Pearl River Mouth Basin (PRMB), the main studied area in this study, is located in the northern South China Sea (SCS) margin. Heat flow measurements indicate that the PRMB is a typical “hot basin” characterized by a high background heat flow. However, the tectono-thermal evolution and the mechanism are still controversial and have not been studied effectively due to the different input parameters used in the tectono-thermal modeling, limited dataset and limited studied area of the basin. This study employs tectono-thermal modeling with a multi-stage finite stretching model, constrained by extensive well data, to systematically analyze the tectono-thermal evolution from proximal to hyperextended domains of the PRMB since the onset of rifting. Compared with previous studies, the study area has been expanded to cover both proximal and hyperextended regions of the northern SCS margin, providing a more comprehensive understanding of its tectonic-thermal history. Numerous wells and seismic data covering the entire basin were utilized, along with appropriate input parameters, to address gaps in prior studies and enhance result accuracy. Findings indicate that the PRMB underwent two heating phases primarily due to lithospheric extension thinning during rifting. By the end of rifting, the Northern Depression Zone and Kaiping Sag reached peak heat flow, while the Panyu Lower Uplift and Baiyun Sag saw their highest heat flow since initial rifting. During the post-rift stage, the PRMB experienced thermal decay, but a significant reheating event occurred from 23.03 to 13.82 Ma, likely due to northward lower crustal flow from the Baiyun Sag. By the end of 13.82 Ma, the Panyu Lower Uplift and the Baiyun Sag reached their peak heat flow and the heat flow generally increased 1-3 mW/m
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in the other study areas during this stage. At 5.33 Ma, the basin's thermal decay slowed, and localized heating events linked to magmatic activities in the southern Dongsha Uplift were observed. In general, the proximal domain of the northern SCS margin reached reached peak heat flow by the end of rifting, while the hyperextended domain reached peak heat flow by the end of 13.82 Ma. Heat flow in the hyperextended domain is generally higher than that in the proximal domain, for the thinner crustal thickness of the hyperextended domain caused by intensively multiple lithospheric detachment-extensional thinning processes. During the rifting stage, the lithospheric extensional thinning process is the most important factor influencing the tectono-thermal evolution of the northern SCS margin, while the lower crustal flow and magmatism are the main important factors during the post-rift stage.