Discussion Addendum for: Rh(I)‐Catalyzed Allenic Pauson–Khand Reaction

Abstract

The intramolecular Rh(I)‐catalyzed allenic Pauson–Khand reaction (APKR) is a powerful synthetic method for constructing ring‐fused cyclopentenones. This discussion addendum informs on a few recent advances made regarding expansion of the scope of the APKR and its application to target‐oriented synthesis. In this chapter, the authors divided addendum into the following topics: Asymmetric Allenic Pauson–Khand Reaction; Transfer of Allene Axial Chirality in APKR; Rh(I)‐Catalyzed APKR Double Bond Selectivity, Mechanism, and Reaction Optimization; and APKR Approach to Natural Products and Other Bioactive Compounds. In summary, the APKR has played an important role in target‐oriented organic synthesis. Amongst different metals including Fe, Mo, and Co being used as the catalyst in APKR, Rh is the most prominent in the recent advances in this area. For additional insight and information on the APKR several reviews have been published.