Discrimination of Nonobstructive Hypertrophic Cardiomyopathy From Hypertensive Left Ventricular Hypertrophy on the Basis of Strain Rate Imaging by Tissue Doppler Ultrasonography

Kato, Tomoko S.; Noda, Akiko; Izawa, Hideo; Yamada, Akira; Okihara, Koji; Nagata, Kazuya; Iwase, Mitsunori; Murohara, Toyoaki; Yokota, Mitsuhiro

doi:10.1161/01.cir.0000150334.69355.00

Cited by 190 publications

(129 citation statements)

References 43 publications

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“…In the present study, the T-LSSR/T-LS ratio and "√"-shaped strain-rate waveform were shown to be useful for the differentiation between HCM and HT, while the more classical and simple parameter, LS, also showed good sensitivity and specificity as has been reported by several other investigators [7,10]. However, the amplitudes of strain and strain rate depend profoundly upon the analysis algorithm, which may differ among ultrasound manufacturers.…”

Section: Clinical Implication Of Timing and Pattern Analysis Of Straisupporting

confidence: 77%

“…Although the left ventricular (LV) ejection fraction is usually preserved or increased in patients with hypertrophic cardiomyopathy (HCM) [1][2][3], reduced myocardial contraction, especially in the longitudinal direction, has been observed in HCM patients by tissue Doppler imaging (TDI) [4][5][6], Doppler strain-rate imaging [7] and 2-dimensional speckle tracking echocardiography (STE) [8][9][10]. On the other hand, there have been few reports on alterations in the timing of the systolic peak and the systolic waveform of the LV myocardial strain rate in patients with HCM.…”

Section: Introductionmentioning

confidence: 99%

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Characteristic systolic waveform of left ventricular longitudinal strain rate in patients with hypertrophic cardiomyopathy

et al. 2016

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We analyzed the waveform of systolic strain and strain-rate curves to find a characteristic left ventricular (LV) myocardial contraction pattern in patients with hypertrophic cardiomyopathy (HCM), and evaluated the utility of these parameters for the differentiation of HCM and LV hypertrophy secondary to hypertension (HT). From global strain and strain-rate curves in the longitudinal and circumferential directions, the time from mitral valve closure to the peak strains (T-LS and T-CS, respectively) and the peak systolic strain rates (T-LSSR and T-CSSR, respectively) were measured in 34 patients with HCM, 30 patients with HT and 25 control subjects. The systolic strain-rate waveform was classified into 3 patterns ("V", "W", and "√" pattern). In the HCM group, T-LS was prolonged, but T-LSSR was shortened; consequently, T-LSSR/T-LS ratio was distinctly lower than in the HT and control groups. The "√" pattern of longitudinal strain-rate waveform was more frequently seen in the HCM group (74%) than in the control (4%) and HT (20%) groups. Similar but less distinct results were obtained in the circumferential direction. To differentiate HCM from HT, the sensitivity and specificity of the T-LSSR/T-LS ratio <0.34 and the "√"-shaped longitudinal strain-rate waveform were 85% and 63%, and 74% and 80%, respectively. In conclusion, in patients with HCM, a reduced T-LSSR/T-LS ratio and a characteristic "√"-shaped waveform of LV systolic strain rate was seen, especially in the longitudinal direction. The timing and waveform analyses of systolic strain rate may be useful to distinguish between HCM and HT.

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Section: Clinical Implication Of Timing and Pattern Analysis Of Straisupporting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Characteristic systolic waveform of left ventricular longitudinal strain rate in patients with hypertrophic cardiomyopathy

et al. 2016

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“…In the nondialysis population, GLS is proved as a more reliable and sensitive parameter for representing LV systolic function in patients with cardiomyopathies, advanced-stage CKD, or HF with preserved LVEF (11,12,(27)(28)(29)(30). Less negative GLS is also proved as a powerful predictor of all-cause mortality in the general population (9), and is reported to be useful in the preclinical diagnosis of a number of other cardiomyopathies, including diabetes, hypertrophic cardiomyopathy, and amyloidosis (28)(29)(30). In these cardiomyopathies, only GLS precedes any clinical evidence of overt systolic dysfunction, suggesting that abnormal GLS may represent an early stage of abnormal LV geometry and function.…”

