Discrimination of Multiple Homologous Sequences Based on DNA Logic Gate and Elemental Labeling Technology
Qi Kang,
Beibei Chen,
Man He
et al.
Abstract:The simultaneous discrimination of multiple homologous sequences faces challenges due to the high similarity of sequences and the complexity of the discrimination system in most reported works. Herein, a simple and ingenious analysis method was developed to identify eight miRNAs of the let-7 family by combining logic gates and entropy-driven catalytic (EDC)-based lanthanide labeling inductively coupled plasma mass spectrometry (ICP-MS) technology. Specifically, eight miRNAs were first divided into four types a… Show more
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