Discriminative power on mortality of a modified Sequential Organ Failure Assessment score for complete automatic computation in an operative intensive care unit

Jünger, Alexander; Engel, J.; Benson, Matthew A.; Böttger, Sebastian; Grabow, Caroline; Hartmann, Bernd; Michel, A.; Röhrig, Rainer; Marquardt, Kurt; Hempelmann, G.

doi:10.1097/00003246-200202000-00012

Cited by 35 publications

(32 citation statements)

References 10 publications

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“…The body of research on the attributes of the SOFA score shows that it has good to excellent performance to discriminate the status (dead or alive) at discharge of critically ill patients [3][4][5][6]15,[19][20][21][22][23][24], but despite this large body of evidence, only a handful of studies have formally reported on the validity of the SOFA score by using independent samples to test the accuracy and calibration of their findings [11,12,17,25,26]. By omitting a formal evaluation of the attributes of the score in independent samples, the reported properties of the SOFA score can only be generalized with caution to other groups of critically ill patients.…”

Section: Introductionmentioning

confidence: 99%

Cross-validation of a Sequential Organ Failure Assessment score–based model to predict mortality in patients with cancer admitted to the intensive care unit

Cardenas‐Turanzas

Ensor

Wakefield

et al. 2012

Journal of Critical Care

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Section: Introductionmentioning

confidence: 99%

Cross-validation of a Sequential Organ Failure Assessment score–based model to predict mortality in patients with cancer admitted to the intensive care unit

Cardenas‐Turanzas

Ensor

Wakefield

et al. 2012

Journal of Critical Care

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“…Likewise, dynamic assessment of the SOFA score is superior at predicting 28-day survival/mortality [39][40][41]. Furthermore, modifications of the SOFA score [42][43][44][45][46] have been shown to have good discrimination of development of more severe morbidity.…”

Section: Discussionmentioning

confidence: 99%

The Utility of the Sequential Organ Failure Assessment Score in Predicting Mortality in Critically Ill Obstetric Patients Admitted to a High Dependency Unit in Uganda

Kaye¹

2017

IPCB

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Background: Most maternal deaths result from severe maternal morbidity (SMM with subsequent organ/system dysfunction and organ failure. The objective was to assess the performance of Sequential Organ Failure Assessment (SOFA) score in cases of SMM admitted to the high dependency obstetric unit.Methods: Organ/system dysfunction and failure were assessed according to the maximum score for the six components (respiratory, neurological, renal, hepatic, cardiovascular and coagulation system). The total maximum SOFA score was estimated using the worst result each component on a single day. The distribution of SOFA scores was assessed for normality by using the Shapiro Wilk Test, [p=003]. The mean maximum SOFA scores for each organ/system were computed according to according to outcome (survival or death), using the Mann-Whitney test. The sensitivity, specificity, and the area under the curve (AUC) for each organ/system were evaluated. A Receiver Operator Characteristic (ROC) curve was fitted using maximum likelihood estimates for the total maximum SOFA score, in order to assess the sensitivity, specificity and discriminatory abilities of the maximum SOFA scores. Results:Of the 425 patients with SMM, 345 (81.2%, 95%CI 71.8-82.4) survived while 80 (18.8%, 95% CI: 12.9, 22.6) did not survive. All the non-survivors and 64 (18.5%) of the survivors presented with multiple organ/system dysfunction. Nonsurvivors were more likely to present with more severe and with multiple organ/ system dysfunction. The maximum total SOFA score had good discrimination in the respiratory, cardiovascular and neurological systems, but poor discrimination in the renal, hepatic and coagulatory systems. The total maximum SOFA score displayed an area under the curve (AUC) of 0.83 (95% CI: 0.56, 1.00), with a cutoff value of at least 8.0 sensitivity of 86.7%, and specificity of 90.0%. Conclusion:The total maximum SOFA score showed good predictive and discriminative abilities for maternal mortality in women with severe maternal morbidity.

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“…The SOFA score has been modified previously for surgical 21 and trauma patients 22 , as well as for children 23 In a search for a scoring model for patients with cancer, Groeger et al developed the Intensive Care Unit Cancer Mortality Model 7 , and that score was customized later to be used in patients under mechanical ventilation 25 and to evaluate the outcomes of patients with cancer after 72 hours of intensive care management 26 . The Intensive Care Unit Cancer Mortality Model score performed well, but it is complicated to calculate and not feasible for use in large administrative and clinical data sets.…”

Section: Discussionmentioning

confidence: 99%

Automating and simplifying the SOFA score in critically ill patients with cancer

Nates

Cardenas‐Turanzas

Wakefield

et al. 2010

Health Informatics J

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The aim was to demonstrate the performance of a modified version of the Sequential Organ Failure Assessment (SOFA) score to predict mortality in medical and surgical patients with cancer. We performed an electronic retrospective review of databases. We included adult patients with cancer admitted into a 53-bed ICU over 28 months. We electronically calculated a modified SOFA (mSOFA) score at admission. A majority of the patients were admitted into the surgical ICU. Of 328 nonsurvivors, 85.1 per cent were medical patients and only 14.9 per cent surgical patients. The mean admission mSOFA scores for medical and surgical patients were 4.7 +/- 3.2 and 1.7 +/- 1.9, respectively. The overall area under the curve (AUC) of the mSOFA score was 0.84. The AUCs for medical and surgical patients were 0.72 and 0.78, respectively. Our results demonstrate that electronic assessment of mSOFA score has potential in resource allocation decisions as well as in critical care outreach programs.

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Discriminative power on mortality of a modified Sequential Organ Failure Assessment score for complete automatic computation in an operative intensive care unit

Abstract: Despite a number of differences between completely automated data sampling of SOFA score values and manual evaluation, the technique used in this study seems to be suitable for prognosis of the mortality rate during a patient's stay at an operative ICU.

Cited by 35 publications

References 10 publications

Cross-validation of a Sequential Organ Failure Assessment score–based model to predict mortality in patients with cancer admitted to the intensive care unit

Cross-validation of a Sequential Organ Failure Assessment score–based model to predict mortality in patients with cancer admitted to the intensive care unit

The Utility of the Sequential Organ Failure Assessment Score in Predicting Mortality in Critically Ill Obstetric Patients Admitted to a High Dependency Unit in Uganda

Automating and simplifying the SOFA score in critically ill patients with cancer

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