA) is the systematic evaluation of the properties and impacts of health technologies and interventions. In this article, we presented a discussion of HTA and its evolution in Brazil, as well as a description of secondary data sources available in Brazil with potential applications to generate evidence for HTA and policy decisions. Furthermore, we highlighted record linkage, ongoing record linkage initiatives in Brazil, and the main linkage tools developed and/or used in Brazilian data. Finally, we discussed the challenges and opportunities of using secondary data for research in the Brazilian context. In conclusion, we emphasized the availability of high quality data and an open, modern attitude toward the use of data for research and policy. This is supported by a rigorous but enabling legal framework that will allow the conduct of large-scale observational studies to evaluate clinical, economical, and social impacts of health technologies and social policies.

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“…The DM leads to a diminution of life quality due to both acute and chronic consequences, reduces life expectancy and leads to higher mortality [3][4][5][6]. DM caused 4.0 million deaths in 2017.…”

Section: Introductionmentioning

confidence: 99%

An Exploratory Research of 18 Years on the Economic Burden of Diabetes for the Romanian National Health Insurance System

Morgovan

Cosma

Văleanu

et al. 2020

IJERPH

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The prevalence of diabetes mellitus (DM) rises constantly each year worldwide. Because of that, the funds allocated for the DM treatment have increased over time. Regarding the number of DM cases, Romania is among the top ten countries in Europe. Based on the National Diabetes Programme (NDP), antidiabetic drugs and other expenditures (Self-monitoring blood glucose (SMBG) test, HbA1c, insulin pumps/insulin pumps supplies) are free of charge. This programme has undergone many changes in drugs supply, in the last two decades: re-organizing the NDP, authorization of new molecules with high prices (e.g., SGLT-2 inhibitors, etc.) or new devices (e.g., insulin pumps, etc.) The main purpose of this study is to identify and analyse the impact of the DM costs on the Romanian health budget and to highlight the evolution of these costs. A retrospective longitudinal research on the official data regarding the DM costs from 2000 to 2017 was performed. The DM funds (DMF) were adjusted with the inflation rate. In this period, the average share of DMF in the total funds allocated for health programmes was 21.3 ± 3.4%, and DMF average growth rate was 25.4% (r = 0.488, p = 0.047). On the other hand, the DMF increased more than 14 times, in spite of the patients’ number having increased only about 2.5 times. Referring to the structure of DMF, the mean value of the antidiabetic drugs cost was of 96,045 ± 67,889 thousand EUR while for other expenditures it was of 11,530 ± 7922 thousand EUR (r = 0.945, p < 0.001). Between 2008 and 2017, the total DMF was 181,252 ± 74,278 thousand EUR/year. Moreover, the average patients’ number was 667,384 ± 94,938 (r = 0.73, p = 0.016), and the cost of treatment was 215 ± 36 EUR/patient/year. Even if the cost is rising, the correct and optimal treatment is a main condition for the diabetic patient’s health and for the prevention of its complications, which have multiple socio-economic repercussions.

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Disease and Economic Burden of Hospitalizations Attributable to Diabetes Mellitus and Its Complications: A Nationwide Study in Brazil

Cited by 35 publications

References 30 publications

Association between Heat Exposure and Hospitalization for Diabetes in Brazil during 2000–2015: A Nationwide Case-Crossover Study

Association between Heat Exposure and Hospitalization for Diabetes in Brazil during 2000–2015: A Nationwide Case-Crossover Study

Administrative Data Linkage in Brazil: Potentials for Health Technology Assessment

An Exploratory Research of 18 Years on the Economic Burden of Diabetes for the Romanian National Health Insurance System

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