Section: Discussionmentioning

confidence: 99%

Association of Left Ventricular Longitudinal Strain with Mortality among Stable Hemodialysis Patients with Preserved Left Ventricular Ejection Fraction

Liu¹,

Sung

et al. 2013

Clinical Journal of the American Society of Nephrology

101

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SummaryBackground and objectives Little is known about the optimal echocardiographic parameters for risk stratification in stable dialysis patients with preserved left ventricular ejection fraction (LVEF) (ejection fraction $50%). Left ventricular (LV) global peak systolic longitudinal strain (GLS) is the ratio of the maximal change in myocardial longitudinal length in systole to the original length and reliably and accurately assesses LV function. During systole, LV myocardium in the longitudinal direction shortens and GLS is represented by a negative value. The more negative value of GLS, the better the LV function is. This study hypothesized that subtle abnormalities of GLS are associated with an adverse prognosis.Design, setting, participants, & measurements This prospective study collected clinical and echocardiographic data (including GLS) from 88 stable hemodialysis patients (mean age 67.0611.2 years; 35% men) with preserved LVEF. These patients were enrolled from December 2008 to January 2009 and were followed-up for 25.669.9 months. The primary outcome was all-cause mortality. Multivariate Cox regression analysis was used to investigate risk factors for mortality.Results The mortality group (n=24) had lower albumin levels, less negative GLS, and higher prevalence of coronary artery disease and diabetes mellitus than the survival group. Using a GLS cutoff value of 215%, the less negative GLS group (GLS $215%) had a higher mortality rate. Cox regression analyses revealed that lower albumin level (hazard ratio, 0.16; 95% confidence interval, 0.05 to 0.53; P=0.003) and less negative GLS (hazard ratio, 3.57; 95% confidence interval, 1.41 to 9.04; P=0.01) were independent predictors of all-cause mortality. Furthermore, less negative GLS was associated with a higher cardiovascular death rate.Conclusions Less negative GLS is predictive of poor prognosis among stable hemodialysis patients with preserved LVEF.

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“…Numerous studies have elucidated the utility of strain rate imaging in the detection of myocardial diseases even in their subclinical stages, also as myocardial involvement in non-cardiac diseases, such as amyloidosis, diabetic heart disease, beta-thalassemia, Friedriech ataxia and others (74)(75)(76)(77)(78). It is also helpful in distinguishing between hypertrophic cardiomyopathy, athelete's heart and hypertrophy caused by hypertension (79,80). Nonetheless, in the case of global disease, where the site specificity of SR is not required, it remains unclear whether SR offers any advantages in comparison to tissue velocity (71).…”

Section: Figure 5 Normal Longitudinal Strain Pattern In the Color Dmentioning

confidence: 99%

Prediction of Short-Term Outcomes in Patients With Idiopathic Dilated Cardiomyopathy Referred for Transplantation Using Standard Echocardiography and Strain Imaging

Jasaitytė

Dandel

Lehmkuhl

et al. 2009

Transplantation Proceedings

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Discrimination of Nonobstructive Hypertrophic Cardiomyopathy From Hypertensive Left Ventricular Hypertrophy on the Basis of Strain Rate Imaging by Tissue Doppler Ultrasonography

Abstract: Background-The

Cited by 190 publications

References 43 publications

Characteristic systolic waveform of left ventricular longitudinal strain rate in patients with hypertrophic cardiomyopathy

Characteristic systolic waveform of left ventricular longitudinal strain rate in patients with hypertrophic cardiomyopathy

Association of Left Ventricular Longitudinal Strain with Mortality among Stable Hemodialysis Patients with Preserved Left Ventricular Ejection Fraction

Prediction of Short-Term Outcomes in Patients With Idiopathic Dilated Cardiomyopathy Referred for Transplantation Using Standard Echocardiography and Strain Imaging

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