Discrepant clinical responses and blood chemokine profiles between two non‐steroidal anti‐inflammatory medications for children with mild persistent asthma

Hung, Chih‐Hsing; Li, Chi Yuan; Lai, Yaxin; Hsu, Pei-Chen; Hua, Yi Ming; Yang, Kuender D.

doi:10.1111/j.1399-3038.2005.00273.x

Cited by 20 publications

(17 citation statements)

References 16 publications

(23 reference statements)

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“…At present the mechanism through which CCL17 induced NOS2 is not evident but these findings are in agreement with a previous clinical study showing that therapeutic improvement in pediatric asthma was associated with decreased NO and CCL17. 50 The present study also demonstrated that CCL22 inhibited the expression of Arg1 in WT but not CCR4 Ϫ/Ϫ macrophages. The inhibitory effect of CCL22 on Arg1 expression is not readily explained by previously published observations.…”

Section: Discussionsupporting

confidence: 57%

A Novel Mechanism for CCR4 in the Regulation of Macrophage Activation in Bleomycin-Induced Pulmonary Fibrosis

Trujillo

O'Connor

Kunkel

et al. 2008

The American Journal of Pathology

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Section: Discussionsupporting

confidence: 57%

A Novel Mechanism for CCR4 in the Regulation of Macrophage Activation in Bleomycin-Induced Pulmonary Fibrosis

Trujillo

O'Connor

Kunkel

et al. 2008

The American Journal of Pathology

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“…Polyinosinic:polycytidylic acids [poly(I:C)] is a synthetic mimetic of dsRNA and functions through an endosomal receptor, such as Tolllike receptor 3, or cytosolic receptors and can activate innate immunity [22]. MDCs play a role not only in asthma but also in allergic rhinitis [8,24]. MDCs were increased in the exhaled breath condensate and plasma in children with asthma [25].…”

Section: Discussionmentioning

confidence: 98%

“…LPS can induce the Th1-related chemokine (IP-10) and the Th2-related chemokine (MDC) production in human monocytes [10]. In addition, the Th1-and Th2-related chemokines play an important role in human allergic asthma [8,9,20]. Several anti-allergic or anti-asthmatic medications, such as mast cell stabilizers and leukotriene receptor antagonists, have some effects on chemokine expression or chemokine-induced chemotaxis [10,21].…”

Section: Discussionmentioning

confidence: 99%

“…The Th1-related chemokine, interferon-inducible protein 10 (IP-10) /CXCL10 is also involved in the human allergic pulmonary reaction [7]. Finally, plasma IP-10 and MDC levels are increased in asthmatic children [8,9]. Our previous data showed that LPS could induce Th1-related chemokine (IP-10) and Th2-related chemokine (MDC) production in human monocytes [10].…”

Section: Introductionmentioning

confidence: 96%

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Effects of All-Trans Retinoic Acid on Th1- and Th2-Related Chemokines Production in Monocytes

Tsai¹,

Chang²,

Chang³

et al. 2008

Inflammation

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Low vitamin C and reduced alpha-carotene intake are associated with increased asthma risk in children. In addition, mean serum vitamin A concentrations are significantly lower in asthmatic children than in controls. All-trans retinoic acid (ATRA) is a derivative of vitamin A. Macrophage-derived chemokine (MDC) is a T helper cell-type 2 (Th2)-related chemokine involved in the recruitment of Th2 cells toward inflammatory sites. On the other hand, Th1-related chemokine, interferon-inducible protein 10 (IP-10)/CXCL10 is also important in allergic inflammation. Both Th1- and Th2-related chemokines play an important role in allergic asthma. To survey whether ATRA and ascorbic acid effect Th1- and Th2-related chemokine expression in monocytes. To test this, THP-1 cells were pre-treated with ATRA or ascorbic acid and stimulated by lipopolysaccharide (LPS) or poly I:C. Supernatants were measured for Th2-related (MDC) and Th1-related (IP-10) chemokine concentrations by ELISA. The effects of ATRA on mitogen-activated protein kinase (MAPK) and NFkb were evaluated with Western blotting. After stimulation, ATRA significantly down-regulated MDC and IP-10 in a dose-dependent manner. Similarly, ascorbic acid reduced the LPS-induced changes in MDC but only with a high dose. However, asorbic acid had no effect on IP-10 changes either induced by LPS or poly I:C. RT-PCR showed ATRA inhibited IP-10 expression through decreasing the level of transcription. Furthermore, ATRA suppressed the expression of LPS-stimulated c-Raf, MKK1/2 and ERK expression of THP-1 cells. In conclusion, ATRA suppressed Th2- and Th1-related chemokines expression in THP-1 cells, at least in part via the c-Raf-MKK1/2-ERK/MAPK pathway.

