The clinical significance of osteoporosis lies in the fractures that occur, and the most important fracture is hip fracture. According to the 1994 World Health Organization (WHO) criteria, the T-score is defined as: (BMD patient -BMD young normal mean )/SD young normal population, where BMD is bone mineral density and SD is the standard deviation. When the femoral neck is measured in adult women, a cutpoint value of patient BMD of 2.5 SD below the BMD young normal mean satisfies that the prevalence of osteoporosis for those aged ≥50 yrs is about 16.2%, the same as the lifetime risk of hip fragility fracture (FF) (1,2). If other sites are also considered, this cutpoint value identifies approximately 30% of postmenopausal women as having osteoporosis, which is approximately equivalent to the lifetime risk of FF at the spine, hip, or forearm. The FF prevalence of older Chinese women is slightly less than half that of Caucasians (3,4). This is the case for hip FF (5-7), radiographic vertebral FF (8), clinical vertebral FF (9-11), and many other FF sites (3,4,12,13). As compared with Caucasians, Chinese demonstrate an overall stronger skeleton property (14). For example, Walker et al. (15) reported that postmenopausal Chinese women have a higher trabecular plate-to-rod ratio and greater whole bone stiffness, translating into a greater trabecular mechanical competence.Following the 1994 WHO definition, densitometric osteoporosis prevalence among a non-Caucasian population should be in proportion to its relative osteoporotic fracture risk with Caucasian data as reference (16). To achieve this goal, various region/ethnic-specific reference BMD databases have been published (3). Furthermore, the cutpoint T-score for defining densitometric osteoporosis should be adjusted according to the osteoporotic fracture risk profile. Based on statistical modeling (3), we proposed that the femoral neck cutpoint T-score is revised from ≤−2.5 to ≤−2.75 for Hong Kong older women when a local BMD reference published by Lynn et al. ( 17) is applied. The same principle can also be applied to Japanese older women if a local BMD reference published by Iki et al. is used (3,18). In an empirical study on women with radiographic vertebral FF as a surrogate clinical endpoint, we recently demonstrated that, at the mean age of around 74, a femoral neck T-score of −2.60 for Italian Caucasians is equivalent to Letter to the Editor