Discrimination of hie and hiesho using toe blood pressure in young women

Kimura, Takashi; Asami, Toyoko

doi:10.1016/s2095-4964(16)60286-8

Cited by 6 publications

(6 citation statements)

References 4 publications

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“…The desolvation temperature was 650˚C. Cyclo(l-Pro-d-Phe) was detected by measuring the corresponding mass traces in SIM mode by setting the [M 1 H] 1 . Cyclo(l-Pro-d-Phe) was detected at m/z 245.…”

Section: Methodsmentioning

confidence: 99%

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Roasted Barley Extract (Mugicha) Containing Cyclo(D-Phe-L-Pro) Prevents a Decrease in Skin Temperature in Cold Conditions: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study

Ashigai

Mizutani

Ikeshima

et al. 2019

J Nutr Sci Vitaminol

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Roasted barley extract (RBE) is a traditional Japanese beverage. Previously, we reported the effects of RBE containing cyclo(d-Phe-l-Pro) on blood flow in animals and humans and investigated rapid skin temperature recovery from cold-water immersion in women. The present randomized, double-blind study investigated the effects of RBE containing cyclo(d-Phe-l-Pro) on men's and women's skin temperature in excessively air-cooled conditions. Participants felt cold in the test room (25.560.5˚C). They ingested an RBE or placebo beverage and remained in the air-conditioned room for 100 min. Skin temperature of the left foot was measured every 5 min using infrared thermography. We evaluated effect of RBE administration by paired t-test. The skin temperature of the RBE group remained higher than that of the placebo group. The skin temperature changes 100 min after RBE or placebo ingestion were 23.6761.14˚C and 24.5960.89˚C, respectively in all participants. We also did subclass analysis focusing on men or women. In a previous study, RBE efficacy for skin temperature in men was not clearly demonstrated. RBE consumption was also effective not only in female participants but also in male participants. The skin temperature changes 100 min after RBE or placebo ingestion were 23.6560.64˚C and 24.5560.32˚C, respectively in male participants. Therefore, RBE containing cyclo(d-Phe-l-Pro) prevented skin temperature decreases in excessively air-cooled conditions in both men and women.

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Section: Methodsmentioning

confidence: 99%

“…The sensation of cold (hiesho) is known as blood stasis in traditional Chinese medicine (1,2). It causes a decreased quality of life because it leads to various vascular diseases, such as hypertension and arteriosclerosis (3,4).…”

mentioning

confidence: 99%

Roasted Barley Extract (Mugicha) Containing Cyclo(D-Phe-L-Pro) Prevents a Decrease in Skin Temperature in Cold Conditions: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study

Ashigai

Mizutani

Ikeshima

et al. 2019

J Nutr Sci Vitaminol

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“…Subjects sat in chairs without moving. 11 Then, subjects removed their socks and ingested their beverages. The beverage temperature was 25 °C for adjusting the beverage temperature to be the same as the room temperature.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

“…Before the intake of beverages, we measured the cutaneous blood flow and skin temperature (pre-intake data, 0 min). Subjects sat in chairs without moving . Then, subjects removed their socks and ingested their beverages.…”

Section: Methodsmentioning

confidence: 99%

“…Cold sensation (hiesho) is known as blood stasis (oketsu) in traditional Chinese medicine. , It decreases the quality of life and can be related to various vascular diseases, such as hypertension and arteriosclerosis. , Cold sensation is caused by an imbalance of the autonomic nerve system, which causes vasoconstriction and lowers cutaneous blood flow. , Blood flow plays a role in controlling the body temperature . Thus, decreased skin temperature leads to a decline in cutaneous blood flow …”

Section: Introductionmentioning

confidence: 99%

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Roasted Barley Extract (Mugi-cha) Containing Cyclo(d-Phe-l-Pro) Prevents Lowering of the Cutaneous Blood Flow and Skin Temperature under Air Conditioning: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study

Ashigai

Mizutani

Taniguchi

et al. 2018

J. Agric. Food Chem.

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Roasted barley extract (RBE), also known as mugi-cha, is a well-known healthy non-caffeinated beverage, and its health functionality has been widely reported. Our previous clinical study showed that RBE affects the cutaneous blood flow and skin temperature after cold-water immersion and that cyclo(d-Phe-l-Pro) is responsible for its effect. In this study, we investigated whether cyclo(d-Phe-l-Pro)-containing RBE prevents the decrease in the cutaneous blood flow and skin temperature. Subjects remained in the air-conditioned room while ingesting RBE or a placebo. We measured the cutaneous blood flow and skin temperature. We evaluated the effect of RBE administration by two-way repeated measures analysis of variance. A total of 15 subjects were enrolled. The change in cutaneous blood flow in the RBE and placebo groups was -0.79 ± 0.38 and -2.03 ± 0.35 mL min 100 g, respectively ( p value of 0.041). The change in the skin temperature in the RBE and placebo groups was -1.85 ± 0.35 and -3.02 ± 0.30 °C, respectively ( p value of <0.001). We also did subclass analysis with cold-feeling subjects. For the seven subjects who had cold sensation, the change in the cutaneous blood flow in the RBE and placebo groups was -0.48 ± 0.58 and -2.56 ± 0.48 mL min 100 g, respectively ( p value of 0.008). The change in the skin temperature in the RBE and placebo groups was -1.46 ± 0.74 and -2.89 ± 0.39 °C, respectively ( p value of 0.009). Thus, RBE containing cyclo(d-Phe-l-Pro) prevents the decrease in the cutaneous blood flow and skin temperature under air conditioning.

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Convolutional neural network-based computer-aided diagnosis in Hiesho (cold sensation)

Wang

Endo

Ohno

et al. 2022

Computers in Biology and Medicine

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Discrimination of hie and hiesho using toe blood pressure in young women

Cited by 6 publications

References 4 publications

Roasted Barley Extract (Mugicha) Containing Cyclo(D-Phe-L-Pro) Prevents a Decrease in Skin Temperature in Cold Conditions: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study

Roasted Barley Extract (Mugicha) Containing Cyclo(D-Phe-L-Pro) Prevents a Decrease in Skin Temperature in Cold Conditions: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study

Roasted Barley Extract (Mugi-cha) Containing Cyclo(d-Phe-l-Pro) Prevents Lowering of the Cutaneous Blood Flow and Skin Temperature under Air Conditioning: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study

Convolutional neural network-based computer-aided diagnosis in Hiesho (cold sensation)

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