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“…Macrophage-derived chemokine (MDC; CCL22) and thymus-and activation-regulated chemokine (TARC; CCL17) are Th2 chemokines involved in the recruitment of CC chemokine receptor 4-bearing Th2 cells in allergen-induced inflammation [7]. Increased levels of plasma MDC and TARC have been found in children with acute asthma, but their levels decrease after ketotifen treatment [8].…”

mentioning

confidence: 99%

Effects of formoterol and salmeterol on the production of Th1- and Th2-related chemokines by monocytes and bronchial epithelial cells

Yt²,

Ym³

et al. 2008

European Respiratory Journal

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It is unknown whether formoterol and salmeterol, two long-acting b 2 -adrenoreceptor agonists, have regulatory functions in the production of T-helper cell (Th) type 2-and Th1-related chemokines by monocytes and bronchial epithelial cells.In the present study, the effects of formoterol and salmeterol on lipopolysaccharide (LPS)-induced expression of the Th2-related chemokine macrophage-derived chemokine (MDC; CCL22) and the Th1-related chemokine interferon-c-inducible protein (IP)-10 (CXCL10) were investigated in a monocytic cell line, THP-1, and in human primary monocytes. In addition, their effects on the expression of the Th2-related chemokine thymus-and activation-regulated chemokine (TARC; CCL17) were evaluated in an epithelial cell line, BEAS-2B.Formoterol enhanced MDC but suppressed IP-10 production in monocytes induced by LPS. Higher doses of salmeterol were required to enhance LPS-induced MDC expression in THP-1 cells. Formoterol and salmeterol could significantly suppress TARC expression in BEAS-2B cells. These effects could be reversed by a selective b 2 -adrenoreceptor antagonist, ICI-118551. Formoterol-and LPS-induced MDC expression was inhibited by budesonide.Both long-acting b 2 -adrenoreceptor agonists suppressed thymus-and activation-regulated chemokine expression in bronchial epithelial cells mediated via b 2 -adrenoreceptors. Formoterol at physiological concentrations could suppress lipopolysaccharide-induced T-helper cell type 1-related chemokine (interferon-c-inducible protein-10) but enhance T-helper cell type 2-related chemokine (macrophage-derived chemokine) expression in human monocytes. Long-acting b 2 -adrenoreceptor agonists may increase T-helper cell type 2-related chemokine expression in monocytes and T-helper cell type 2 recruitment and, therefore, long-acting b 2 -adrenoreceptor agonist monotherapy may not be an appropriate therapeutic option for asthma.

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Discrepant clinical responses and blood chemokine profiles between two non‐steroidal anti‐inflammatory medications for children with mild persistent asthma

Cited by 20 publications

References 16 publications

A Novel Mechanism for CCR4 in the Regulation of Macrophage Activation in Bleomycin-Induced Pulmonary Fibrosis

A Novel Mechanism for CCR4 in the Regulation of Macrophage Activation in Bleomycin-Induced Pulmonary Fibrosis

Effects of All-Trans Retinoic Acid on Th1- and Th2-Related Chemokines Production in Monocytes

Effects of formoterol and salmeterol on the production of Th1- and Th2-related chemokines by monocytes and bronchial epithelial cells

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