Discriminative Behavior as an Index of Toxicity

Evans, Hugh L.; Daniel, Stephen A.

doi:10.1016/b978-0-12-004704-8.50013-4

Cited by 6 publications

(2 citation statements)

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“…Because drug effects on the temporal control of behavior and response tendencies can be more easily separated by the discrete-trial titration procedure, it may be preferred for study of the effects of drugs and toxicants on the temporal control of behavior [Daniel and Evans, 1985;Evans and Daniel, 19841. A more extensive discussion of the differences in estimation and production procedures was provided by Evans and Daniel [1984].…”

Section: Discussionmentioning

confidence: 99%

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Titration of duration discrimination in behavioral pharmacology and toxicology

Daniel

Evans

1990

Drug Development Research

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Daniel, S.A., and Evans, H.L.:Titration of duration discrimination in behavioral pharmacology and toxicology. Drug Dev. Res. 20:123-139, 1990. This study investigated a discrete-trial, titration duration discrimination procedure in behavioral pharmacology. Pentobarbital and d-amphetamine, measured with this procedure, selectively affected discrimination more than response tendencies. Pentobarbital also tended to affect selectively discrimination of longer durations, whereas d-amphetamine did not. Further experiments showed that 1) other algorithms for modulating stimulus duration are useful in behavioral pharmacology and toxicology, 2) threshold estimates are similar with the method of constant stimuli and the method of titration, and 3) this titration procedure permits the separate examination of drug effects upon discrimination and upon response tendencies; the fixed-interval procedure does not. Baseline variability was an important correlate of drug effects in that the endpoints with more variable baselines were also more sensitive to drugs.

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Section: Discussionmentioning

confidence: 99%

“…Measures of various behavioral functions are likely to differ in baseline variability and the variability might influence the procedure's ability to detect drug effects [Dews and Evans and Daniel, 1984, with permission of the publisher.) Wenger, 1979;Evans and Daniel, 1987;Evans, 19891.…”

Section: The Effects Of Pentobarbital On Fixed-interval (Fi) Respondingmentioning

confidence: 99%