Discrepancy in IGF-1 and GH response to submaximal exercise in young male subjects

Elj, Naziha El; Elloumi, Mohamed; Zaouali, Monia; Latiri, Imed; Lac, G.; Tabka, Zouhaïr

doi:10.1016/j.scispo.2007.06.002

Cited by 6 publications

(2 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Physiological adaptations to exercise training can be broadly characterized in 2 relevant tissues: skeletal muscle and the vasculature, both of which require specific stimuli to elicit adaptation. During traditional resistance training, the blood-borne physiological biomarkers of skeletal muscle growth (e.g., insulin-like growth factor-1 [IGF-1], insulinlike growth factor binding proteins [IGFBP], and human growth hormone [GH]) are influenced by the modality, duration, and intensity of the exercise session (9,31). Similarly, physiological biomarkers of angiogenesis (e.g., vascular endothelial growth factor [VEGF]) are influenced by rate of blood flow and metabolic demands of the exercise bout (14,15,17,30).…”

Section: Introductionmentioning

confidence: 99%

Acute Effect of Popular High-Intensity Functional Training Exercise on Physiologic Markers of Growth

Kliszczewicz

Markert

Bechke

et al. 2021

Journal of Strength and Conditioning Research

View full text Add to dashboard Cite

Kliszczewicz, B, Markert, CD, Bechke, E, Williamson, C, Clemons, KN, Snarr, RL, and McKenzie, MJ. Acute effect of popular high-intensity functional training exercise on physiologic markers of growth. J Strength Cond Res 35(6): 1677–1684, 2021—Constantly evolving, high-intensity functional training (HIFT) exercise consists of various modalities, orders, weights, and repetition schemes. High-intensity functional training has gained popularity among the general population, but lacks empirical evidence regarding acute adaptive responses. The purpose of this study was to describe the acute effects of 2 representative bouts of HIFT on physiologic markers of growth. For convenience, the bouts are designated “short” (<5 minutes) and “long” (∼15 minutes), although duration was not the only difference between bouts. Ten apparently healthy men (28.1 ± 5 years) performed 2 HIFT bouts in a randomized crossover design. Blood was collected at 5 time points (Pre, Post, 1, 3, and 6 hours) to examine growth hormone (GH), insulin-like growth factor (IGF-1), insulin-like growth factor binding proteins 1 and 2 (IGFBP-1 and IGFBP-2), and vascular endothelial growth factor (VEGF). Blood lactate concentration ([La]) was analyzed at the Pre and Post time points. A repeated-measures analysis of variance (ANOVA) revealed no trial differences among the markers (IGF-1, IGFBP-1, IGFBP-2, and VEGF) except GH at Post, where the long bout produced a greater effect (p = 0.005). Mean GH levels (pg·ml−1) in the short bout increased from 68.4 to 106.5, and in the long bout, mean GH levels increased from 38.5 to 286.4. The repeated-measures ANOVA revealed a main time effect in GH (p = 0.037), while a post hoc t-test demonstrated elevated GH at 1 hour (p = 0.018) when compared with Pre. No time-dependent change (p > 0.05) was observed in IGF-1, IGFBP-1, IGFBP-2, or VEGF. Mean blood [lactate] increased more than tenfold in both bouts. The findings of this descriptive study suggest that, other than GH, there are no acute differences in markers of skeletal muscle or vascular growth between these 2 specific HIFT bouts.

show abstract

Section: Introductionmentioning

confidence: 99%

Acute Effect of Popular High-Intensity Functional Training Exercise on Physiologic Markers of Growth

Kliszczewicz

Markert

Bechke

et al. 2021

Journal of Strength and Conditioning Research

View full text Add to dashboard Cite

show abstract

“…Adhering to the principle of overload during resistance training is known to elevate the levels of anabolic hormones such as testosterone and insulin-like growth factor, as well as enhance neuromuscular function [ 10 , 11 , 12 ]. The surge in anabolic hormones is typically influenced by various factors of resistance training, including the intensity of the load, the training volume (number of sets and repetitions per set), rest duration between sets, and the total muscle groups engaged [ 11 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of ADORA2A Gene Polymorphism and Acute Caffeine Supplementation on Hormonal Response to Resistance Exercise: A Double-Blind, Crossover, Placebo-Controlled Study

