Discrepancy Between Initial High Expression of Interest in Clinical Cancer Genetic Testing and Actual Low Uptake in an Asian Population

Abstract

A significant discrepancy exists between an initial high interest in testing and actual low uptake. Health programs that address cost issues and education to correct misperceptions may improve genetic information utilization.

Impact of subsidies on cancer genetic testing uptake in Singapore

“…Unfortunately, our FDR predictive testing rate of 6% in our service is disappointing, far below the reported ratios in other established services 23. The low uptake of predictive testing is contrary to survey findings of high interest in predictive screening of unaffected family members in Singapore 3 7 25. Patients who declined predictive testing in other studies have cited fear of emotional burden and stress associated with genetic information on themselves as reasons for not availing themselves to genetic testing 3 7 26.…”

“…The low uptake of predictive testing is contrary to survey findings of high interest in predictive screening of unaffected family members in Singapore 3 7 25. Patients who declined predictive testing in other studies have cited fear of emotional burden and stress associated with genetic information on themselves as reasons for not availing themselves to genetic testing 3 7 26. This is an area in critical need for further research so as to best understand how we can improve FDR testing rates to optimise health impact.…”

Factors influencing the decision to share cancer genetic results among family members: An in‐depth interview study of women in an Asian setting

“…We designed an open‐ended, semistructured interview guide to explore key areas, based on our previous clinical experiences and a literature review . The draft interview guide was pilot‐tested on colleagues and 1 volunteer patient not participating in the study.…”

“…We designed an open-ended, semistructured interview guide to explore key areas, based on our previous clinical experiences and a literature review. [13][14][15] The draft interview guide was pilot-tested on colleagues and 1 volunteer patient not participating in the study. Following the pilot, the research team consisting of clinicians, health services researchers, sociologists, and an educator added expertise and knowledge of local health literacy and education among patients to refine the final question guide and probes ( Table S1).…”

Post-exercise branched chain amino acid supplementation does not affect recovery markers following three consecutive high intensity resistance training bouts compared to carbohydrate supplementation

“…In this regard, Malm et al [ 37 ] reported that circulating monocyte numbers and percentages robustly increase up to 7 days following a muscle-damaging eccentric protocol; an effect which paralleled the appearance of macrophages in skeletal muscle tissue. While we are unaware of studies that have examined the ability of BCAA supplementation to reduce post-exercise monocyte proliferation and skeletal muscle macrophage infiltration, it has been recently posited that BCAAs can be transaminated to glutamate in order to increase glutamine synthesis which, in turn, can be consumed by macrophages as a fuel source to propagate inflammation [ 38 ]. Notwithstanding, our findings that BCAAs are able to prevent the elevation in monocyte percentages over three days of rigorous weightlifting may suggest that BCAAs may possess an anti-inflammatory properties and should be further researched.…”