Discriminating breeding values of young bulls from their serum concentrations of hormones

Gill, J. L.; Pirchner, F.; Schab, Magdalena

doi:10.1111/j.1439-0388.1986.tb00086.x

Cited by 3 publications

(4 citation statements)

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“…Outliers were checked using a procedure suggested by G ill et al (1986). Their procedure is based on the method of S hapiro and W ilk (1965) that tests non‐normality in small samples.…”

Section: Methodsmentioning

confidence: 99%

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Relationship between plasma hormone and metabolite levels and breeding values of bulls¹

Graml

Olbrich‐Bludau

Schwab

et al. 1995

J Animal Breeding Genetics

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Summary Blood plasma levels of the hormones bovine growth hormone (bGH), insulin and insulin‐like growth factor 1 (IGF‐1) and the metabolites glucose, free fatty acids (FFA), urea, creatine and creatinine in 70 bulls (Fleckvieh, Braunvieh, Grauvieh) kept at four AI stations were measured. Plasma determinations were performed on day 1 with normal feeding (N), day 4 after fast (F), and day 5 (R) after realimentation. Fleckvieh bulls had lower bGH but higher IGF‐1 levels than Braunvieh bulls; young bulls had lower IGF‐1 and insulin but higher glucose levels than mature bulls. The effect of fasting led to higher plasma levels of FFA, urea and creatinine and to lower levels of bGH and IGF‐1. Correlations between plasma levels and breeding values for yield of milk, fat and protein were estimated for mature bulls. All three breeding values correlated positively with bGH and negatively with insulin, while correlations with other indicators depended on the feeding status of bulls. Prediction equations for breeding values which were limited to three indicators, included FFA, urea, and creatinine, and the r2 values ranged up to 0.32. Validation of these equations, derived from Fleckvieh bulls, on Braunvieh and Grauvieh bulls resulted in correlations of about 0.2. The use of indicators, in addition to information from relatives (dam, full and half‐sisters), improves the accuracy of selection of young bulls. Zusammenfassung Beziehungen zwischen Plasmahormon und ‐metabolitenspiegel in Milchzuchtwerten Von 70 Bullen der Rassen Fleckvieh, Braunvieh und Tiroler Grauvieh aus vier Besamungsstationen wurden die Blutkonzentrationen der Hormone bGH, IGF‐1 und Insulin sowie die der Metaboliten Glucose, Freie Fettsäuren (FFA), Harnstoff, Kreatin und Kreatinin während normaler Fütterung (N), nach einer Fastenperiode (F) und nach Wiederfütterung (R) bestimmt. Fleckviehbullen hatten signifikant mehr bGH und IGF‐1 als Braunviehbullen, Jungbullen signifikant weniger IGF‐1 und Insulin, aber mehr Glucose als ausgewachsene Bullen. Fasten der Tiere führte zu signifikant höherem Blutspiegel an Freien Fettsäuren, Harnstoff und Kreatin und zu niedrigerem Blutspiegel an bGH und IGF‐1. Korrelationen zwischen Blutserumspiegel und Zuchtwert für Milchmenge, Fettmenge und Proteinmenge wurden geschätzt. bGH hatte eindeutig einen positiven, Insulin einen negativen Zusammenhang zu alien Zuchtwerten, während er bei den anderen Blutparametern je nach Fütterungsstatus unterschiedlich war. Schätzungsgleichungen für Zuchtwerte aus drei Blutwerten wurden erstellt, die Freie Fettsäuren, Harnstoff und Kreatinin berücksichtigten. Validierungen der Schätzungsgleichungen für Fleckvieh an Braunvieh und Grauvieh ergaben Korrelationen von etwa 0,20. Die Wirksamkeit der Verwendung der Indikatoren zur Zuchtwertschätzung eines Jungbullen‐und MOET‐Nukleus‐Programm wurde untersucht und dabei jeweils die Genauigkeit der Schätzung aus Verwandten (Mutter, Voll‐bzw. Halbschwestern) deutlich erhöht.

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“…Outliers were checked using a procedure suggested by G ill et al (1986). Their procedure is based on the method of S hapiro and W ilk (1965) that tests non‐normality in small samples.…”

Section: Methodsmentioning

confidence: 99%

“…However, the gain in efficiency resulting from indicators would be less in adult MOET schemes. In progeny‐testing programmes indicator traits could be used for the initial selection of test bulls (G ill et al 1986).…”

Section: Introductionmentioning

confidence: 99%

Relationship between plasma hormone and metabolite levels and breeding values of bulls¹

Graml

Olbrich‐Bludau

Schwab

et al. 1995

J Animal Breeding Genetics

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“…Replicate within line, sex and sex by replicate within line were tested against the between mouse mean square. Prior to analyses, data for growth hormone were tested for outliers, and outliers were modified, as described in G ill et al (1986), following T ukey (1962). For serum GH, 3, 4, 2, 2 and 3 observations were modified in the EPA, EPR, LPA, LPR and Control lines, respectively.…”

Section: Methodsmentioning

confidence: 99%

“…As an aid to the biometrical approach, especially in the case of sex limited traits or traits expressed late in the animal's life, considerable interest has often focused on additonal information such as quantitative trait loci (QTL), marker genes, or physiological information providing indirect measures of genetic potential. There have been a considerable number of studies examining the possibilities of using physiological information, such as hormone levels in selection programs in farm animals (e. g. W ooliams and S mith 1988; M ackenzie et al 1988; S innett ‐S mith et al 1987; G ill et al 1986; H ill 1985; S ejrsen et al 1984). Indirect information on the association between physiological information and genetic potential can also come from correlated responses in physiological parameters to selection for growth in laboratory animals (e. g. P idduck and F alconer 1978, Y ani and N agasawa 1968; S inha et al 1975).…”

