DISCUSSION PAPER: ARE PERIPHERAL AND <i>IN SITU</i> TUMOR IMMUNITY RELATED?*

Haskill, J. S.; Yamamura, Yuichi; Radov, L. A.; Parthenais, Elaine

doi:10.1111/j.1749-6632.1976.tb41662.x

Cited by 15 publications

(8 citation statements)

References 7 publications

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“…2b), the incidence of metastases fell to 14% 25 days after tumour excision at a time when immunity returned to the blood stream. Such regression need not have been immunologically mediated, but the 1699 tumour is known to regress following s.c. injection into the belly [22] and the histological appearance of the granulomatous lesions in our study arc reminiscent of those reported following intralesional BCG [23] and of spontaneous regression of rat sarcomas and a case of human melanoma [Proctor, personal observations]. The regression, if it was immunological in nature, is para doxical, since there was an absence of immunity in the blood stream of the same organ during the same time period.…”

Section: Discussionsupporting

confidence: 84%

“…These findings raise the question as to whether an immune response can be redirected from one site to another or 'finessed' by an antigenic challenge, and certainly support the contention that the status of immunity varies from one anatomical site (e.g. organ or tissue) to another [10,17] including in situ' within the tumour mass [22].…”

Section: Discussionmentioning

confidence: 66%

“…After tumour excision in the present ex periment, histiocytic cells were identified in the granulo matous and presumptively regressing metastases [Proc tor, personal observation]. Furthermore, monocytes from within the tumour have been observed to be cytostatic to 1699 cells in tissue culture [22].…”

Section: Discussionmentioning

confidence: 91%

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Variations in the Level of Haematogenous Antitumour Immunity during Progressive Tumour Growth and Spontaneous Blood-Borne Metastatic Spread

Proctor¹,

Mastromatteo²,

Antos³

et al. 1979

Oncology

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Inbred DBA₂ mice bearing the syngeneic 1699 mammary tumour in the hind limb were challenged intravenously with ¹²⁵IUdR-labelled single 1699 cell suspensions, and the amount of radioactivity in the lungs compared 20–24 h later with that in the lungs of normal mice or in those of mice bearing the antigenically unrelated syngeneic SaD₂ tumour. An immunologically specific decrease in radioactivity was evident at variable periods of time after tumour induction, depending on the number of cells used to induce the leg tumours, but fell below that in normal mice as the leg tumours progressed beyond a weight of approximately 1 g. As assessed by microscopic scanning of serial histological sections of the same lungs the incidence of spontaneous metastases rose to between 80 and 100% immediately the amount of cell loss from the lungs of the tumour-bearing mice reached that of the normal controls. This extremely rapid series of events does not allow a definitive conclusion as to whether immunity failed and led to metastatic spread or vice versa, but does underline the strong association of immunity with the blood-borne dissemination of tumour cells in this tumour system. Following excision of tumours, in no instance was immunity detected 14 days later, and in a single experiment did not reach detectable limits until 25 days after excision, at a time when the lung metastases were observed mostly to have regressed spontaneously.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 66%

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Variations in the Level of Haematogenous Antitumour Immunity during Progressive Tumour Growth and Spontaneous Blood-Borne Metastatic Spread

Proctor¹,

Mastromatteo²,

Antos³

et al. 1979

Oncology

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“…In a syngeneic murine mammary adenocarcinoma T1699 growing in DBA/2J female mice, we have pre viously demonstrated that in situ effector cells [15,16) are specifically armed monocytes [14][15][16] and also that the serum from tumor-bearing hosts contained a non antibody factor(s) which could transfer specific anti tumor immunity to normal recipients. Such host immu nity provided by passive transfer of serum depended on some host cellular components [30].…”

Section: Introductionmentioning

confidence: 99%

Immunological Responses to a Murine Mammary Adenocarcinoma

Yamamura¹

1980

Oncology

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Serum from DBA/2J mice bearing a syngeneic T1699 mammary adenocarcinoma contains not only a specific antitumor antibody but also another factor(s) which arm normal monocytes in vitro and transform them into specific killer cells. Arming of normal monocytes by the factor(s) was inhibited by cytochalasin B and dactinomycin but not by mitomycin C. The ADCC activity of monocytes was at least partially resistant to the action of dactinomycin but cytotoxicity of armed effectors was totally blocked by the same drug. Effective cytolysis by armed monocytes required at least 5–6 h of continuous contact between the target and effector cells; and cytotoxicity could be reversed by cytochalasin B during this period.

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“…Phagocytic cells were identified by their ability to ingest either latex particles or EA RFC, assayed according to the method of Haskill et al [12]. In every instance, more than 70% of these cells were phagocytic, and more than 90 % were esterase-positive.…”

Section: Characterization Of Cells In Different Subpopulationsmentioning

confidence: 99%

Role of adherent T cells and of B cells in the immune response to purified protein derivative of tuberculin

et al. 1979

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The role of monocytes, B cells, and adherent and nonadherent T cells in the response of purified protein derivative of tuberculin (PPD) as measured by [3H]thymidine uptake in vitro has been explored. The response to PPD was found to be highly dependent on monocytes, to approximately the same extent as previously found for the responses to concanavalin A (Con A) and phytohemagglutinin. The response to PPD was also found to be highly dependent on a population of adherent T cells different from the adherent T cell population involved in the response to Con A. In the case of PPD, the effect was additive, as opposed to the potentiating effect seen for Con A. Further, the adherent T cells involved in the response to PPD were much more sensitive to hypotonic shock than those in the response to Con A. B cells were also found to be important in the response to PPD, although only to a slight extent.

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DISCUSSION PAPER: ARE PERIPHERAL AND IN SITU TUMOR IMMUNITY RELATED?*

Cited by 15 publications

References 7 publications

Variations in the Level of Haematogenous Antitumour Immunity during Progressive Tumour Growth and Spontaneous Blood-Borne Metastatic Spread

Variations in the Level of Haematogenous Antitumour Immunity during Progressive Tumour Growth and Spontaneous Blood-Borne Metastatic Spread

Immunological Responses to a Murine Mammary Adenocarcinoma

Role of adherent T cells and of B cells in the immune response to purified protein derivative of tuberculin

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