Discriminatory value of carotid artery elasticity changes for the evaluation of thyroid dysfunction in patients with hashimoto's thyroiditis

Feng, Xiaolei; Zhao, Linlin; Jiang, Jue; Ma, Wen-Qi; Xue, Shang; Zhou, Qi; Zhao, Hongli; Yu, Shanshan; Qi, Yanhua

doi:10.1002/jcu.22328

Cited by 5 publications

(5 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Participants with TSH levels lower than 0.03 mIU/l presented higher IMT values compared to participants with higher TSH levels (25). Two other recent Chinese studies have also found an inverse relationship between low TSH levels and high IMT values in subjects with subclinical hyperthyroidism (26,27). In our study, the only association we found was between IMT with SCH, but never with subclinical hyperthyroidism.…”

Section: A C C E P T E D Accepted Manuscriptcontrasting

confidence: 49%

Subclinical hypothyroidism is associated with higher carotid intima-media thickness in cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Miranda

Bittencourt

Pereira

et al. 2016

Nutrition, Metabolism and Cardiovascular Diseases

View full text Add to dashboard Cite

Section: A C C E P T E D Accepted Manuscriptcontrasting

confidence: 49%

Subclinical hypothyroidism is associated with higher carotid intima-media thickness in cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Miranda

Bittencourt

Pereira

et al. 2016

Nutrition, Metabolism and Cardiovascular Diseases

View full text Add to dashboard Cite

“…Further studies confirmed the increase in aortic stiffness, measured either with brachial-ankle or heart-femoral PWV [ 21 , 22 ] and observed a decrease in stiffness after l-thyroxine replacement [ 23 , 24 ]. The increase in stiffness was confirmed by other methodologies, as the evaluation of β-stiffness index in the carotid artery [ 25 , 26 , 27 ], or the augmentation index [ 28 , 29 ], while the evaluation of global aortic distensibility gave contrasting results [ 30 , 31 ]. Considering the response to treatment, the augmentation index tended to reduce with levothyroxine replacement therapy [ 32 ].…”

Section: Resultsmentioning

confidence: 88%

Arterial Stiffness in Thyroid and Parathyroid Disease: A Review of Clinical Studies

Grillo

Barbato

Antonello

et al. 2022

JCM

View full text Add to dashboard Cite

Growing evidence shows that arterial stiffness measurement provides important prognostic information and improves clinical stratification of cardiovascular risk. Thyroid and parathyroid diseases are endocrine diseases with a relevant cardiovascular burden. The objective of this review was to consider the relationship between arterial stiffness and thyroid and parathyroid diseases in human clinical studies. We performed a systematic literature review of articles published in PubMed/MEDLINE from inception to December 2021, restricted to English languages and to human adults. We selected relevant articles about the relationship between arterial stiffness and thyroid and parathyroid diseases. For each selected article, data on arterial stiffness were extracted and factors that may have an impact on arterial stiffness were identified. We considered 24 papers concerning hypothyroidism, 9 hyperthyroidism and 16 primary hyperparathyroidism and hypoparathyroidism. Most studies evidenced an increase in arterial stiffness biomarkers in hypothyroidism, hyperthyroidism and primary hyperparathyroidism, even in subclinical and mild forms, although heterogeneity of measurement methods and of study designs prevented a definitive conclusion, suggesting that the assessment of arterial stiffness may be considered in the clinical evaluation of cardiovascular risk in these diseases.

show abstract

“…Secondly, many studies might have included plaques in the measurements of IMT, especially if these were located in areas predefined for IMT measurement. Thirdly, differences among IMT measurements could be due to other determinants of the IMT thickness, such as mean cholesterol, hypertension or age (19). IMT increases linearly with age even in subjects without atherosclerotic disease, probably as a reflection of senescence-related inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…The reverse effect was observed in the deficiency of the hormones (18). On the other hand, thyroid hormones can affect vascular endothelial cells by modulating the expression of adenylyl cyclase and Ca21-ATPase, which affects the endothelium-dependent vasodilatation, contributing in vivo 34: 3127-3136 (2020) to a decrease in pulse wave velocity (PWV) (19). In the same frame, recombinant human TSH administration can acutely impair endothelium-dependent vasodilatation, possibly by inducing an inflammatory response and reducing nitric oxide (1).…”

Section: General Principlesmentioning

confidence: 99%

“…As far as hyperthyroidism is concerned, Feng et al (19) have evaluated the carotid artery wall-thickness in 180 female patients with Hashimoto thyroiditis, who were assigned to three groups on the basis of laboratory testing: i) hyperthyroidism, ii) hypothyroidism and iii) euthyroid. IMT was significantly higher in the hyperthyroidism group than in controls (p<0.05) or the other groups (p<0.05).…”

Section: Thyroid Dysfunction and Carotid Artery Atherosclerosismentioning

confidence: 99%

See 1 more Smart Citation

Thyroid Dysfunction and Atherosclerosis: A Systematic Review

Παπαδοπούλου

Bakogiannis

Skrapari

et al. 2020

In Vivo

View full text Add to dashboard Cite

Background/Aim: Thyroid dysfunction, both hypoand hyperthyroidism, has been associated with cardiovascular disease. The aim of this study was to evaluate the association between thyroid dysfunction and atherosclerosis measured mostly by carotid intima-media thickness, as well as discuss whether L-T4 replacement is able to reverse or slow down the progression of atherosclerosis. Materials and Methods: The review was conducted according the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. We performed on PubMed a literature search from May 2004 to January 2020, using the search terms 'subclinical hypothyroidism' or 'thyroid disorders' and 'carotid artery', 'carotid intima-media thickness (IMT)', 'levothyroxine', and 'atherosclerosis'. Results: Twenty-six studies were eligible and included in the analysis. Overall, the studies encompassed a total of 36.434 patients included in this review. Most studies indicated a proportional correlation between IMT and thyroid dysfunction. Levothyroxine (L-T4) replacement led to significant decrease of IMT after 1 year in most studies. Conclusion: Most studies have concluded that thyroid dysfunction is associated with arterial wall remodeling and, thus, with increased cardiovascular risk. However, the exact mechanistic background of pathological structural changes in the arterial wall is still unsettled. Large randomized controlled studies are required to definitively address the extent to which T4 replacement therapy might benefit patients with subclinical thyroid disorders.The review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. We performed on PubMed a literature search for the articles published from May 2004 until January 2020, using the 3127 This article is freely accessible online.

show abstract

Discriminatory value of carotid artery elasticity changes for the evaluation of thyroid dysfunction in patients with hashimoto's thyroiditis

Abstract: DC and PWV may be useful for the evaluation of thyroid function in HT patients. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound 44:298-304, 2016.

Cited by 5 publications

References 32 publications

Subclinical hypothyroidism is associated with higher carotid intima-media thickness in cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Subclinical hypothyroidism is associated with higher carotid intima-media thickness in cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Arterial Stiffness in Thyroid and Parathyroid Disease: A Review of Clinical Studies

Thyroid Dysfunction and Atherosclerosis: A Systematic Review

Contact Info

Product

Resources

About