2009
DOI: 10.1161/atvbaha.109.193227
|View full text |Cite
|
Sign up to set email alerts
|

Discrete Contributions of Elastic Fiber Components to Arterial Development and Mechanical Compliance

Abstract: Objective-Even though elastin and fibrillin-1 are the major structural components of elastic fibers, mutations in elastin and fibrillin-1 lead to narrowing of large arteries in supravascular aortic stenosis and dilation of the ascending aorta in Marfan syndrome, respectively. A genetic approach was therefore used here to distinguish the differential contributions of elastin and fibrillin-1 to arterial development and compliance. Methods and Results-Key parameters of cardiovascular function were compared among … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

8
59
2
1

Year Published

2010
2010
2021
2021

Publication Types

Select...
6
1

Relationship

3
4

Authors

Journals

citations
Cited by 74 publications
(70 citation statements)
references
References 27 publications
8
59
2
1
Order By: Relevance
“…The curves become nonlinear just beyond the stretch ratio at the systolic pressure for all ages and genotypes, acting to limit distension of the arterial wall under high pressure. The similar stress-stretch curves for WT and Eln ϩ/Ϫ arteries are consistent with previous data for adult mice (2,25) and show the remarkable adaptation of developing arteries. The curves do not depend on the amount of elastin in the wall but may depend on the functionality of the deposited elastin.…”
Section: Discussionsupporting
confidence: 91%
See 3 more Smart Citations
“…The curves become nonlinear just beyond the stretch ratio at the systolic pressure for all ages and genotypes, acting to limit distension of the arterial wall under high pressure. The similar stress-stretch curves for WT and Eln ϩ/Ϫ arteries are consistent with previous data for adult mice (2,25) and show the remarkable adaptation of developing arteries. The curves do not depend on the amount of elastin in the wall but may depend on the functionality of the deposited elastin.…”
Section: Discussionsupporting
confidence: 91%
“…Blood pressure is significantly increased in Eln ϩ/Ϫ mice at P14, which is later in development than significant reductions in the aortic pressurediameter and -compliance relationships at P7, supporting our hypothesis that changes in mechanical properties precede changes in blood pressure in these mice. The differences in the mechanical behavior between WT and Eln ϩ/Ϫ arteries for P7-60 are similar to those determined in previous studies for adult arteries with reduced elastin levels (8,11,25) and with defects in other elastic fiber proteins (2,6,26). The combination of changes in mechanical behavior and blood pressure allows WT and Eln ϩ/Ϫ aortas to have similar diameters at systolic pressure for all ages, which may be a mechanism to maintain cardiac output and constant shear stress.…”
Section: Discussionsupporting
confidence: 83%
See 2 more Smart Citations
“…Decreased abundance of these proteins and general dysregulation of their normally coordinated and time-dependent synthesis likely precludes the normal protein-protein and protein-cell surface interactions on which aortic development and structural integrity depend. 41,42 According to this model, TGF-␤ signaling stimulates elastogenesis and regulates vessel caliber by upregulating expression of not 1 but several ECM proteins.…”
Section: Jaffe Et Al Tgf-␤ Signaling and Vascular Development E9mentioning
confidence: 99%