Discriminating Preoperative Features of Pleuropulmonary Blastomas (PPB) from Congenital Cystic Adenomatoid Malformations (CCAM): a Retrospective, Age-Matched Study

Oliveira, Carol; Himidan, Sharifa; Pastor, Aimee C.; Nasr, Ahmed; Manson, David; Taylor, Glenn; Yanchar, Natalie; Brisseau, Guy F.; Kim, P. C. W.

doi:10.1055/s-0030-1267923

Cited by 54 publications

(40 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both infants recovered fully. It has been reported that PPB may be indistinguishable from CCAM radiologically in a retrospective case-matched series 39. However, this series relied on small numbers and described only infants who presented postnatally and were symptomatic in 9/10 of cases.…”

Section: Discussionmentioning

confidence: 99%

Conservative management of antenatally diagnosed cystic lung malformations

Stanwell

Burge

et al. 2014

Archives of Disease in Childhood

View full text Add to dashboard Cite

This retrospective cohort study of 74 consecutive CLMs diagnosed antenatally over a 10-year period demonstrates that most of these lesions will remain asymptomatic throughout childhood. Although the natural history of CLMs in later years remains to be elucidated, we hope that this report on medium-term outcomes will be useful to clinicians who undertake antenatal counselling and may inform the discussion on how best to manage these children.

show abstract

Section: Discussionmentioning

confidence: 99%

Conservative management of antenatally diagnosed cystic lung malformations

Stanwell

Burge

et al. 2014

Archives of Disease in Childhood

View full text Add to dashboard Cite

show abstract

“…PPB presents a diagnostic challenge since it is difficult to distinguish from benign lung lesions either prenatally or in early childhood [2,3,4]. Thus, the diagnosis is most often only made by histology.…”

Section: Discussionmentioning

confidence: 99%

“…A solid type III tumor is more pathognomonic but typically presents in older children [2]. A strong family history of neoplasia can prompt suspicion for PPB but is positive in only 40% of cases [1,3]. …”

Section: Discussionmentioning

confidence: 99%

Pleuropulmonary Blastoma in a Neonate Diagnosed Prenatally as Congenital Pulmonary Airway Malformation

Coleman¹,

Kline‐Fath

Stanek³

et al. 2015

Fetal Diagn Ther

View full text Add to dashboard Cite

Pleuropulmonary blastoma is an extremely rare lung neoplasm exclusive to children under 5 years of age. It presents a diagnostic challenge both prenatally and in early childhood due to its similarity to benign lung cysts, which are managed differently. We present the first case, to our knowledge, of a neonate with pleuropulmonary blastoma and myelomeningocele, though prenatally diagnosed as a congenital pulmonary airway malformation. We detail the prenatal imaging that facilitated counseling and delivery management in addition to the correlating postnatal imaging.

show abstract

“…A pathological classification system was proposed by Stocker et al and later expanded to include types 0 to 4 [4–6]. However, there is often discrepancy between the type of CPAM based on imaging and the ultimate pathological diagnosis after resection [7–9]. …”

mentioning

confidence: 99%

Can congenital pulmonary airway malformation be distinguished from Type I pleuropulmonary blastoma based on clinical and radiological features?

Feinberg

Hall

Williams

et al. 2016

Journal of Pediatric Surgery

104

View full text Add to dashboard Cite

Background The management of congenital cystic lung lesions is controversial. Arguments for routine resection during infancy include the possibility of the lesion being Type I pleuropulmonary blastoma (PPB) rather than a cystic congenital pulmonary airway malformation (CPAM). We aimed to identify clinical and radiological features that might distinguish between CPAM and PPB and to develop a diagnostic algorithm based on these features. Methods All recorded cases of Type I PPB were retrieved from the International PPB Registry and compared with an institutional cohort of children undergoing resection of CPAM (2002–2013) that was noted at some stage to be at least partially cystic. Regression models were created to identify variables that might differentiate CPAM from PPB. Odds ratio (OR) and positive predictive value (PPV) were calculated for each variable and a decision algorithm developed. Results In 112 cases of Type I PPB and 103 of CPAM, factors favoring a diagnosis of CPAM included prenatal detection (OR 89.4), systemic feeding vessel (OR 61.7), asymptomatic (OR 8.0), and hyperinflated lung (OR 6.6). Factors favoring a diagnosis of PPB included bilateral or multisegment involvement (OR 2.4). A decision algorithm that helps to identify lesions requiring resection and those which can be safely observed is presented. Conclusion Clinical and radiological features can help to differentiate between CPAM and PPB. Our algorithm allows identification of children at higher risk of PPB in whom we would recommend resection and those at low risk in whom continued close observation is safe.

show abstract

Discriminating Preoperative Features of Pleuropulmonary Blastomas (PPB) from Congenital Cystic Adenomatoid Malformations (CCAM): a Retrospective, Age-Matched Study

Cited by 54 publications

References 12 publications

Conservative management of antenatally diagnosed cystic lung malformations

Conservative management of antenatally diagnosed cystic lung malformations

Pleuropulmonary Blastoma in a Neonate Diagnosed Prenatally as Congenital Pulmonary Airway Malformation

Can congenital pulmonary airway malformation be distinguished from Type I pleuropulmonary blastoma based on clinical and radiological features?

Contact Info

Product

Resources

About