Discrimination of hip fractures by quantitative ultrasound of the phalanges and the calcaneus and dual X-ray absorptiometry

Damilakis, John; Papadokostakis, George; Perisinakis, Kostas; Maris, Thomas G.; Dimitriou, P.; Hadjipavlou, Alexander; Gourtsoyiannis, Nicholas

doi:10.1016/j.ejrad.2004.01.023

Cited by 25 publications

(12 citation statements)

References 24 publications

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“…Prospective studies in postmenopausal women, showing that QUS can predict fracture risk independently of BMD, suggest that QUS may give us additional information such as the quality of bone [40][41][42][43] . This may be because QUS reflects micro-architectural or other mechanical properties of bone.…”

Section: Discussionmentioning

confidence: 97%

The role of quantitative ultrasound in predicting osteoporosis defined by dual-energy X-ray absorptiometry in pre- and postmenopausal women

Dane

Çetin

et al. 2008

Climacteric

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Section: Discussionmentioning

confidence: 97%

The role of quantitative ultrasound in predicting osteoporosis defined by dual-energy X-ray absorptiometry in pre- and postmenopausal women

Dane

Çetin

et al. 2008

Climacteric

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“…We found that all subjects in the lowest quartile for QUS measurements, 51.3% were also identified in the lowest quartiles for LS BMD, 45.9% for TB BMD and 37.8% for TB BMC measurements by DXA. In adults, phalangeal QUS has been shown to predict hip fractures independently of BMD as measured by DXA (Mele et al 1997;Damilakis et al 2004). In our subjects, those with previous fractures had lower DXA and phalangeal QUS values than teenagers without fractures, but these differences were not statistically significant except for TB BMD.…”

Section: Discussionmentioning

confidence: 99%

“…However, there appears to be no data available in the literature that has compared phalangeal QUS to total body and lumbar spine BMD measured by DXA in children and adolescents. Data in the adult population demonstrate some variances between these two techniques; however, it has not been established if this discordance also occurs in the pediatric population (Alenfeld et al 1998;Damilakis et al 2004).…”

Section: Introductionmentioning

confidence: 84%

Comparison of phalangeal ultrasound and dual energy X-ray absorptiometry in healthy male and female adolescents

Halaba¹,

Konstantynowicz

Pluskiewicz

et al. 2005

Ultrasound in Medicine & Biology

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“…Although this was the first investigation to assess the prospective ability of mQUS to predict fracture, other investigations have assessed this device retrospectively . Multiple investigations have compared the mQUS‐assessed SOS between fractured and unfractured cohorts to determine whether the mQUS could differentiate those who had suffered a fracture from those who had not.…”

Section: Discussionmentioning

confidence: 99%

Multisite quantitative ultrasound for the prediction of fractures over 5 years of follow-up: The Canadian Multicentre Osteoporosis Study

Olszynski

Brown

Adachi

et al. 2013

Journal of Bone and Mineral Research

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This study assessed the ability of multisite quantitative ultrasound (mQUS) to predict fracture over a 5-year follow-up. Participants were a subset of the Canadian Multicentre Osteoporosis Study. mQUS-assessed speed of sound (SOS in m/s) at three sites (distal radius, tibia, and phalanx) and extensive questionnaires were completed, after which participants were followed for 5 years and incident fractures recorded. Two survival analyses were completed for each site-a univariate analysis and an adjusted multivariate analysis controlling for age, antiresorptive use, femoral neck bone mineral density, number of diseases, previous fractures, body mass index (BMI), parental history of hip fracture, current smoking, current alcoholic drinks >3 per day, current use of glucocorticoids, and rheumatoid arthritis diagnosis (variables from the FRAX 10-year fracture risk assessment tool). The unit of change for regression analyses was one standard deviation for all measurement sites, specific to site and sex. Separate analyses were completed for all clinical fractures, nonvertebral fractures, and hip fractures by sex. There were 2633 women and 1108 men included, and they experienced 204 incident fractures over 5 years (5.5% fractured). Univariate models revealed statistically significant (p < 0.05) predictive ability of mQUS for all three measurement sites for women alone for all three fracture types (one standard deviation decrease in SOS was associated with a 52% to 130% increase in the risk of fracture), but not for the men's group. The adjusted model found that measures at the distal radius and tibia in the women's group could significantly (p < 0.05) predict all clinical fractures and nonvertebral fractures within the next 5 years (one standard deviation decrease in SOS was associated with a 25% to 31% increase in the risk of fracture). mQUS provided significant 5-year clinical fracture prediction in women, independent of bone mineral density and other significant risk factors for fracture, when measured at the distal radius and tibia sites.

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Discrimination of hip fractures by quantitative ultrasound of the phalanges and the calcaneus and dual X-ray absorptiometry

Cited by 25 publications

References 24 publications

The role of quantitative ultrasound in predicting osteoporosis defined by dual-energy X-ray absorptiometry in pre- and postmenopausal women

The role of quantitative ultrasound in predicting osteoporosis defined by dual-energy X-ray absorptiometry in pre- and postmenopausal women

Comparison of phalangeal ultrasound and dual energy X-ray absorptiometry in healthy male and female adolescents

Multisite quantitative ultrasound for the prediction of fractures over 5 years of follow-up: The Canadian Multicentre Osteoporosis Study

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