Discussion of Pathogen and Potential Therapeutic Strategy for Triple Negative Breast Cancer Based on a Rare Case Study

Abstract

Triple Negative Breast Cancer (TNBC) accounts for 10-22% of all breast cancer patients. Here we report a rare case of TNBC patient with metastasis to opposite chest organs, left abdomen the rectus muscle, eventually to brain. According to course of disease and gene expression profile in this case, we discuss the pathogen and potential therapeutic strategy for TNBC: DNA mythelation may be the main cause for the negative expression and mutations of breast cancer biomarkers. Hormone therapy is dangerous for TNBC patients. Immunomodulators and antineovascularization may bring the breakthrough for increasing survival rate of TNBC patients.

Dexamethasone Restores the Neovascularization of Spine Cord in Experimental Autoimmune Encephalomyelitis (EAE) Rodent Models

“…Hormone treatments showed increased expression of HIFs in human metastatic cancer cell lines (data not published), while hypoxia increased mobility of actin positive cells as well as pericytes [4]. Hormone therapy is dangerous for patients with brain metastatic Triple Negative Breast Cancer [5]. Taken together, the mechanism of neovascularization in center nerve system induced by Dexamethasone in this study may be that hormone stabilized the microenvironment of injured area of CNS, protected or activated the transformed pericytes from inflammation cells.…”