Rahimi,

Semenova,

John

et al. 2024

Nutrients

View full text Add to dashboard Cite

Previous studies have reported that TT genotype carriers of the adenosine A2a receptor (ADORA2A) gene rs5751876 polymorphism have better ergogenic and anti-inflammatory responses to caffeine intake compared to C allele carriers. The aim of the present study was twofold: (1) to investigate the association of the ADORA2A rs5751876 polymorphism with acute caffeine supplementation on hormonal (growth hormone and testosterone) response to resistance exercise (RE); (2) to examine the relationship between the rs5751876 polymorphism and the resting levels of growth hormone and testosterone in athletes who are light caffeine consumers. A double-blind, crossover, placebo-controlled study involving 30 resistance-trained men (age 21.7 ± 4.1) was conducted to assess the impact of caffeine supplementation on serum growth hormone (GH) and testosterone (TS) levels before, immediately after, and 15 min post-RE. One hour before engaging in resistance exercise, subjects were randomly administered 6 mg of caffeine per kg of body mass or a placebo (maltodextrin). After a 7-day washout period, the same protocol was repeated. Resting testosterone and growth hormone levels were examined in the sera of 94 elite athletes (31 females, age 21.4 ± 2.8; 63 males, age 22.9 ± 3.8). Caffeine consumption led to significantly greater increases in GH and TS in men with the TT genotype compared to C allele carriers. Furthermore, in the group of athletes, carriers of the TT genotype had significantly higher testosterone (p = 0.0125) and growth hormone (p = 0.0365) levels compared to C allele carriers. In conclusion, the ADORA2A gene rs5751876 polymorphism may modify the effect of caffeine intake on the hormonal response to exercise.

show abstract

Time course responses of serum GH, insulin, IGF-1, IGFBP1, and IGFBP3 concentrations after heavy resistance exercise in trained and untrained men

et al. 2011

View full text Add to dashboard Cite

To investigate the effect of heavy resistance exercise on IGF-1 system, 19 healthy trained men and 15 healthy untrained men volunteered to participate in this study. The subjects were randomly divided into experimental and control groups. Subjects of experimental groups were forced to perform a heavy resistance exercise with the intensity of 70-80% of 1RM in selected movements. The blood samples were taken from all subjects four times; before (T1), immediately after (T2), 5 (T3), and 8 (T4) hours after exercise. Analysis of data showed that a session of heavy resistance exercise induced significant increase in GH at T2 (P < 0.05) and a significant decrease in insulin at T4 (P < 0.05) and a significant decrease in IGFBP3 at T4 (P < 0.05) in trained group. In untrained group, no significant change in any of the variables was observed. However, the procedure of response in variables was almost similar in two experimental groups. Although, the exercise did not appreciably affect IGF-1 levels, it decreased in all groups at length of time after exercise. In addition, the exercise did not have any notable effect on IGFBP1 levels over time. In conclusion, the findings of this study indicate that the intense resistance exercise can lead to changes in blood concentrations of IGF-1 system components which are observable in blood circulation over time and the amounts of changes depend on subjects' fitness levels and exercise variables.

show abstract

Discrepancy in IGF-1 and GH response to submaximal exercise in young male subjects

Cited by 6 publications

References 28 publications

Acute Effect of Popular High-Intensity Functional Training Exercise on Physiologic Markers of Growth

Acute Effect of Popular High-Intensity Functional Training Exercise on Physiologic Markers of Growth

Effect of ADORA2A Gene Polymorphism and Acute Caffeine Supplementation on Hormonal Response to Resistance Exercise: A Double-Blind, Crossover, Placebo-Controlled Study

Time course responses of serum GH, insulin, IGF-1, IGFBP1, and IGFBP3 concentrations after heavy resistance exercise in trained and untrained men

Contact Info

Product

Resources

About