Section: Introductionmentioning

confidence: 99%

Correlated responses in growth hormone to selection for weight gain in mice

Moride

Hayes

1993

J Animal Breeding Genetics

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Correlated responses in pituitary gland weight and growth hormone (GH) concentration in the serum and pituitary were studied in lines of mice selected for growth rate, and in controls. The selection criteria were weight gain between 28 and 38 days on an ad libitum feed intake (EPA line), or on intake restricted to 80% of the control mice (EPR line), and weight gain between 48 and 58 days under the above two feeding regimes (LPA and LPR lines). The control line was maintained by random breeding. In generation 13, pituitary weight and growth hormone levels were determined at 38 days in lines EPA, EPR and the control and at 58 days in lines LPA, LPR and the control. Pituitary weight, corrected for body weight gain, was smaller in the EPA line than in the control line at 38 days and was greater in the LPR line than in the control line at 58 days. There were large differences in serum GH concentrations between the selected lines and the control; the differences were statistically significant at 38 days, with the EPA and EPR lines having lower levels than the controls. ZUSAMMENFASSUNG: Veränderung von Wachstumshormonspiegel bei Selektion für Zuwachs bei Mäusen Veränderungen im Hypophysengewicht und Wachstumshormon-(GH)-Konzentrationen im Serum und in der Hypophyse wurden bei Wachstumsselektionslinien und bei Kontrollmäusen untersucht. Selektionskriterien waren Zuwachs zwischen 28 und 38 Tagen bei ad libitum Futteraufnahme (EPA Linie) oder bei Linien, wo Futteraufnahme auf 80% derjenigen der Kontrollmäuse (EPR Linie) begrenzt wurde und Zuwachs zwischen 48 und 58 Tagen unter beiden Futterweisen (LPA und LPR Linie). Die Kontrollinie wurde durch Zufallspaarung fortgepflanzt. In Generation 13 wurden Hypophysengewicht und Wachstumshormonspiegel im Alter von 38 Tagen in Linien EPA, EPR und in Kontrollen und bei 58 Tagen in Linien LPA und LPR und Kontrollen bestimmt. Hypophysengewicht, korrigiert für Zuwachs, war geringer in der LPA Linie als in der Kontrolle bei 38 Tagen Alter und größer in der LPR Linie als in der Kontrolle bei 58 Tagen. Zwischen GH Konzentrationen selektierter und Kontrollinien waren erhebliche Differenzen, die bei 38 Tagen signifikant waren, wobei EPA und EPR Linien geringere Werte als die Kontrollen aufwiesen.

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The value of indicator traits in the genetic improvement of dairy cattle

Woolliams

Smith

1988

Anim. Prod.

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The value of indicator traits (7), such as physiological or biochemical traits in the genetic improvement of dairy cattle for milk yield (M) was studied. First, some corrections were made to the base rates of genetic change possible by improvement systems based on progeny testing and on multiple ovulation and embryo transfer (MOET), and on combinations of these. Efficient field progeny-testing systems can be competitive with current adult MOET nucleus herd schemes but juvenile MOET nucleus herd schemes offer substantial increases in rates of response. With high co-heritability, selection for the T alone may allow greater rates of response than those currently considered feasible using progeny testing. However, faster rates are obtained with combined selection. When breeding values are accurately measured by pedigree and performance records on M, as in the progeny test, the extra rates of response with combined selection may be small. Where breeding values are less accurately assessed, as in juvenile MOET nucleus schemes, the extra rates of response can be appreciable. For T with co-heritability (h M r G h T ) of 0-27 and the CV for M from 0-15 to 0-20, response rates of 2 0 to 2-7% of the mean per year possible by traditional methods could be increased to 2-2 to 2-9% in progeny testing schemes, 2-3 to 3-1% and to 4-3 to 5-7% for adult and juvenile MOET nucleus schemes respectively.A possible useful indicator trait is blood urea nitrogen (BUN) measured in young animals after a short fast. Results from four experiments with calves having high or low genetic merit for M were summarized. The pooled co-heritability estimate was -0-27 (s.e. 005). With this, or even a more modest effect, BUN would be a useful indicator trait in selection for milk production. Its use in practice in high and low selection lines or in a section of the industry, would allow assessment of the merit of the method.

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Discriminating breeding values of young bulls from their serum concentrations of hormones

Cited by 3 publications

References 5 publications

Relationship between plasma hormone and metabolite levels and breeding values of bulls¹

Relationship between plasma hormone and metabolite levels and breeding values of bulls¹

Correlated responses in growth hormone to selection for weight gain in mice

The value of indicator traits in the genetic improvement of dairy cattle

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Discriminating breeding values of young bulls from their serum concentrations of hormones

Cited by 3 publications

References 5 publications

Relationship between plasma hormone and metabolite levels and breeding values of bulls1

Relationship between plasma hormone and metabolite levels and breeding values of bulls1

Correlated responses in growth hormone to selection for weight gain in mice

The value of indicator traits in the genetic improvement of dairy cattle

Contact Info

Product

Resources

About

Relationship between plasma hormone and metabolite levels and breeding values of bulls¹

Relationship between plasma hormone and metabolite levels and breeding values of bulls¹