Discussion of an individual joint

Abstract

the massive outcome trial which that group is now mounting and said: "Until they report we can either sit back or offer to join them and speed the trial on its way." As readers of my review will know, in a lethal condition such as acute myocardial infarction I place more reliance on the factual end point of death than on opinions as to whether any trial regimen can prevent the "intermediate coronary syndrome" from evolving into "transmural myocardial infarction." In the trial of Dr Telford and Dr Wilson two regimens (heparin and atenolol) each with its own placebo were being tested. The total deaths from entry to eight weeks were: placebo heparin and placebo atenololtwo; placebo heparin and atenolol-three; heparin and placebo atenolol-nought; and heparin and atenolol-nought. To conclude that: "The medical management of the intermediate coronary syndrome should include intravenous heparin" still seems to me to be raising statistical significance above common sense.

Fighting Thatcher with Comedy: What to Do When There Is No Alternative

“…Discussing the bête noire of alternative comedians, Bernard Manning, Griffiths explained the comedian's popularity as rooted in his closeness to his audience: "he loves those people anyway not just because they laughed but because he knows they're going home to two-up two-downs." 181 For Griffiths, Manning's success needs to be understood in these terms. "He lives there, red brick and shit, and he cares."…”