Discrepancy of subjective and objective sleep problems in Alzheimer’s disease and mild cognitive impairment detected by a home-based sleep analysis

Sleep, Mild Cognitive Impairment, and Interventions for Sleep Improvement: An Integrative Review

“…This was contrary to findings of another study, in which there was no difference in REM percentage and REM latency between those with aMCI and healthy controls (Cavuoto et al, 2019). Subjects with AD also had significantly shorter REM sleep (18.4%), as well as a higher proportion of non-REM light sleep compared to healthy controls (25.2%) and subjects with MCI (19.3%), with no difference in REM sleep latency among the three groups (Tadokoro et al, 2020). Regarding KCs, individuals with AD had a lower density of KC compared to healthy counterparts (t = 3.7, p < .01) and to those with MCI (t = 3.42, p < .05).…”

“…The case was similar in a study involving subjects with AD and MCI, whereby subjective and objective sleep measures did not align: subjects with AD reported a significantly better sleep quality (higher PSQI scores), compared to healthy subjects and those with MCI, with no significant differences in reports of daytime sleepiness between the three groups (Tadokoro et al, 2020). However, objective sleep measures showed worse sleep measures in individuals with AD compared to the other two groups (Tadokoro et al, 2020). On the other hand, in another study, self-reported sleep quality was not significantly different between individuals with MCI, AD, and healthy controls.…”

“…Note that, PSG recordings of the same sample in one of the two studies did not significantly correlate with any of the self-reports of sleep provided by MCI subjects (Hita-Yanez et al, 2013). The case was similar in a study involving subjects with AD and MCI, whereby subjective and objective sleep measures did not align: subjects with AD reported a significantly better sleep quality (higher PSQI scores), compared to healthy subjects and those with MCI, with no significant differences in reports of daytime sleepiness between the three groups (Tadokoro et al, 2020). However, objective sleep measures showed worse sleep measures in individuals with AD compared to the other two groups (Tadokoro et al, 2020).…”

“…Findings were contradictory regarding changes in WASO, sleep fragmentation, and sleep efficiency. Also, objective measures within studies did not align with self-reports of participants (Hita-Yanez et al, 2013;Tadokoro et al, 2020). The relationship between sleep and depression was also contradictory.…”

“…Objective versus subjective sleep measures. There was consensus across articles using objective sleep measures such as PSG, sensors, and actigraphy, that total sleep time (TST) did not significantly vary between healthy older adults and those with MCI or AD, which ranged between 6.5 and 8.5 hours among participants from various studies (Cavuoto et al, 2019;Hayes et al, 2014;Hita-Yanez et al, 2012;Sanchez-Espinosa et al, 2014;Tadokoro et al, 2020). However, the findings of one study (Yu et al, 2017) in which researchers measured sleep using the Pittsburgh Sleep Quality Index (PSQI) contradicted this consensus.…”