Discriminative ability of conventional echocardiography and tissue Doppler imaging techniques for the detection of subclinical cardiotoxic effects of treatment with anthracyclines

Kapusta, Livia; Thijssen, J.M.; Groot-Loonen, Jacqueline; Druten, J.A.M. van; Daniëls, Otto

doi:10.1016/s0301-5629(01)00470-7

Cited by 26 publications

(13 citation statements)

References 37 publications

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“…Several other studies also added convergent data regarding the usefulness of DMI for detecting subclinical myocardial damage in apparently healthy survivors of childhood cancer [27,28,48]. Another small study, designed to evaluate the effects of chemotherapy given during pregnancy on fetal development and pediatric cardiac outcome, showed that doxorubicin treatment was safe for the offspring and did not result in disturbance of cardiac development or function, as assessed by both conventional and DMI indices [55].…”

Section: Advanced Echocardiographic Methodsmentioning

confidence: 94%

Detection and monitoring of cardiotoxicity—what does modern cardiology offer?

Jurcuţ

Wildiers²,

Gáname³

et al. 2008

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This review will discuss conventional and modern cardiologic approaches of assessing myocardial function. It will focus on Doppler myocardial imaging, a method which allows to sensitively measure myocardial function parameters like myocardial velocity, deformation (strain), or deformation rate (strain rate) and which has been shown to reliably detect early abnormalities in both regional and global myocardial function in an early stage. Other newer echocardiographic function estimators are based on automated border detection algorithms and ultrasonic integrated backscatter analysis. A further technique to be discussed is dobutamine stress echocardiography. The use of new biomarkers like B-type natriuretic peptide and troponin and less often used imaging techniques like magnetic resonance imaging and computed tomography will also be mentioned.

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Section: Advanced Echocardiographic Methodsmentioning

confidence: 94%

Detection and monitoring of cardiotoxicity—what does modern cardiology offer?

Jurcuţ

Wildiers²,

Gáname³

et al. 2008

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“…This parameter is considered an important and reliable early predictor for the development cardiac dysfunction in other causes of cardiac disease (Nikitin and Witte, 2004). From several small studies in adult childhood cancer survivors, it seemed to be a valuable parameter in defining diastolic (dys-) function (Kapusta et al, 2001;Brouwer et al, 2006;Tassan-Mangina et al, 2006;Galderisi et al, 2007). E/E 0 is a derivative of TVI Et and the E velocity, thereby including the end-diastolic left ventricular filling pressure in addition to myocardial velocities.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of sub-acute changes in cardiac function after cisplatin-based combination chemotherapy for testicular cancer

et al. 2009

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Long-term cardiovascular morbidity is increasingly observed in chemotherapy-treated testicular cancer survivors, but little is known of early sub-clinical changes in cardiac function. We prospectively evaluated cardiac function in testicular cancer patients by echocardiography. Systolic (Wall Motion Score Index) and diastolic (E/A-ratio and Tissue Velocity Imaging (TVI)) parameters, and serum levels of N-Terminal pro-Brain Natriuretic Peptide (NT-proBNP) were assessed before the start of chemotherapy and 1 year later. Echocardiography data were compared with an age-matched group of healthy controls. Forty-two patients treated with bleomycin, etoposide and cisplatin were evaluated (median age 27 years, range 18 -50). Systolic function and E/A-ratio did not change, whereas the median TVI decreased (12.0 vs 10.0 cm s À1 ; P ¼ 0.002). Median levels of NT-proBNP increased (5 vs 18 pmol l À1 , P ¼ 0.034). Compared with controls, TVI before the start of chemotherapy was not significantly different. In conclusion, we found that at a median of 10 months after cisplatin-based treatment for testicular cancer, TVI decreased significantly, indicating a deterioration of diastolic cardiac function. Serum levels of NT-proBNP increased. The prognostic significance of these changes for future cardiovascular morbidity is not clear.

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“…8 Our finding of transiently increased left wall thickness appears to be unique in the literature. Furthermore, we demonstrated acute reductions in early diastolic annular velocities (E ) despite preservation of systolic function with normalization post restoration of normal left ventricular appearance.…”

Section: Case Reportmentioning

confidence: 54%