“…Earlier publications have described methods for berberine determination in biological samples utilizing HPLC-UV [3][4][5][6][7][8][9][10], HPLC-fluorimetry [11], field desorption-mass spectrometry [12] and GC-chemical ionization-mass spectrometry [13]. Recently, Tong and Yan [14] have developed a method to determine berberine and palmatine in rat plasma by LC-MS/MS in the selected ion-monitoring (SIM) mode.…”