“…Two stand-alone investigations provide preliminary insights into the role of training dose for the α 1 -subunit selective agonist alpidem (Sanger and Zivkovic, 1994) and the partial inverse agonist β-CCE (Rowlett et al, 1999). Numerous studies demonstrated that benzodiazepine training dose magnitude was inversely proportional to the number of sessions to discrimination criteria in rats (Bruner and Anderson, 2009; De Vry and Slangen, 1986b; Shannon and Herling, 1983; Tang and Franklin, 1991; Sanger and Zivkovic, 1994; Rowlett et al, 1999) and gerbils (Järbe and Swedberg, 1998). It is similarly well documented that lower benzodiazepine training doses are associated with a leftward shift in the dose-response curve (i.e., lower ED 50 ) when compared to higher doses of the same training drug in rats (Ator and Griffiths, 1989; De Vry and Slangen, 1986b, 1986b; Bruner and Anderson, 2009; Sannerud and Ator, 1995a, 1995b; Shannon and Herling, 1983; Tang and Franklin, 1991; Sanger and Zivkovic, 1994; Rowlett et al, 1999) and humans (Rush et al, 1995).…”