Discriminant Validity Study of Ultrasound Achilles Enthesis

Molinero, María Rosa Expósito; Mendieta, Eugenio de Miguel

doi:10.1016/j.reumae.2015.08.002

Cited by 2 publications

(7 citation statements)

References 14 publications

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“…As previously reported ( 19 ), we found significantly more structural changes/thickening and bone erosion in the Achilles tendon in SpA than in gout. This enthesis seems to be the most affected in SpA according to what has been reported ( 7 , 25 ).…”

Section: Discussionsupporting

confidence: 90%

“…de Miguel and cols, using MASEI had demonstrated that the presence of PD signal and bone erosion have a better predictive value for inflammatory enthesitis in SpA ( 21 ). Besides, as we have observed a higher prevalence of bone erosions in SpA than in gout, another study has found similar results ( 19 ). In a systematic review, significantly more erosions in the calcaneal enthesis were observed in SpA compared with the healthy population ( 26 ).…”

Section: Discussionsupporting

confidence: 79%

“…Although the US has proven to be a reliable and valid technique to evaluate enthesitis in SpA ( 23 ), little has been analyzed about its discriminant validity. In a study, the power of discrimination of US was evaluated by MASEI between different chronic diseases in the Achilles enthesis, showing that this index lacks validity to discriminate SpA from gout ( 19 ). Probably the fact that there is a single enthesis being assessed, limits the possibility of establishing the discriminant validity of an imaging technique.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have demonstrated the ability of US to differentiate it from other microcrystalline arthropathies in joints ( 16 – 18 ). However, little has been studied about the discriminant capacity of the US at the entheses level ( 19 ). In one study that evaluated the discriminant validity of US in SpA, rheumatoid arthritis, gout, chondrocalcinosis, and osteoarthritis in the Achilles tendon, the US shows a potential ability to differentiate between SpA and the other diseases, except for gout ( 19 ).…”

Section: Introductionmentioning

confidence: 99%

“…However, little has been studied about the discriminant capacity of the US at the entheses level ( 19 ). In one study that evaluated the discriminant validity of US in SpA, rheumatoid arthritis, gout, chondrocalcinosis, and osteoarthritis in the Achilles tendon, the US shows a potential ability to differentiate between SpA and the other diseases, except for gout ( 19 ). So far, the ability of the US to discriminate between SpA and gout has not been evaluated through the identification of elemental lesions of each of these pathologies with MASEI.…”

Section: Introductionmentioning

confidence: 99%

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Entheseal Involvement in Spondyloarthritis (SpA) and Gout: An Ultrasound Comparative Study

et al. 2022

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ObjectiveTo compare the assessment of entheses in subjects with spondyloarthritis (SpA) with patients with gout by the Madrid Sonographic Enthesis Index (MASEI).MethodThis cross-sectional study includes videos of entheses evaluated by ultrasound (US) of 30 patients with SpA diagnosed according to the ASAS criteria and 30 patients with gout established by the presence of monosodium urate crystals. Entheses were evaluated for MASEI in 2 Institutes located in two different countries. Demographic and clinical data were registered. Total MASEI score, MASEI-inflammatory, and MASEI-chronic damage were analyzed. Comparisons between groups were obtained by chi-square test and Student's t-test. An inter-reading US reliability was realized.ResultsPatients with gout were older and had significantly more comorbidities than those with SpA. The total MASEI score was not significantly different among diseases (p = 0.07). MASEI-inflammatory was significantly more prevalent at the Achilles tendon in SpA, while the proximal patellar tendon was in gout. Power Doppler was higher in SpA compared to gout (p = 0.005). MASEI-chronic damage related to calcification/enthesophytes predominated in gout (p = 0.043), while calcaneal erosions did in SpA (p = 0.008). The inter-reader concordance was excellent (0.93, CI 95% 0.87–0.96, p = 0.001).ConclusionsSpA and gout similarly involve entheses according to MASE, however, some inflammatory and chronic lesions differ significantly depending on the underlying disease and tendon scanned.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Entheseal Involvement in Spondyloarthritis (SpA) and Gout: An Ultrasound Comparative Study

et al. 2022

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Defining the extracellular matrix in non-cartilage soft tissues in osteoarthritis – a systematic review

Mimpen,

Raza,

Snelling

2023

Preprint

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Objective Osteoarthritis (OA) is increasingly seen as a disease of global joint dysfunction, affecting not only cartilage but also the other joint tissues. Extracellular matrix (ECM) is a critical determinant of tissue mechanobiology, but ECM is poorly understood in osteoarthritic joint tissues beyond cartilage in human OA and animal models of OA. Therefore, we aimed to define the structural composition and architecture of non-cartilage soft joint tissue ECM in human OA, and to compare the ECM changes observed in humans to those seen in animal models of OA. Methods A systematic search strategy, devised using relevant matrix, tissue, and disease nomenclature, was run through the MEDLINE, EMBASE, and Scopus databases. Demographic, clinical, and biological data were extracted from eligible studies. Bias analysis was performed. Results 142 studies were included, which covered capsule, ligaments, meniscus, skeletal muscle, synovium, and tendon in both humans and animals, and fat pad and intervertebral disc in humans only. Overall, included studies show that the expression of structural ECM components changes in disease within an ECM that becomes disorganised with increasing joint degeneration. Conclusions This systematic review consolidates existing knowledge of a poorly defined aspect of OA pathophysiology. Changes in ECM composition and architecture occur across soft joint tissues in OA, but most of these remain poorly defined due to the low number of studies and lack of healthy comparator groups. Further research to better understand the context within which cartilage is damaged in OA may enable a better understanding of OA and its potential treatments.

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Discriminant Validity Study of Ultrasound Achilles Enthesis

Cited by 2 publications

References 14 publications

Entheseal Involvement in Spondyloarthritis (SpA) and Gout: An Ultrasound Comparative Study

Entheseal Involvement in Spondyloarthritis (SpA) and Gout: An Ultrasound Comparative Study

Defining the extracellular matrix in non-cartilage soft tissues in osteoarthritis – a systematic review

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