Discrete regional distributions of thyrotropin releasing hormone (TRH) receptor binding in monkey central nervous system

Thyrotropin-releasing hormone receptors -- similarities and differences

“…The distribution pattern of TRH binding sites has also been studied in dissected tissues (Burt & Taylor 1980, Ogawa et al 1981, Simasko & Horita 1982, Taylor & Burt 1982 or by using quantitative binding autoradiography (Manaker et al 1985, Mantyh & Hunt 1985, Pazos et al 1985, Sharif & Burt 1985, Sharif 1989. These findings are in good agreement with the distributions of TRH-R1 and TRH-R2 found by in situ hybridization, although differences in the levels of expression estimated by the different methods are found.…”

Immunohistochemical localization of thyrotropin-releasing hormone in the brain of reptiles

“…The wide distribution of TRH receptors in the brain of several mammalian species (Burt and Taylor, 1980;Ogawa et al, 1981;Taylor and Burt, 1982;Wu et al, 1992;Satoh et al, 1993;Calza et al, 1992;Mitsuma et al, 1995;O'Dowd et al, 2000;Heuer et al, 2000) corroborates this fact, relating this neuropeptide with analgesia (Boschi et al, 1983;Tanabe et al, 2007), arousal and sexual excitation (Prange, 1974;Horita et al, 1976;Ervin et al, 1981;Rezvani et al, 1997;Horita, 1998), thermoregulation (Fiedler et al, 2006;Schuhler et al, 2007), food intake behavior (Ao et al, 2006;Gotoh et al, 2007), dream control (Reichlin, 1986) and autonomic functions (Helke and Phillips, 1988), among others.…”

Effects of Thyrotropin-Releasing Hormone and Its Analogs on Daytime Sleepiness and Cataplexy in Canine Narcolepsy

“…The affinities of TRH and TRH analogs for canine TRH receptors were studied in vitro using [ 3 H]methyl-TRH binding (New England Nuclear; specific activity of 84.3 C i /mol) according to the methods described by Ogawa et al (1981). The cortex of normal Doberman pinschers was used for this study.…”